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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v62i02.4286Title: Antioxidant efficiency of Prunus laurocerasus L. fruit extract on doxorubicin induced hepatic and renal damageAuthors: Cirrik, Selma
Hacioglu, Gulay
Cokeli, Emel Kabartan
Peker, Emine Gulceri GulecKeywords: Albumin;Cherry laurel;Creatinine;Glomerular filtration rate (GFR);Kidney injury molecule-1 (Kim-1);Liver;Neutrophil gelatinase-associated lipocalin (NGAL);Oxidative stress;Reactive oxygen species (ROS);Tissue damageIssue Date: Feb-2024Publisher: NIScPR-CSIR, IndiaAbstract: In Turkish traditional medicine, the leaves, fruit and seeds of Prunus laurocerasus L., commonly called Cherry laurel, are used to treat various diseases such as cancer, diabetes, influenza, tonsillitis and scalp dandruff. The medicinal value of this plant can be attributed to its rich phenolic content and high antioxidant capacity. In this study, we investigated the efficacy of P. laurocerasus (PL) fruit extract in reducing the hepatorenal side effects of doxorubicin (DOX). Sprague- Dawley rats were divided into 4 groups as Control, DOX, PL500+DOX and PL1000+DOX (n=8). PL-extracts were given perorally for two weeks (500 or 1000 mg.kg-1.day-1). After 48–h of DOX injection (15 mg/kg, i.p.), the animals were sacrificed. Compared to control, in DOX group, we observed lower levels of serum albumin, higher alanine transaminase (ALT), aspartate transaminase (AST) and creatinine levels (P Page(s): 103-111ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.62(02) [Feb 2024]

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