Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004;164:1275–84. https://doi.org/10.1001/archinte.164.12.1275.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM. Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis. Nat Rev Rheumatol. 2021;17:333–48. https://doi.org/10.1038/s41584-021-00605-2.
Article CAS PubMed PubMed Central Google Scholar
Ho S-M, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung Y-K. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 2012;53:289–305. https://doi.org/10.1093/ilar.53.3-4.289.
Article CAS PubMed PubMed Central Google Scholar
Cole MB, Quach H, Quach D, Baker A, Taylor KE, Barcellos LF, Criswell LA. Epigenetic signatures of salivary gland inflammation in Sjögren’s syndrome. Arthritis Rheumatol. 2016;68:2936–44. https://doi.org/10.1002/art.39792.
Article CAS PubMed PubMed Central Google Scholar
Chi C, Taylor KE, Quach H, Quach D, Criswell LA, Barcellos LF. Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren’s syndrome. PLoS ONE. 2021;16:e0248429. https://doi.org/10.1371/journal.pone.0248429.
Article CAS PubMed PubMed Central Google Scholar
Tian Y, Morris TJ, Webster AP, Yang Z, Beck S, Feber A, Teschendorff AE. ChAMP: updated methylation analysis pipeline for Illumina BeadChips. Bioinformatics. 2017;33:3982–4. https://doi.org/10.1093/bioinformatics/btx513.
Article CAS PubMed PubMed Central Google Scholar
Peters TJ, Buckley MJ, Statham AL, Pidsley R, Samaras K, Lord RV, Clark SJ, Molloy PL. De novo identification of differentially methylated regions in the human genome. Epigenetics Chromatin. 2015;8:6. https://doi.org/10.1186/1756-8935-8-6.
Article CAS PubMed PubMed Central Google Scholar
Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, Fu X, Liu S, Bo X, Yu G. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2:100141. https://doi.org/10.1016/j.xinn.2021.100141.
Article CAS PubMed PubMed Central Google Scholar
Zheng SC, Breeze CE, Beck S, Teschendorff AE. Identification of differentially methylated cell types in epigenome-wide association studies. Nat Methods. 2018;15:1059–66. https://doi.org/10.1038/s41592-018-0213-x.
Article CAS PubMed PubMed Central Google Scholar
Koestler DC, Jones MJ, Usset J, Christensen BC, Butler RA, Kobor MS, Wiencke JK, Kelsey KT. Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC Bioinforma. 2016;17:120. https://doi.org/10.1186/s12859-016-0943-7.
Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30:1363–9. https://doi.org/10.1093/bioinformatics/btu049.
Article CAS PubMed PubMed Central Google Scholar
Chakravarthy A, Furness A, Joshi K, Ghorani E, Ford K, Ward MJ, King EV, Lechner M, Marafioti T, Quezada SA, Thomas GJ, Feber A, Fenton TR. Pan-cancer deconvolution of tumour composition using DNA methylation. Nat Commun. 2018;9:3220. https://doi.org/10.1038/s41467-018-05570-1.
Article CAS PubMed PubMed Central Google Scholar
Varin M-M, Guerrier T, Devauchelle-Pensec V, Jamin C, Youinou P, Pers J-O. In Sjögren’s syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation. Autoimmun Rev. 2012;11:252–8. https://doi.org/10.1016/j.autrev.2011.10.005.
Article CAS PubMed Google Scholar
Li X, Li X, Qian L, Wang G, Zhang H, Wang X, Chen K, Zhai Z, Li Q, Wang Y, Harris DCH. T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren’s syndrome. J Rheumatol. 2007;34:2438–45.
Christodoulou MI, Kapsogeorgou EK, Moutsopoulos NM, Moutsopoulos HM. Foxp3+ T-regulatory cells in Sjogren’s syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am J Pathol. 2008;173:1389–96. https://doi.org/10.2353/ajpath.2008.080246.
Article PubMed PubMed Central Google Scholar
Greenwell-Wild T, Moutsopoulos NM, Gliozzi M, Kapsogeorgou E, Rangel Z, Munson PJ, Moutsopoulos HM, Wahl SM. Chitinases in the salivary glands and circulation of patients with Sjögren’s syndrome: macrophage harbingers of disease severity. Arthritis Rheum. 2011;63:3103–15. https://doi.org/10.1002/art.30465.
Article CAS PubMed PubMed Central Google Scholar
Zhou D, McNamara NA. Macrophages: important players in primary Sjögren’s syndrome? Expert Rev Clin Immunol. 2014;10:513–20. https://doi.org/10.1586/1744666X.2014.900441.
