aSchool of Human Development and Health, Faculty of Medicine, University of Southampton

bNational Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, UK

cDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Correspondence to Dr Eleonora Scorletti, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Tel: +1 215 305 2275; e-mail: [email protected]