Liu S, Li Y, Zeng X, Wang H, Yin P, Wang L, et al. Burden of Cardiovascular Diseases in China, 1990–2016: Findings From the 2016 Global Burden of Disease Study. JAMA cardiology. 2019;4(4):342–52.
Article PubMed PubMed Central Google Scholar
Townsend N, Kazakiewicz D, Lucy Wright F, Timmis A, Huculeci R, Torbica A, et al. Epidemiology of cardiovascular disease in Europe. Nature reviews Cardiology. 2022;19(2):133–43.
Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. Journal of the American College of Cardiology. 2020;76(25):2982–3021.
Article PubMed PubMed Central Google Scholar
Hahad O, Frenis K, Kuntic M, Daiber A, Münzel T. Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure. International journal of molecular sciences. 2021;22(5).
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet (London, England). 2013;381(9868):752–62.
Morley JE. Frailty Fantasia. Journal of the American Medical Directors Association. 2017;18(10):813–5.
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants. The Lancet Public health. 2018;3(7):e323–e32.
Article PubMed PubMed Central Google Scholar
Boyd CM, Xue QL, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. The American journal of medicine. 2005;118(11):1225–31.
Li G, Prior JC, Leslie WD, Thabane L, Papaioannou A, Josse RG, et al. Frailty and Risk of Fractures in Patients With Type 2 Diabetes. Diabetes care. 2019;42(4):507–13.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. The journals of gerontology Series A, Biological sciences and medical sciences. 2001;56(3):M146–56.
Article CAS PubMed Google Scholar
Ji S, Baek JY, Jin T, Lee E, Jang IY, Jung HW. Association Between Changes in Frailty Index and Clinical Outcomes: An Observational Cohort Study. Clinical interventions in aging. 2022;17:627–36.
Article PubMed PubMed Central Google Scholar
Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet (London, England). 2019;394(10206):1365–75.
Fan J, Yu C, Guo Y, Bian Z, Sun Z, Yang L, et al. Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study. The Lancet Public health. 2020;5(12):e650–e60.
Article PubMed PubMed Central Google Scholar
Hawkley LC, Cacioppo JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Annals of behavioral medicine: a publication of the Society of Behavioral Medicine. 2010;40(2):218–27.
Chalise HN, Kai I, Saito T. Social support and its correlation with loneliness: a cross-cultural study of Nepalese older adults. International journal of aging & human development. 2010;71(2):115–38.
Yang K, Victor CR. The prevalence of and risk factors for loneliness among older people in China. Ageing and Society. 2008;28(3):305–27.
Luo Y, Waite LJ. Loneliness and mortality among older adults in China. The journals of gerontology Series B, Psychological sciences and social sciences. 2014;69(4):633–45.
Article PubMed PubMed Central Google Scholar
Hakulinen C, Pulkki-Råback L, Virtanen M, Jokela M, Kivimäki M, Elovainio M. Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality: UK Biobank cohort study of 479 054 men and women. Heart (British Cardiac Society). 2018;104(18):1536–42.
Perissinotto CM, Stijacic Cenzer I, Covinsky KE. Loneliness in older persons: a predictor of functional decline and death. Archives of internal medicine. 2012;172(14):1078–83.
Article PubMed PubMed Central Google Scholar
Kojima G, Taniguchi Y, Aoyama R, Tanabe M. Associations between loneliness and physical frailty in community-dwelling older adults: A systematic review and meta-analysis. Ageing research reviews. 2022;81:101705.
Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS). International journal of epidemiology. 2014;43(1):61–8.
Zheng X, Jiang M, Ren X, Han L. The longitudinal association of remnant cholesterol with diabetes in middle-aged and elderly Chinese: A nationwide population-based cohort study. Journal of diabetes and its complications. 2023;37(1):108360.
Article CAS PubMed Google Scholar
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC geriatrics. 2008;8:24.
Article PubMed PubMed Central Google Scholar
Liu X, Dai G, He Q, Ma H, Hu H. Frailty Index and Cardiovascular Disease among Middle-Aged and Older Chinese Adults: A Nationally Representative Cross-Sectional and Follow-Up Study. Journal of cardiovascular development and disease. 2022;9(7).
Barker FJ, Davies JI, Gomez-Olive FX, Kahn K, Matthews FE, Payne CF, et al. Developing and evaluating a frailty index for older South Africans-findings from the HAALSI study. Age and ageing. 2021;50(6):2167–73.
Article PubMed PubMed Central Google Scholar
Oude Voshaar RC, Jeuring HW, Borges MK, van den Brink RHS, Marijnissen RM, Hoogendijk EO, et al. Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study. BMC medicine. 2021;19(1):29.
Article CAS PubMed PubMed Central Google Scholar
Rabin BS. Social networks and dementia. Lancet (London, England). 2000;356(9223):76–7.
Article CAS PubMed Google Scholar
Tabue Teguo M, Simo-Tabue N, Stoykova R, Meillon C, Cogne M, Amiéva H, et al. Feelings of Loneliness and Living Alone as Predictors of Mortality in the Elderly: The PAQUID Study. Psychosomatic medicine. 2016;78(8):904–9.
Xie W, Zheng F, Yan L, Zhong B. Cognitive Decline Before and After Incident Coronary Events. Journal of the American College of Cardiology. 2019;73(24):3041–50.
Zheng F, Yan L, Zhong B, Yang Z, Xie W. Progression of cognitive decline before and after incident stroke. Neurology. 2019;93(1):e20–e8.
Sha S, Pan Y, Xu Y, Chen L. Associations between loneliness and frailty among older adults: Evidence from the China Health and Retirement Longitudinal Study. BMC geriatrics. 2022;22(1):537.
Article PubMed PubMed Central Google Scholar
Valtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart (British Cardiac Society). 2016;102(13):1009–16.
Afilalo J. Frailty in Patients with Cardiovascular Disease: Why, When, and How to Measure. Current cardiovascular risk reports. 2011;5(5):467–72.
Article PubMed PubMed Central Google Scholar
Veronese N, Cereda E, Stubbs B, Solmi M, Luchini C, Manzato E, et al. Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing research reviews. 2017;35:63–73.
Article PubMed PubMed Central Google Scholar
Hou Y, Xu C, Lu Q, Zhang Y, Cao Z, Li S, et al. Associations of frailty with cardiovascular disease and life expectancy: A prospective cohort study. Archives of gerontology and geriatrics. 2022;99:104598.
Hoogendijk EO, Smit AP, van Dam C, Schuster NA, de Breij S, Holwerda TJ, et al. Frailty Combined with Loneliness or Social Isolation: An Elevated Risk for Mortality in Later Life. Journal of the American Geriatrics Society. 2020;68(11):2587–93.
Article PubMed PubMed Central Google Scholar
Kulminski AM, Ukraintseva SV, Culminskaya IV, Arbeev KG, Land KC, Akushevich L, et al. Cumulative deficits and physiological indices as predictors of mortality and long life. The journals of gerontology Series A, Biological sciences and medical sciences. 2008;63(10):1053–9.
Li X, Ploner A, Karlsson IK, Liu X, Magnusson PKE, Pedersen NL, et al. The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study. BMC medicine. 2019;17(1):94.
Article PubMed PubMed Central Google Scholar
Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, et al. Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing research reviews. 2016;31:1–8.
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