J.Z. is supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-2038238. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. A.Z. and J.H. are supported by NIH R01 AI163483 and R01 EB030134. A.Z. is further supported by NIH U01 CA265719 and receives institutional support from NIH P30 DK120515, P30 DK063491, P30 CA014195 and UL1 TR001442.