Heald AH, Martin JL, Payton T, Khalid L, Anderson SG, Narayanan RP, De Hert M, Yung A, Livingston M. Changes in metabolic parameters in patients with severe mental illness over a 10-year period: a retrospective cohort study. Aust NZ J Psychiatry. 2017;51:75.

Article  Google Scholar 

Zhang JP, Gallego JA, Robinson DG, Malhotra AK, Kane JM, Correll CU. Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis. Int J Neuropsychopharmacol. 2013;16:1205–18.

Article  PubMed  Google Scholar 

Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999;156:1686–96.

Article  PubMed  Google Scholar 

Brandl EJ, Kennedy JL, Müller DJ. Pharmacogenetics of antipsychotics. Can J Psychiatry. 2014;59:76–88.

Article  PubMed  PubMed Central  Google Scholar 

Cooper SJ, Reynolds GP, With expert co-authors (in alphabetical order), Barnes T, England E, Haddad PM, Heald A, Holt R, Lingford-Hughes A, Osborn D, McGowan O, Patel MX, Paton C, Reid P, Shiers D, Smith J. BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment. J Psychopharmacol. 2016;30:717–48.

Article  PubMed  Google Scholar 

Correll CU, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, et al. Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study. JAMA Psychiat. 2014;71:1350–63.

Article  Google Scholar 

Shrivastava A, Johnston ME. Weight-gain in psychiatric treatment: risks, implications, and strategies for prevention and management. Mens Sana Monogr. 2010;8:53–68.

Article  PubMed  PubMed Central  Google Scholar 

Harrison RNS, Gaughran F, Murray RM, Lee SH, Cano JP, Dempster D, Curtis CJ, Dima D, Patel H, de Jong S, Breen G. Development of multivariable models to predict change in Body Mass Index within a clinical trial population of psychotic individuals. Sci Rep. 2017;7:14738.

Article  PubMed  PubMed Central  Google Scholar 

https://gmwearebettertogether.com/research-and-planning/. Accessed 3 July 2023.

Campforts B, Drukker M, Crins J, van Amelsvoort T, Bak M. Association between antipsychotic medication and clinically relevant weight change: meta-analysis. BJPsych Open. 2023;9(1): e18.

Article  PubMed  PubMed Central  Google Scholar 

Anderson SG, Livingston M, Couchman L, Smith DJ, Connolly M, Miller J, Flanagan RJ, Heald AH. Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey. Ann Gen Psychiatry. 2015;14(14):39.

Article  PubMed  PubMed Central  Google Scholar 

Heald A, Azadbakht N, Geary B, Conen S, Fachim H, Lee DCH, Geifman N, Farman S, Howes O, Whetton A, Deakin B. Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis. Clin Proteomics. 2020;17:38.

Article  PubMed  PubMed Central  Google Scholar 

Heald AH, Stedman M, Farman S, Khine C, Davies M, De Hert M, Taylor D. Links between the amount of antipsychotic medication prescribed per population at general practice level, local demographic factors and medication selection. BMC Psychiatry. 2020;20:528.

Article  PubMed  PubMed Central  Google Scholar 

Heald A, Livingston M, Yung A, De Hert MA. Prescribing in schizophrenia and psychosis: Increasing polypharmacy over time. Hum Psychopharmacol. 2017;32(2): e2579.

Article  Google Scholar 

Remington G, Hahn MK, Agarwal SM, Chintoh A, Agid O. Schizophrenia: antipsychotics and drug development. Behav Brain Res. 2021;414: 113507.

Article  PubMed  Google Scholar 

Roerig JL, Steffen KJ, Mitchell JE. Atypical antipsychotic-induced weight gain: insights into mechanisms of action. CNS Drugs. 2011;25:1035–59.

Article  PubMed  Google Scholar 

Heald AH, Stedman M, Daly C, Warner-Levy JJ, Livingston M, Hussain L, Anderson S. First episode psychosis and weight gain a longitudinal perspective in Cheshire UK: a comparison between individuals with nonaffective versus affective psychosis. Cardiovasc Endocrinol Metab. 2023;12(3): e0286.

Article  PubMed  PubMed Central  Google Scholar 

Dayabandara M, Hanwella R, Ratnatunga S, Seneviratne S, Suraweera C, de Silva VA. Antipsychotic-associated weight gain: management strategies and impact on treatment adherence. Neuropsychiatr Dis Treat. 2017;13:2231–41.

Article  PubMed  PubMed Central  Google Scholar 

Weiden PJ, Mackell JA, McDonnell DD. Obesity as a risk factor for antipsychotic noncompliance. Schizophr Res. 2004;66:51–7.

Article  PubMed  Google Scholar 

Manschreck TC, Boshes RA. The CATIE schizophrenia trial: results, impact, controversy. Harv Rev Psychiatry. 2007;15:245–58.

Article  PubMed  Google Scholar 

Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353:1209–23.

Article  PubMed  Google Scholar 

Kinon BJ, Basson BR, Gilmore JA, Tollefson GD. Long-term olanzapine treatment: weight change and weight-related health factors in schizophrenia. J Clin Psychiatry. 2001;62:92–100.

Article  PubMed  Google Scholar 

Jónsdóttir H, Opjordsmoen S, Birkenaes AB, Simonsen C, Engh JA, Ringen PA, Vaskinn A, Friis S, Sundet K, Andreassen OA. Predictors of medication adherence in patients with schizophrenia and bipolar disorder. Acta Psychiatr Scand. 2013;127:23–33.

Article  PubMed  Google Scholar 

Velligan DI, Weiden PJ, Sajatovic M, Scott J, Carpenter D, Ross R, Docherty JP, Expert Consensus Panel on Adherence Problems in Serious and Persistent Mental Illness. The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry. 2009;70(Suppl 4):1–46.

Article  PubMed  Google Scholar 

Puhl RM, Himmelstein MS, Pearl RL. Weight stigma as a psychosocial contributor to obesity. Am Psychol. 2020;75(2):274–89.

Article  PubMed  Google Scholar 

Seidell JC. Societal and personal costs of obesity. Exp Clin Endocrinol Diabetes. 1998;106(2):7–9.

PubMed  Google Scholar 

Lester H, Marshall M, Jones P, Fowler D, Amos T, Khan N, Birchwood M. Views of young people in early intervention services for first-episode psychosis in England. Psychiatr Serv. 2011;62:882–7.

Article  PubMed  Google Scholar 

Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7:64–77.

Article  PubMed  PubMed Central  Google Scholar 

Firth J, Siddiqi N, Koyanagi A, Siskind D, Rosenbaum S, Galletly C, Allan S, Caneo C, Carney R, Carvalho AF, Chatterton ML, Correll CU, Curtis J, Gaughran F, Heald A, Hoare E, Jackson SE, Kisely S, Lovell K, Maj M, McGorry PD, Mihalopoulos C, Myles H, O’Donoghue B, Pillinger T, Sarris J, Schuch FB, Shiers D, Smith L, Solmi M, Suetani S, Taylor J, Teasdale SB, Thornicroft G, Torous J, Usherwood T, Vancampfort D, Veronese N, Ward PB, Yung AR, Killackey E, Stubbs B. The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. Lancet Psychiatry. 2019;6:675.

Article  PubMed  Google Scholar 

Barton BB, Segger F, Fischer K, Obermeier M, Musil R. Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis. Expert Opin Drug Saf. 2020;19(3):295–314.

Article  PubMed  Google Scholar 

Ventriglio A, Gentile A, Stella E, Bellomo A. Metabolic issues in patients affected by schizophrenia: clinical characteristics and medical management. Front Neurosci. 2013;9:297.

Google Scholar 

Waite F, Langman A, Mulhall S, Glogowska M, Hartmann-Boyce J, Aveyard P, Lennox B, Oxford Cognitive Approaches to Psychosis Patient Advisory Group, Kabir T, Freeman D. The psychological journey of weight gain in psychosis. Psychol Psychother. 2022;95:525–40.

Article  PubMed  PubMed Central  Google Scholar 

Bak M, Drukker M, Cortenraad S, Vandenberk E, Guloksuz S. Antipsychotics result in more weight gain in antipsychotic naive patients than in patients after antipsychotic switch and weight gain is irrespective of psychiatric diagnosis: a meta-analysis. PLoS ONE. 2021;16: e0244944.

Article  PubMed  PubMed Central  Google Scholar