Sepsis in elderly patients: the role of neutrophils in pathophysiology and therapy

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delano MJ, Ward PA (2016) The immune system’s role in sepsis progression, resolution, and long-term outcome. Immunol Rev 274(1):330–353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camici GG, Liberale L (2017) Aging: the next cardiovascular disease? Eur Heart J 38(21):1621–1623

Article  CAS  PubMed  Google Scholar 

Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F et al (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128(1):92–105

Article  CAS  PubMed  Google Scholar 

Liberale L, Montecucco F, Tardif JC, Libby P, Camici GG (2020) Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J 41(31):2974–2982

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberale L, Badimon L, Montecucco F, Luscher TF, Libby P, Camici GG (2022) Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol 79(8):837–847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pawelec G (2018) Age and immunity: What is “immunosenescence”? Exp Gerontol 105:4–9

Article  CAS  PubMed  Google Scholar 

Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH et al (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306(23):2594–2605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Otto GP, Sossdorf M, Claus RA, Rodel J, Menge K, Reinhart K et al (2011) The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care 15(4):R183

Article  PubMed  PubMed Central  Google Scholar 

Jones TK, Fuchs BD, Small DS, Halpern SD, Hanish A, Umscheid CA et al (2015) Post-acute care use and hospital readmission after sepsis. Ann Am Thorac Soc 12(6):904–913

Article  PubMed  PubMed Central  Google Scholar 

Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13(12):862–874

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaw AC, Goldstein DR, Montgomery RR (2013) Age-dependent dysregulation of innate immunity. Nat Rev Immunol 13(12):875–887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denning NL, Aziz M, Gurien SD, Wang P (2019) DAMPs and NETs in Sepsis. Front Immunol 10:2536

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chousterman BG, Swirski FK, Weber GF (2017) Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol 39(5):517–528

Article  CAS  PubMed  Google Scholar 

Liu D, Huang SY, Sun JH, Zhang HC, Cai QL, Gao C et al (2022) Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Mil Med Res 9(1):56

CAS  PubMed  PubMed Central  Google Scholar 

Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F (2010) Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol 11:30

Article  PubMed  PubMed Central  Google Scholar 

Palsson-McDermott EM, O’Neill LA (2013) The Warburg effect then and now: from cancer to inflammatory diseases. BioEssays 35(11):965–973

Article  CAS  PubMed  Google Scholar 

Drew W, Wilson DV, Sapey E (2018) Inflammation and neutrophil immunosenescence in health and disease: targeted treatments to improve clinical outcomes in the elderly. Exp Gerontol 105:70–77

Article  PubMed  Google Scholar 

Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D et al (2019) Reactive Oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev 2019:5080843

Article  PubMed  PubMed Central  Google Scholar 

Cao C, Yu M, Chai Y (2019) Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell Death Dis 10(10):782

Article  PubMed  PubMed Central  Google Scholar 

Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16(7):407–420

Article  CAS  PubMed  Google Scholar 

Chen KW, Gross CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ et al (2014) The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge. Cell Rep 8(2):570–582

Article  CAS  PubMed  Google Scholar 

Lara PC, Macias-Verde D, Burgos-Burgos J (2020) Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients. Aging Dis 11(4):756–762

Article  PubMed  PubMed Central  Google Scholar 

Youm YH, Grant RW, McCabe LR, Albarado DC, Nguyen KY, Ravussin A et al (2013) Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 18(4):519–532

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin L, Batra S, Jeyaseelan S (2017) Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis. J Immunol 198(3):1253–1262

Article  CAS  PubMed  Google Scholar 

Luo YP, Jiang L, Kang K, Fei DS, Meng XL, Nan CC et al (2014) Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1. Int Immunopharmacol 20(1):24–32

Article  CAS  PubMed  Google Scholar 

Wu Y, Ren J, Zhou B, Ding C, Chen J, Wang G et al (2015) Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model. Clin Exp Immunol 179(2):277–293

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hellebrekers P, Vrisekoop N, Koenderman L. Neutrophil phenotypes in health and disease. Eur J Clin Invest. 2018;48 Suppl 2(Suppl Suppl 2):e12943.

Christoffersson G, Vagesjo E, Vandooren J, Liden M, Massena S, Reinert RB et al (2012) VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood 120(23):4653–4662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW et al (2012) A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest 122(1):327–336

Article  CAS  PubMed  Google Scholar 

Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A et al (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J Biol Chem 286(9):7070–7081

Article  CAS  PubMed  Google Scholar 

Alder MN, Opoka AM, Lahni P, Hildeman DA, Wong HR (2017) Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock. Crit Care Med 45(4):e426–e432

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eash KJ, Greenbaum AM, Gopalan PK, Link DC (2010) CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest 120(7):2423–2431

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin C, Burdon PC, Bridger G, Gutierrez-Ramos JC, Williams TJ, Rankin SM (2003) Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity 19(4):583–593

Article  CAS  PubMed  Google Scholar 

Chatta GS, Andrews RG, Rodger E, Schrag M, Hammond WP, Dale DC (1993) Hematopoietic progenitors and aging: alterations in granulocytic precursors and responsiveness to recombinant human G-CSF, GM-CSF, and IL-3. J Gerontol 48(5):M207–M212

Article  CAS  PubMed  Google Scholar 

Brubaker AL, Rendon JL, Ramirez L, Choudhry MA, Kovacs EJ (2013) Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol 190(4):1746–1757

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