Thijs RD, Surges R, O’Brien TJ, Sander JW (2019) Epilepsy in adults. The Lancet 393(10172):689–701

Article  Google Scholar 

Miller WR, Von Gaudecker J, Tanner A, Buelow JM (2020) Epilepsy self-management during a pandemic: experiences of people with Epilepsy. Epilepsy Behav 111:107238

Article  PubMed  PubMed Central  Google Scholar 

Cretin B (2021) Treatment of seizures in older patients with Dementia. Drugs Aging 38(3):181–192

Article  PubMed  Google Scholar 

Fisher RS, Acharya JN, Baumer FM, French JA, Parisi P, Solodar JH et al (2022) Visually sensitive seizures: an updated review by the Epilepsy Foundation. Epilepsia 63(4):739–768

Article  PubMed  Google Scholar 

Li RJ, Liu Y, Liu HQ, Li J (2020) Ketogenic diets and protective mechanisms in Epilepsy, metabolic disorders, cancer, neuronal loss, and muscle and nerve degeneration. J Food Biochem 44(3):e13140

Article  PubMed  Google Scholar 

Rubio C, Piñón E, Molina-García J, Portilla A, Osornio MR (2023) Participation of na + channels in Epilepsy: a bibliometric analysis of the Scientific production in the World. Adv Bioeng Biomedical Sci Res 6(3):33–41

Google Scholar 

Steriade C, Britton J, Dale RC, Gadoth A, Irani SR, Linnoila J et al (2020) Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune-associated Epilepsy: conceptual definitions. Epilepsia 61(7):1341–1351

Article  PubMed  Google Scholar 

Zheng Z, Zhang L, Qu Y, Xiao G, Li S, Bao S et al (2018) Mesenchymal stem cells protect against hypoxia-ischemia brain damage by enhancing autophagy through brain derived neurotrophic factor/mammalin target of rapamycin signaling pathway. Stem Cells 36(7):1109–1121

Article  CAS  PubMed  Google Scholar 

Ali SO, Shahin NN, Safar MM, Rizk SM (2019) Therapeutic potential of endothelial progenitor cells in a rat model of Epilepsy: role of autophagy. J Adv Res 18:101–112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castrén E, Monteggia LM (2021) Brain-derived neurotrophic factor signaling in depression and antidepressant action. Biol Psychiatry 90(2):128–136

Article  PubMed  Google Scholar 

Gao L, Zhang Y, Sterling K, Song W (2022) Brain-derived neurotrophic factor in Alzheimer’s Disease and its pharmaceutical potential. Translational Neurodegeneration 11(1):1–34

Article  CAS  Google Scholar 

McGregor CE, English AW (2019) The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met. Front Cell Neurosci 12:522

Article  PubMed  PubMed Central  Google Scholar 

Chaldarov GN, Tonchev AB, Aloe L (2009) NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria 44(2):79–87

Google Scholar 

Lu B, Nagappan G, