Apoptosis Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

推出的年份: 2006(1999)

树号: D08.811.682.608.047, D12.644.360.075.311, D12.776.157.687.063, D12.776.331.161, D12.776.476.075.311, D12.776.660.720.063

MeSH 单一 ID: D051033

进入的组:

Apoptosis-Inducing Factor
Mitochondrial Apoptosis-Inducing Factor
Apoptosis-Inducing Factor, Mitochondrial
Mitochondrial Apoptosis Inducing Factor
AIF Apoptosis Regulatory Protein

All MeSH Categories
- Chemicals and Drugs Category
  - Enzymes and Coenzymes [D08]
    - Enzymes [D08.811]
      - Oxidoreductases [D08.811.682]
        
        NADH, NADPH Oxidoreductases [D08.811.682.608]
        
        Apoptosis Inducing Factor [D08.811.682.608.047]
        
        Cytochrome Reductases [D08.811.682.608.191] add_circle
        
        Electron Transport Complex I [D08.811.682.608.504] add_circle
        
        NADH Tetrazolium Reductase [D08.811.682.608.530]
        
        NADP Transhydrogenases [D08.811.682.608.540] add_circle
        
        NADPH Dehydrogenase [D08.811.682.608.550]
        
        NADPH Oxidases [D08.811.682.608.575] add_circle
        
        Quinone Reductases [D08.811.682.608.800] add_circle

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Peptides [D12.644]
      - Intracellular Signaling Peptides and Proteins [D12.644.360]
        
        Apoptosis Regulatory Proteins [D12.644.360.075]
        
        Apoptosis Inducing Factor [D12.644.360.075.311]
        
        Bcl-2-Like Protein 11 [D12.644.360.075.323]
        
        Beclin-1 [D12.644.360.075.335]
        
        CARD Signaling Adaptor Proteins [D12.644.360.075.358] add_circle
        
        DCC Receptor [D12.644.360.075.413]
        
        Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.075.421] add_circle
        
        Inhibitor of Apoptosis Proteins [D12.644.360.075.437] add_circle
        
        Proto-Oncogene Proteins c-bcl-2 [D12.644.360.075.718] add_circle

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Carrier Proteins [D12.776.157]
        
        Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
        
        Apoptosis Inducing Factor [D12.776.157.687.063]
        
        Ataxia Telangiectasia Mutated Proteins [D12.776.157.687.125]
        
        CCCTC-Binding Factor [D12.776.157.687.157]
        
        Centromere Protein A [D12.776.157.687.173]
        
        Centromere Protein B [D12.776.157.687.188]
        
        Cyclin-Dependent Kinase Inhibitor p21 [D12.776.157.687.250]
        
        DNA (Cytosine-5-)-Methyltransferase 1 [D12.776.157.687.313]
        
        DNA Topoisomerases, Type I [D12.776.157.687.375]
        
        DNA-Activated Protein Kinase [D12.776.157.687.438]
        
        Heat Shock Transcription Factors [D12.776.157.687.450]
        
        Heterogeneous Nuclear Ribonucleoprotein A1 [D12.776.157.687.462]
        
        Histones [D12.776.157.687.485]
        
        Ku Autoantigen [D12.776.157.687.493]
        
        MRE11 Homologue Protein [D12.776.157.687.495]
        
        Myristoylated Alanine-Rich C Kinase Substrate [D12.776.157.687.496]
        
        NF-kappa B p52 Subunit [D12.776.157.687.497]
        
        Nicotinamide-Nucleotide Adenylyltransferase [D12.776.157.687.499]
        
        Nitric Oxide Synthase Type II [D12.776.157.687.575]
        
        Telomerase [D12.776.157.687.613]
        
        Tumor Suppressor Protein p53 [D12.776.157.687.650]
        
        Werner Syndrome Helicase [D12.776.157.687.750]
        
        X-ray Repair Cross Complementing Protein 1 [D12.776.157.687.813]
        
        Xeroderma Pigmentosum Group A Protein [D12.776.157.687.875]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Flavoproteins [D12.776.331]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Intracellular Signaling Peptides and Proteins [D12.776.476]
        
        Apoptosis Regulatory Proteins [D12.776.476.075]
        
        Apoptosis Inducing Factor [D12.776.476.075.311]
        
        Bcl-2-Like Protein 11 [D12.776.476.075.323]
        
        Beclin-1 [D12.776.476.075.335]
        
        CARD Signaling Adaptor Proteins [D12.776.476.075.358] add_circle
        
        Caspases [D12.776.476.075.405] add_circle
        
        DCC Receptor [D12.776.476.075.413]
        
        Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.075.421] add_circle
        
        High-Temperature Requirement A Serine Peptidase 2 [D12.776.476.075.429]
        
        Inhibitor of Apoptosis Proteins [D12.776.476.075.437] add_circle
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.476.075.718] add_circle

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Nuclear Proteins [D12.776.660]
        
        Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
        
        Apoptosis Inducing Factor [D12.776.660.720.063]
        
        Ataxia Telangiectasia Mutated Proteins [D12.776.660.720.125]
        
        CCCTC-Binding Factor [D12.776.660.720.157]
        
        Centromere Protein A [D12.776.660.720.173]
        
        Centromere Protein B [D12.776.660.720.188]
        
        Cyclin-Dependent Kinase Inhibitor p21 [D12.776.660.720.250]
        
        DNA (Cytosine-5-)-Methyltransferase 1 [D12.776.660.720.313]
        
        DNA Topoisomerases, Type I [D12.776.660.720.375]
        
        DNA-Activated Protein Kinase [D12.776.660.720.438]
        
        Heat Shock Transcription Factors [D12.776.660.720.462]
        
        Histones [D12.776.660.720.485]
        
        Ku Autoantigen [D12.776.660.720.493]
        
        MRE11 Homologue Protein [D12.776.660.720.495]
        
        Myristoylated Alanine-Rich C Kinase Substrate [D12.776.660.720.496]
        
        NF-kappa B p52 Subunit [D12.776.660.720.497]
        
        Nicotinamide-Nucleotide Adenylyltransferase [D12.776.660.720.499]
        
        Nitric Oxide Synthase Type II [D12.776.660.720.575]
        
        Telomerase [D12.776.660.720.613]
        
        Tumor Suppressor Protein p53 [D12.776.660.720.650]
        
        Werner Syndrome Helicase [D12.776.660.720.750]
        
        X-ray Repair Cross Complementing Protein 1 [D12.776.660.720.813]
        
        Xeroderma Pigmentosum Group A Protein [D12.776.660.720.875]

MeSH 搜索器

Apoptosis Inducing Factor

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