This work was supported in part by the Chugai Foundation for Innovative Drug Discovery Science: C-FINDs (2023-CF-01 to HK), University of the Ryukyus Research Project Promotion Grant for Foreign Researchers (19SP07101 to SL), the Uruma Fund for the Promotion of Science (to SL), the National Natural Science Foundation of China (82104025 to SL and 22377042 to DM), the Senior Talent Foundation of Jiangsu University (5501290012 to SL and 5501290011 to DM), the Jiangsu Provincial Double-Innovation Doctor Program (JSSCBS20221203 to SL and JSSCBS20221208 to DM) and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (23H04882 to HK).