Exploring the Mechanistic Link Between Obesity and Heart Failure

Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. NCHS Data Brief, no 360. Hyattsville: National Center for Health Statistics; 2020

Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, et al. Projected U.S. state-level prevalence of adult obesity and severe obesity. N Engl J Med. 2019;381(25):2440–50.

Article  PubMed  Google Scholar 

• Ndumele CE, Matsushita K, Lazo M, Bello N, Blumenthal RS, Gerstenblith G, et al. Obesity and subtypes of incident cardiovascular disease. J Am Heart Assoc. 2016;5(8):e003921. This study demonstrates that while traditional CVD risk factors account for the associations of obesity with incident CHD and stroke, greater degrees of obesity have an independent, dose-response relationship with future HF risk.

Dunlay SM, Roger VL. Understanding the epidemic of heart failure: past, present, and future. Curr Heart Fail Rep. 2014;11(4):404–15.

Article  PubMed  PubMed Central  Google Scholar 

Fang M, Wang D, Coresh J, Selvin E. Trends in diabetes treatment and control in U.S. adults, 1999-2018. N Engl J Med. 2021;384(23):2219–28.

Article  PubMed  PubMed Central  Google Scholar 

Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013;6(3):606–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taylor CJ, Ordonez-Mena JM, Roalfe AK, Lay-Flurrie S, Jones NR, Marshall T, et al. Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study. BMJ. 2019;364:l223.

Article  PubMed  PubMed Central  Google Scholar 

Khan SS, Ning H, Wilkins JT, Allen N, Carnethon M, Berry JD, et al. Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity. JAMA Cardiol. 2018;3(4):280–7.

Article  PubMed  PubMed Central  Google Scholar 

Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347(5):305–13.

Article  PubMed  Google Scholar 

Reis JP, Allen N, Gunderson EP, Lee JM, Lewis CE, Loria CM, et al. Excess body mass index- and waist circumference-years and incident cardiovascular disease: the CARDIA study. Obesity (Silver Spring). 2015;23(4):879–85.

Article  PubMed  PubMed Central  Google Scholar 

Reis JP, Allen N, Gibbs BB, Gidding SS, Lee JM, Lewis CE, et al. Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: the CARDIA study. Obesity (Silver Spring). 2014;22(11):2434–40.

Article  PubMed  PubMed Central  Google Scholar 

Alpert MA, Lambert CR, Panayiotou H, Terry BE, Cohen MV, Massey CV, et al. Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss. Am J Cardiol. 1995;76(16):1194–7.

Article  CAS  PubMed  Google Scholar 

Ndumele CE, Cobb L, Lazo M, Bello NA, Shah A, Nambi V, et al. Weight history and subclinical myocardial damage. Clin Chem. 2018;64(1):201–9.

Article  CAS  PubMed  Google Scholar 

Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, Somers VK, Erwin PJ, et al. Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obes. 2010;34(5):791–9.

Article  CAS  Google Scholar 

Nicklas BJ, Cesari M, Penninx BW, Kritchevsky SB, Ding J, Newman A, et al. Abdominal obesity is an independent risk factor for chronic heart failure in older people. J Am Geriatr Soc. 2006;54(3):413–20.

Article  PubMed  Google Scholar 

Borne Y, Hedblad B, Essen B, Engstrom G. Anthropometric measures in relation to risk of heart failure hospitalization: a Swedish population-based cohort study. Eur J Public Health. 2014;24(2):215–20.

Article  PubMed  Google Scholar 

Leopoldo AS, Sugizaki MM, Lima-Leopoldo AP, do Nascimento AF, Luvizotto Rde A, de Campos DH, et al. Cardiac remodeling in a rat model of diet-induced obesity. Can J Cardiol. 2010;26(8):423–9.

Article  PubMed  PubMed Central  Google Scholar 

Majane OH, Vengethasamy L, du Toit EF, Makaula S, Woodiwiss AJ, Norton GR. Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats. Hypertension. 2009;54(6):1376–83.

Article  CAS  PubMed  Google Scholar 

Alex L, Russo I, Holoborodko V, Frangogiannis NG. Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2018;315(4):H934–H49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowen TS, Brauer D, Rolim NPL, Baekkerud FH, Kricke A, Ormbostad Berre AM, et al. Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction. J Am Heart Assoc. 2017;6(10):e006416.

Martinez-Martinez E, Lopez-Andres N, Jurado-Lopez R, Rousseau E, Bartolome MV, Fernandez-Celis A, et al. Galectin-3 participates in cardiovascular remodeling associated with obesity. hypertension. 2015;66(5):961–9.

Article  CAS  PubMed  Google Scholar 

Aurigemma GP, de Simone G, Fitzgibbons TP. Cardiac remodeling in obesity. Circ Cardiovasc Imaging. 2013;6(1):142–52.

Article  PubMed  Google Scholar 

Neeland IJ, Gupta S, Ayers CR, Turer AT, Rame JE, Das SR, et al. Relation of regional fat distribution to left ventricular structure and function. Circ Cardiovasc Imaging. 2013;6(5):800–7.

Article  PubMed  PubMed Central  Google Scholar 

Dunlay SM, Roger VL, Redfield MM. Epidemiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2017;14(10):591–602.

Article  PubMed  Google Scholar 

Owan TE, Redfield MM. Epidemiology of diastolic heart failure. Prog Cardiovasc Dis. 2005;47(5):320–32.

Article  PubMed  Google Scholar 

Packer M, Lam CSP, Lund LH, Redfield MM. Interdependence of atrial fibrillation and heart failure with a preserved ejection fraction reflects a common underlying atrial and ventricular myopathy. Circulation. 2020;141(1):4–6.

Article  PubMed  Google Scholar 

Ergatoudes C, Schaufelberger M, Andersson B, Pivodic A, Dahlstrom U, Fu M. Non-cardiac comorbidities and mortality in patients with heart failure with reduced vs. preserved ejection fraction: a study using the Swedish Heart Failure Registry. Clin Res Cardiol. 2019;108(9):1025–33.

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Lima JAC, Post WS, Szklo M. Associations of time-varying obesity and metabolic syndrome with risk of incident heart failure and its subtypes: findings from the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2021;338:127–35.

Article  PubMed  Google Scholar 

Cohen LP, Vittinghoff E, Pletcher MJ, Allen NB, Shah SJ, Wilkins JT, et al. Association of midlife cardiovascular risk factors with the risk of heart failure subtypes later in life. J Card Fail. 2021;27(4):435–44.

Article  PubMed  Google Scholar 

Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, et al. Relationship between physical activity, body mass index, and risk of heart failure. Journal of the American College of Cardiology. 2017;69(9):1129–42.

Article  PubMed  PubMed Central  Google Scholar 

Ho JE, Lyass A, Lee DS, Vasan RS, Kannel WB, Larson MG, et al. Predictors of new-onset heart failure: differences in preserved versus reduced ejection fraction. Circ Heart Fail. 2013;6(2):279–86.

Article  PubMed  Google Scholar 

Haass M, Kitzman DW, Anand IS, Miller A, Zile MR, Massie BM, et al. Body mass index and adverse cardiovascular outcomes in heart failure patients with preserved ejection fraction. Circulation. Heart Fail. 2011;4(3):324–31.

Article  Google Scholar 

Khalid U, Wruck LM, Quibrera PM, Bozkurt B, Nambi V, Virani SS, et al. BNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: the atherosclerosis risk in communities surveillance study. Int J Cardiol. 2017;233:61–6.

Article  PubMed  PubMed Central  Google Scholar 

• Rao VN, Zhao D, Allison MA, Guallar E, Sharma K, Criqui MH, et al. Adiposity and incident heart failure and its subtypes: MESA (Multi-Ethnic Study of Atherosclerosis). JACC Heart Fail. 2018;6(12):999–1007. This study demonstrates the strong association between greater degrees of visceral fat and future HF risk, particularly the HFpEF phenotype. Conversely, a greater degree of subcutaneous fat is not independently associated with incident HF.

Article  PubMed  PubMed Central  Google Scholar 

Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, et al. The Association of obesity and cardiometabolic traits with incident HFpEF and HFrEF. JACC Heart Fail. 2018;6(8):701–9.

Article  PubMed  PubMed Central  Google Scholar 

• Patel KV, Bahnson JL, Gaussoin SA, Johnson KC, Pi-Sunyer X, White U, et al. Association of baseline and longitudinal changes in body composition measures with risk of heart failure and myocardial infarction in type 2 diabetes: findings from the Look AHEAD Trial. Circulation. 2020;142(25):2420–30. This secondary analysis of the LOOK Ahead trial demonstrates that lifestyle change-induced decline in fat mass, but not in lean mass, is associated with lower HF risk.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA Guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895–e1032.

PubMed  Google Scholar 

Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A. 2000;97(4):1784–9.

Article  CAS  PubMed  PubMed Central 

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