Acosta SA, Tajiri N, de la Pena I, Bastawrous M, Sanberg PR, Kaneko Y et al (2015) Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson’s disease. J Cell Physiol 230:1024–1032. https://doi.org/10.1002/jcp.24830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aguilar-Pineda JA, Vera-Lopez KJ, Shrivastava P, Chávez-Fumagalli MA, Nieto-Montesinos R, Alvarez-Fernandez KL, Goyzueta Mamani LD, Davila Del-Carpio G, Gomez-Valdez B, Miller CL, Malhotra R, Lindsay ME, Lino Cardenas CL (2021) Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. iScience 24:102993. https://doi.org/10.1016/j.isci.2021.102993

Amin J, Holmes C, Dorey RB, Tommasino E, Casal YR, Williams DM et al (2020) Neuroinflammation in dementia with Lewy bodies: a human post-mortem study. Transl Psychiatry 10:267

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armulik A, Genové G, Mäe M, Nisancioglu MH, Wallgard E, Niaudet C et al (2010) Pericytes regulate the blood-brain barrier. Nature 468:557–561. https://doi.org/10.1038/nature09522

Article  CAS  PubMed  Google Scholar 

Ashok A, Rai NK, Raza W, Pandey R, Bandyopadhyay S (2016) Chronic cerebral hypoperfusion-induced impairment of Aβ clearance requires HB-EGF-dependent sequential activation of HIF1α and MMP9. Neurobiol Dis 95:179–193. https://doi.org/10.1016/j.nbd.2016.07.013

Article  CAS  PubMed  Google Scholar 

Back DB, Choi B-R, Han J-S, Kwon KJ, Choi D-H, Shin CY et al (2020) Characterization of tauopathy in a rat model of post-stroke dementia combining acute infarct and chronic cerebral hypoperfusion. Int J Mol Sci. https://doi.org/10.3390/ijms21186929

Article  PubMed  PubMed Central  Google Scholar 

Bellomo M, Adamo EB, Deodato B, Catania MA, Mannucci C, Marini H et al (2003) Enhancement of expression of vascular endothelial growth factor after adeno-associated virus gene transfer is associated with improvement of brain ischemia injury in the gerbil. Pharmacol Res 48:309–317. https://doi.org/10.1016/S1043-6618(03)00128-2

Article  CAS  PubMed  Google Scholar 

Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG (2004) Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 165:1643–1652

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellucci A, Bugiani O, Ghetti B, Spillantini MG (2011) Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation. Neurodegener Dis 8:221–229. https://doi.org/10.1159/000322228

Article  PubMed  PubMed Central  Google Scholar 

Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T et al (2018) Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease. Proc Natl Acad Sci 115:E1289–E1298. https://doi.org/10.1073/pnas.1710329115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin Y-C et al (2015) Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta Neuropathol Commun 3:8. https://doi.org/10.1186/s40478-015-0186-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blanchard JW, Bula M, Davila-Velderrain J, Akay LA, Zhu L, Frank A et al (2020) Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes. Nat Med 26:952–963. https://doi.org/10.1038/s41591-020-0886-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogale TA, Faustini G, Longhena F, Mitola S, Pizzi M, Bellucci A (2021) Alpha-synuclein in the regulation of brain endothelial and perivascular cells: gaps and future perspectives. Front Immunol 12:611761. https://doi.org/10.3389/fimmu.2021.611761

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brandenburg S, Müller A, Turkowski K, Radev YT, Rot S, Schmidt C et al (2016) Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol 131:365–378

Article  CAS  PubMed  Google Scholar 

Brelstaff J, Tolkovsky AM, Ghetti B, Goedert M, Spillantini MG (2018) Living neurons with tau filaments aberrantly expose phosphatidylserine and are phagocytosed by microglia. Cell Rep 24:1939–1948

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brelstaff JH, Mason M, Katsinelos T, McEwan WA, Ghetti B, Tolkovsky AM, Spillantini MG (2021) Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Sci Adv 7:eabg4980