Article CAS PubMed Google Scholar
Stergiou IE, Kapsogeorgou EE, Tzioufas AG, Voulgarelis M, Goules AV. Clinical phenotype and mechanisms of leukopenia/neutropenia in patients with primary Sjögren’s syndrome. Mediterr J Rheumatol. 2022;33:99–101. https://doi.org/10.31138/mjr.33.1.99.
Peng Y, Wu X, Zhang S, Deng C, Zhao L, Wang M, Wu Q, Yang H, Zhou J, Peng L, Luo X, Chen Y, Wang A, Xiao Q, Zhang W, Zhao Y, Zeng X, Fei Y. The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren’s syndrome. Arthritis Res Ther. 2022;24:170. https://doi.org/10.1186/s13075-022-02860-4.
Article CAS PubMed PubMed Central Google Scholar
Fujihara T, Fujita H, Tsubota K, Saito K, Tsuzaka K, Abe T, Takeuchi T. Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjögren’s syndrome. J Immunol. 1999;163:2226–35.
Article CAS PubMed Google Scholar
Kaneko N, Chen H, Perugino CA, Maehara T, Munemura R, Yokomizo S, Sameshima J, Diefenbach TJ, Premo KR, Chinju A, Miyahara Y, Sakamoto M, Moriyama M, Stone JH, Nakamura S, Pillai S. Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome. Sci Rep. 2022;12:15427. https://doi.org/10.1038/s41598-022-19397-w.
Article CAS PubMed PubMed Central Google Scholar
Gao C-Y, Yao Y, Li L, Yang S-H, Chu H, Tsuneyama K, Li X-M, Gershwin ME, Lian Z-X. Tissue-resident memory CD8+ T cells acting as mediators of salivary gland damage in a murine model of Sjögren’s syndrome. Arthritis Rheumatol. 2019;71:121–32. https://doi.org/10.1002/art.40676.
Article CAS PubMed Google Scholar
Barr JY, Wang X, Meyerholz DK, Lieberman SM. CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjögren syndrome. Immunol Cell Biol. 2017;95:684–94. https://doi.org/10.1038/icb.2017.38.
Article CAS PubMed PubMed Central Google Scholar
Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH, Pillai SS. Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Ann Rheum Dis. 2017;76:377–85. https://doi.org/10.1136/annrheumdis-2016-209139.
Article CAS PubMed Google Scholar
Wang Q, Che N, Lu C, Sun X, Wang Y, Wang Q, Tan W, Zhou L, Zhang X, Xu D, Gu L, Zhang M. Correlation of peripheral CD4+GranzB+CTLs with disease severity in patients with primary Sjögren’s syndrome. Arthritis Res Ther. 2021;23:257. https://doi.org/10.1186/s13075-021-02632-6.
Article CAS PubMed PubMed Central Google Scholar
Xanthou G, Tapinos NI, Polihronis M, Nezis IP, Margaritis LH, Moutsopoulos HM. CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjögren’s syndrome. Clin Exp Immunol. 1999;118:154–63. https://doi.org/10.1046/j.1365-2249.1999.01037.x.
Article CAS PubMed PubMed Central Google Scholar
Du Y, Li J, Wu J, Zeng F, He C. Exploration of the pathogenesis of Sjögren’s syndrome via DNA methylation and transcriptome analyses. Clin Rheumatol. 2022;41:2765–77. https://doi.org/10.1007/s10067-022-06200-4.
Benchabane S, Slimani-Kaddouri A, Acheli D, Bendimerad-Iratene T, Mesbah R, Touil-Boukoffa C. Association between increased Bcl-2, Fas and FasL levels and inflammation extent in labial salivary glands during primary Sjögren’s syndrome. Endocr Metab Immune Disord Drug Targets. 2022;22:328–38. https://doi.org/10.2174/1871530321666210809155147.
Article CAS PubMed Google Scholar
Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya J-M, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta M-L, Engelke F, Forsblad-d’Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, Shiboski CH, Wahren-Herlenius M, Ng W-F, Sivils KL, Adrianto I, Nordmark G, Lessard CJ. Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells. Nat Commun. 2022;13:4287. https://doi.org/10.1038/s41467-022-30773-y.
Altorok N, Coit P, Hughes T, Koelsch KA, Stone DU, Rasmussen A, Radfar L, Scofield RH, Sivils KL, Farris AD, Sawalha AH. Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren’s syndrome. Arthritis Rheumatol. 2014;66:731–9. https://doi.org/10.1002/art.38264.
Article CAS PubMed PubMed Central Google Scholar
Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R, Tappuni AR, Pitzalis C, Bombardieri M. Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren’s syndrome. Arthritis Rheumatol. 2014;66:2545–57. https://doi.org/10.1002/art.38726.
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