CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors

Shah SC, Gawron AJ, Mustafa RA, Piazuelo MB. Histologic subtyping of gastric intestinal metaplasia: overview and considerations for clinical practice. Gastroenterology. 2020;158(3):745–50.

Article  PubMed  Google Scholar 

Fennerty MB. Gastric intestinal metaplasia on routine endoscopic biopsy. Gastroenterology. 2003;125(2):586–90.

Article  PubMed  Google Scholar 

de Vries AC, Haringsma J, de Vries RA, ter Borg F, Nagtzaam NM, Steyerberg EW, et al. The use of clinical, histologic, and serologic parameters to predict the intragastric extent of intestinal metaplasia: a recommendation for routine practice. Gastrointest Endosc. 2009;70(1):18–25.

Article  PubMed  Google Scholar 

Matsukura N, Suzuki K, Kawachi T, Aoyagi M, Sugimura T, Kitaoka H, et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl Cancer Inst. 1980;65(2):231–40.

CAS  PubMed  Google Scholar 

Jass J, Filipe M. The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma. Histochem J. 1981;13:931–9.

Article  CAS  PubMed  Google Scholar 

Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol. 2010;105(3):493.

Article  PubMed  PubMed Central  Google Scholar 

Filipe MI, Muñoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer. 1994;57(3):324–9.

Article  CAS  PubMed  Google Scholar 

Rokkas T, Filipe M, Sladen G. Detection of an increased incidence of early gastric cancer in patients with intestinal metaplasia type III who are closely followed up. Gut. 1991;32(10):1110–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silva S, Filipe M. Intestinal metaplasia and its variants in the gastric mucosa of Portuguese subjects: a comparative analysis of biopsy and gastrectomy material. Hum Pathol. 1986;17(10):988–95.

Article  CAS  PubMed  Google Scholar 

Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965;122(3):467–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hammarström S, editor The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Seminars in cancer biology; 1999: Elsevier.

Liu J-N, Wang H-B, Zhou C-C, Hu S-Y. CEACAM5 has different expression patterns in gastric non-neoplastic and neoplastic lesions and cytoplasmic staining is a marker for evaluation of tumor progression in gastric adenocarcinoma. Pathology-Research and Practice. 2014;210(10):686–93.

Article  CAS  PubMed  Google Scholar 

Zhou J, Fan X, Chen N, Zhou F, Dong J, Nie Y, Fan D. Identification of CEACAM5 as a biomarker for prewarning and prognosis in gastric cancer. J Histochem Cytochem. 2015;63(12):922–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, et al. Apposition of fibroblasts with metaplastic gastric cells promotes dysplastic transition. Gastroenterology. 2023;165(2):374–90. https://doi.org/10.1053/j.gastro.2023.04.038.

Article  CAS  PubMed  Google Scholar 

Lipinski M, Parks DR, Rouse RV, Herzenberg LA. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci. 1981;78(8):5147–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lenárt S, Lenárt P, Šmarda J, Remšík J, Souček K, Beneš P. Trop2: Jack of all trades, master of none. Cancers. 2020;12(11):3328.

Article  PubMed  PubMed Central  Google Scholar 

Mühlmann G, Spizzo G, Gostner J, Zitt M, Maier H, Moser P, et al. TROP2 expression as prognostic marker for gastric carcinoma. J Clin Pathol. 2009;62(2):152–8.

Article  PubMed  Google Scholar 

Zhao W, Zhu H, Zhang S, Yong H, Wang W, Zhou Y, et al. Trop2 is overexpressed in gastric cancer and predicts poor prognosis. Oncotarget. 2016;7(5):6136.

Article  PubMed  Google Scholar 

Riera KM, Jang B, Min J, Roland JT, Yang Q, Fesmire WT, et al. Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol. 2020;251(3):336–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S, Jang B, Min J, Contreras-Panta EW, Presentation KS, Delgado AG, et al. Upregulation of AQP5 defines spasmolytic polypeptide-expressing metaplasia (SPEM) and progression to incomplete intestinal metaplasia. Cell Molec Gastroenterol Hepataol. 2022;13:199–217.

Article  Google Scholar 

Tsukamoto T, Mizoshita T, Tatematsu M. Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of transcription factors and stem cell intestinalization. Gastric Cancer. 2006;9:156–66.

Article  CAS  PubMed  Google Scholar 

Park YH, Kim N. Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer. J Cancer Prevent. 2015;20(1):25.

Article  Google Scholar 

Gawron AJ, Shah SC, Altayar O, Davitkov P, Morgan D, Turner K, Mustafa RA. AGA technical review on gastric intestinal metaplasia—natural history and clinical outcomes. Gastroenterology. 2020;158(3):705-31.e5.

Article  PubMed  Google Scholar 

Altayar O, Davitkov P, Shah SC, Gawron AJ, Morgan DR, Turner K, Mustafa RA. AGA technical review on gastric intestinal metaplasia—epidemiology and risk factors. Gastroenterology. 2020;158(3):732-44.e16.

Article  PubMed  Google Scholar 

Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, et al. Genomic and epigenomic profiling of high-risk intestinal metaplasia reveals molecular determinants of progression to gastric cancer. Cancer Cell. 2018;33(1):137-50.e5.

Article  CAS  PubMed  Google Scholar 

Filipe M, Potet F, Bogomoletz W, Dawson P, Fabiani B, Chauveinc P, et al. Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut. 1985;26(12):1319–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conchillo J, Houben G, De Bruine A, Stockbrügger R. Is type III intestinal metaplasia an obligatory precancerous lesion in intestinal-type gastric carcinoma? Eur J Cancer Prevent. 2001;10:307–12.

Article  CAS  Google Scholar 

Piazuelo MB, Camargo MC, Mera RM, Delgado AG, Bravo JC, Peek RM, et al. Gastric intestinal metaplasia type III and prospective risk of gastric cancer in colombia. Gastroenterology. 2017;152(5):S473.

Article  Google Scholar 

Dinis-Ribeiro M, Areia M, De Vries A, Marcos-Pinto R, Monteiro-Soares M, O’connor A, et al. Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Endoscopy. 2012;44(01):74–94.

Article  CAS  PubMed  Google Scholar 

Yamada H, Ikegami M, Shimoda T, Takagi N, Maruyama M. Long-term follow-up study of gastric adenoma/dysplasia. Endoscopy. 2004;36(05):390–6.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif