Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements

World Health Organization. Noncommunicable diseases. 2022. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases.

Han JC, Lawlor DA, Kimm SY. Childhood obesity. Lancet. 2010;375:1737–48.

PubMed  PubMed Central  Google Scholar 

Plourde G. Preventing and managing pediatric obesity: recommendations for family physicians. Can Fam Physician. 2006;52:322–8.

PubMed  PubMed Central  Google Scholar 

Bahreynian M, Qorbani M, Khaniabadi BM, Motlagh ME, Safari O, Asayesh H, et al. Association between obesity and parental weight status in children and adolescents. J Clin Res Pediatr Endocrinol. 2017;9:111–7.

PubMed  PubMed Central  Google Scholar 

Fuemmeler BF, Lovelady CA, Zucker NL, Østbye T. Parental obesity moderates the relationship between childhood appetitive traits and weight. Obesity. 2013;21:815–23.

PubMed  Google Scholar 

Lee JS, Jin MH, Lee HJ. Global relationship between parent and child obesity: a systematic review and meta-analysis. Clin Exp Pediatr. 2022;65:35–46.

PubMed  Google Scholar 

Magarey AM, Daniels LA, Boulton TJ, Cockington RA. Predicting obesity in early adulthood from childhood and parental obesity. Int J Obes. 2003;27:505–13.

CAS  Google Scholar 

Svensson V, Jacobsson JA, Fredriksson R, Danielsson P, Sobko T, Schiöth HB, et al. Associations between severity of obesity in childhood and adolescence, obesity onset and parental BMI: a longitudinal cohort study. Int J Obes. 2011;35:46–52.

CAS  Google Scholar 

Luca P, Birken C, Grewal P, Dettmer E, Hamilton J. Complex obesity. Curr Pediatr Rev. 2012;8:179–87.

Google Scholar 

Ornellas F, Carapeto PV, Mandarim-de-Lacerda CA, Aguila MB. Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies. J Pediatr. 2017;93:551–9.

Google Scholar 

Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, et al. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes. 2015;39:650–7.

CAS  Google Scholar 

Wardle J, Guthrie C, Sanderson S, Birch L, Plomin R. Food and activity preferences in children of lean and obese parents. Int J Obes. 2001;25:971–7.

CAS  Google Scholar 

Goran MI. Childhood obesity: causes, consequences, and intervention approaches. CRC Press, Boca Raton, 2016.

González-Domínguez Á, Visiedo F, Domínguez-Riscart J, Ruiz-Mateos B, Saez-Benito A, Lechuga-Sancho AM, et al. Blunted reducing power generation in erythrocytes contributes to oxidative stress in prepubertal obese children with insulin resistance. Antioxidants. 2021;10:244.

PubMed  PubMed Central  Google Scholar 

González-Domínguez Á, Visiedo F, Domínguez-Riscart J, Durán-Ruiz MC, Saez-Benito A, Lechuga-Sancho AM, et al. Catalase post-translational modifications as key targets in the control of erythrocyte redox homeostasis in children with obesity and insulin resistance. Free Radic Biol Med. 2022;191:40–7.

PubMed  Google Scholar 

Lechuga-Sancho AM, Gallego-Andujar D, Ruiz-Ocaña P, Visiedo FM, Saez-Benito A, Schwarz M, et al. Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age. PLoS ONE. 2018;13:e0191547.

PubMed  PubMed Central  Google Scholar 

González-Domínguez Á, Millán-Martínez M, Domínguez-Riscart J, Mateos RM, Lechuga-Sancho AM, González-Domínguez R. Altered metal homeostasis associates with inflammation, oxidative stress, impaired glucose metabolism, and dyslipidemia in the crosstalk between childhood obesity and insulin resistance. Antioxidants. 2022;11:2439.

PubMed  PubMed Central  Google Scholar 

González-Domínguez Á, González-Domínguez R. How far are we from reliable metabolomics-based biomarkers? The often-overlooked importance of addressing inter-individual variability factors. Biochim Biophys Acta Mol Basis Dis. 2024;1870:166910.

PubMed  Google Scholar 

González-Domínguez Á, Domínguez-Riscart J, Millán-Martínez M, Lechuga-Sancho AM, González-Domínguez R. Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and adolescents with obesity. Front Public Health. 2023;10:1016819.

PubMed  PubMed Central  Google Scholar 

González-Domínguez Á, Domínguez-Riscart J, Millán-Martínez M, Lechuga-Sancho AM, González-Domínguez R. Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones. Biofactors. 2023;49:849–60.

PubMed  Google Scholar 

González-Domínguez Á, Domínguez-Riscart J, Millán-Martínez M, Mateos-Bernal RM, Lechuga-Sancho AM, González-Domínguez R. Trace elements as potential modulators of puberty-induced amelioration of oxidative stress and inflammation in childhood obesity. Biofactors. 2023;49:820–30.

PubMed  Google Scholar 

González-Domínguez Á, Millán-Martínez M, Domínguez-Riscart J, Lechuga-Sancho AM, González-Domínguez R. Metal homeostasis and exposure in distinct phenotypic subtypes of insulin resistance among children with obesity. Nutrients. 2023;15:2347.

PubMed  PubMed Central  Google Scholar 

Hernández M, Castellet J, Narvaiza J, Rincón J, Ruiz I, Sánchez E, et al. Curvas y tablas de crecimiento (0-18 años). Instituto de Investigación sobre crecimiento y desarrollo; 1988.

González-Domínguez Á, Millán-Martínez M, Sánchez-Rodas D, Lechuga-Sancho AM, González-Domínguez R. Characterization of the plasmatic and erythroid multielemental biodistribution in childhood obesity using a high-throughput method for size fractionation of metal species. In: González-Domínguez R, editor. Mass spectrometry for metabolomics (Methods in molecular biology, 2571). New York: Humana Press; 2023. p. 123–32.

González-Domínguez Á, Estanyol-Torres N, Brunius C, Landberg R, González-Domínguez R. QComics: recommendations and guidelines for robust, easily implementable and reportable quality control of metabolomics data. Anal Chem. 2024. https://doi.org/10.1021/acs.analchem.3c03660.

Martínez-Villanueva J, González-Leal R, Argente J, Martos-Moreno GÁ. La obesidad parental se asocia con la gravedad de la obesidad infantil y de sus comorbilidades [Parental obesity is associated with the severity of childhood obesity and its comorbidities]. An Pediatr. 2019;90:224–31.

Google Scholar 

Dunn GA, Bale TL. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology. 2009;150:4999–5009.

CAS  PubMed  PubMed Central  Google Scholar 

Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature. 2010;467:963–6.

CAS  PubMed  Google Scholar 

Donnelly JM, Walsh JM, Horan MK, Mehegan J, Molloy EJ, Byrne DF, et al. Parental height and weight influence offspring adiposity at 2 years; findings from the ROLO Kids Birth Cohort Study. Am J Perinatol. 2021. https://doi.org/10.1055/s-0041-1740299.

Yang Z, Li Y, Dong B, Gao D, Wen B, Ma J. Relationship between parental overweight and obesity and childhood metabolic syndrome in their offspring: result from a cross-sectional analysis of parent-offspring trios in China. BMJ Open. 2020;10:e036332.

PubMed  PubMed Central  Google Scholar 

Werneck AO, Silva DRPD, Silva ECMD, Collings P, Ohara D, Fernandes RA, et al. Association of parents’ physical activity and weight status with obesity and metabolic risk of their offspring. Cienc Saude Colet. 2022;27:783–92.

Google Scholar 

Ornellas F, Souza-Mello V, Mandarim-de-Lacerda CA, Aguila MB. Programming of obesity and comorbidities in the progeny: lessons from a model of diet-induced obese parents. PLoS ONE. 2015;10:e0124737.

PubMed  PubMed Central  Google Scholar 

Thomas-Valdés S, Tostes MDGV, Anunciação PC, da Silva BP, Sant’Ana HMP. Association between vitamin deficiency and metabolic disorders related to obesity. Crit Rev Food Sci Nutr. 2017;57:3332–43.

PubMed  Google Scholar 

Harasymowicz NS, Choi YR, Wu CL, Iannucci L, Tang R, Guilak F. Intergenerational transmission of diet-induced obesity, metabolic imbalance, and osteoarthritis in mice. Arthritis Rheumatol. 2020;72:632–44.

CAS  PubMed  PubMed Central  Google Scholar 

Ornellas F, Souza-Mello V, Mandarim-de-Lacerda CA, Aguila MB. Combined parental obesity augments single-parent obesity effects on hypothalamus inflammation, leptin signaling (JAK/STAT), hyperphagia, and obesity in the adult mice offspring. Physiol Behav. 2016;153:47–55.

CAS  PubMed  Google Scholar 

Dash DK, Choudhury AK, Singh M, Mangaraj S, Mohanty BK, Baliarsinha AK. Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2018;12:285–9.

PubMed  Google Scholar 

Gu K, Li X, Xiang W, Jiang X. The relationship between serum copper and overweight/obesity: a meta-analysis. Biol Trace Elem Res. 2020;194:336–47.

CAS  PubMed  Google Scholar 

Ma J, Xie Y, Zhou Y, Wang D, Cao L, Zhou M, et al. Urinary copper, systemic inflammation, and blood lipid profiles: Wuhan-Zhuhai cohort study. Environ Pollut. 2020;267:115647.

CAS  PubMed  Google Scholar 

Barra NG, Anhê FF, Cavallari JF, Singh AM, Chan DY, Schertzer JD. Micronutrients impact the gut microbiota and blood glucose. J Endocrinol. 2021;250:R1–21.

CAS  PubMed  Google Scholar 

González-Domínguez Á, Visiedo-García FM, Domínguez-Riscart J, González-Domínguez R, Mateos RM, Lechuga-Sancho AM. Iron metabolism in obesity and metabolic syndrome. Int J Mol Sci. 2020;21:5529.

PubMed  PubMed Central  Google Scholar 

Backe MB, Moen IW, Ellervik C, Hansen JB, Mandrup-Poulsen T. Iron regulation of pancreatic beta-cell functions and oxidative stress. Annu Rev Nutr. 2016;36:241–73.

CAS  PubMed  Google Scholar 

Ma W, Jia L, Xiong Q, Feng Y, Du H. The role of iron homeostasis in adipocyte metabolism. Food Funct. 2021;12:4246–53.

CAS  PubMed  Google Scholar 

Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016;91:31–38.

PubMed  Google Scholar 

Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52:86–105.

PubMed  Google Scholar 

留言 (0)

沒有登入
gif