Narunsky-Haziza, L. et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 185, 3789–3806.e17 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dohlman, A. B. et al. A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell 185, 3807–3822.e12 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, N. N. et al. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nat. Microbiol. 7, 238–250 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riquelme, E. et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell 178, 795–806.e12 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee, S. et al. Prognostic correlations with the microbiome of breast cancer subtypes. Cell Death Dis. 12, 831 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Aykut, B. et al. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature 574, 264–267 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nejman, D. et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368, 973–980 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu, Q. et al. AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal. Transduct. Target. Ther. 6, 299 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vadovics, M. et al. Candida albicans enhances the progression of oral squamous cell carcinoma in vitro and in vivo. mBio 13, e0314421 (2021).

Article  PubMed  Google Scholar 

Alam, A. et al. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell 40, 153–167.e11 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, X. V. et al. Immune regulation by fungal strain diversity in inflammatory bowel disease. Nature 603, 672–678 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon, T. J. et al. Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Int. Immunopharmacol. 8, 36–42 (2008).

Article  CAS  PubMed  Google Scholar 

Gao, R. et al. Dysbiosis signature of mycobiota in colon polyp and colorectal cancer. Eur. J. Clin. Microbiol. Infect. Dis. 36, 2457–2468 (2017).

Article  CAS  PubMed  Google Scholar 

Richard, M. L. et al. Mucosa-associated microbiota dysbiosis in colitis associated cancer. Gut Microbes 9, 131–142 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Zhu, Y. et al. Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22. EMBO J. 40, e105320 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong, M. et al. Candida albicans disorder is associated with gastric carcinogenesis. Theranostics 11, 4945–4956 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, L. et al. Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma. J. Transl. Med. 21, 126 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shiao, S. L. et al. Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy. Cancer Cell 39, 1202–1213.e6 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riquelme, E. & McAllister, F. Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer. Cancer Cell 39, 1173–1175 (2021).

Article  CAS  PubMed  Google Scholar 

Gihawi, A. et al. Major data analysis errors invalidate cancer microbiome findings. mBio 14, e0160723 (2023).

Article  PubMed  Google Scholar 

Sepich-Poore G. D. et al. Reply to: caution regarding the specificities of pan-cancer microbial structure. Preprint at bioRxiv https://doi.org/10.1101/2023.02.10.528049 (2023).

Lapiere, A. & Richard, M. L. Bacterial-fungal metabolic interactions within the microbiota and their potential relevance in human health and disease: a short review. Gut Microbes 14, 2105610 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Nogueira, F., Sharghi, S., Kuchler, K. & Lion, T. Pathogenetic impact of bacterial-fungal interactions. Microorganisms 7, 459 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santus, W., Devlin, J. R. & Behnsen, J. Crossing kingdoms: how the mycobiota and fungal-bacterial interactions impact host health and disease. Infect. Immun. 89, e00648-20 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Shekarian, T. et al. Pattern recognition receptors: immune targets to enhance cancer immunotherapy. Ann. Oncol. 28, 1756–1766 (2017).

Article  CAS  PubMed  Google Scholar 

Zhai, B. et al. High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. Nat. Med. 26, 59–64 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kusakabe, T. et al. Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19. Nat. Immunol. 24, 1879–1889 (2023).

Article  CAS  PubMed  Google Scholar 

Fan, D. et al. Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Nat. Med. 21, 808–814 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon, S. Y., Park, S. J. & Park, Y. J. The anticancer properties of cordycepin and their underlying mechanisms. Int. J. Mol. Sci. 19, 3027 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Fletcher, A. A., Kelly, M. S., Eckhoff, A. M. & Allen, P. J. Revisiting the intrinsic mycobiome in pancreatic cancer. Nature 620, E1–E6 (2023).

Article  CAS  PubMed  Google Scholar