Brett BL, Gardner RC, Godbout J, Dams-O’Connor K, Keene CD (2022) Traumatic brain injury and risk of neurodegenerative disorder. Biol Psychiatry 91:498–507. https://doi.org/10.1016/j.biopsych.2021.05.025

Article  CAS  PubMed  Google Scholar 

Brown EG, Goldman SM (2020) Traumatic brain injury and α-synuclein. Neurology 94:335–336. https://doi.org/10.1212/WNL.0000000000008991

Article  PubMed  Google Scholar 

Brown LS, Foster CG, Courtney J-M, King NE, Howells DW, Sutherland BA (2019) Pericytes and neurovascular function in the healthy and diseased brain. Front Cell Neurosci 13:282. https://doi.org/10.3389/fncel.2019.00282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cardozo CF, Vera A, Quintana-Peña V, Arango-Davila CA, Rengifo J (2023) Regulation of Tau protein phosphorylation by glucosamine-induced O-GlcNAcylation as a neuroprotective mechanism in a brain ischemia-reperfusion model. Int J Neurosci 133:194–200. https://doi.org/10.1080/00207454.2021.1901695

Article  CAS  PubMed  Google Scholar 

Carlson SW, Yan HQ, Li Y, Henchir J, Ma X, Young MS et al (2021) Differential regional responses in soluble monomeric alpha synuclein abundance following traumatic brain injury. Mol Neurobiol 58:362–374. https://doi.org/10.1007/s12035-020-02123-w

Article  PubMed  Google Scholar 

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P et al (2017) Cerebral microvascular accumulation of tau oligomers in Alzheimer’s disease and related tauopathies. Aging Dis 8:257

Article  PubMed  PubMed Central  Google Scholar 

Collins-Praino LE, Corrigan F (2017) Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury? Brain Behav Immun 60:369–382. https://doi.org/10.1016/j.bbi.2016.09.027

Article  CAS  PubMed  Google Scholar 

Cruz Hernández JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M et al (2019) Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models. Nat Neurosci 22:413–420. https://doi.org/10.1038/s41593-018-0329-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cruz-Haces M, Tang J, Acosta G, Fernandez J, Shi R (2017) Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases. Transl Neurodegen 6:20. https://doi.org/10.1186/s40035-017-0088-2

Article  CAS  Google Scholar 

Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468:562–566. https://doi.org/10.1038/nature09513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denes A, Hansen CE, Oezorhan U, Figuerola S, de Vries HE, Sorokin L, Planas AM, Engelhardt B, Schwaninger M (2023) Endothelial cells and macrophages as allies in the brain. Acta Neuropathol

De Reuck JL, Deramecourt V, Cordonnier C, Leys D, Pasquier F, Maurage CA (2012) Cerebrovascular lesions in patients with frontotemporal lobar degeneration: a neuropathological study. Neurodegener Dis 9:170–175. https://doi.org/10.1159/000335447

Article  PubMed  Google Scholar 

DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RSB et al (2007) Association of increased cortical soluble Aβ42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol 64:541. https://doi.org/10.1001/archneur.64.4.541

Article  PubMed  Google Scholar 

Delic V, Beck KD, Pang KCH, Citron BA (2020) Biological links between traumatic brain injury and Parkinson’s disease. Acta Neuropathol Commun 8:45. https://doi.org/10.1186/s40478-020-00924-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dieriks BV, Park TI-H, Fourie C, Faull RLM, Dragunow M, Curtis MA (2017) α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients. Sci Rep 7:42984. https://doi.org/10.1038/srep42984

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dieriks BV, Highet B, Alik A, Bellande T, Stevenson TJ, Low V et al (2022) Human pericytes degrade diverse α-synuclein aggregates. PLoS ONE 17:e0277658. https://doi.org/10.1371/journal.pone.0277658

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dietrich HH, Xiang C, Han BH, Zipfel GJ, Holtzman DM (2010) Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells. Mol Neurodegener 5:15. https://doi.org/10.1186/1750-1326-5-15

Article  CAS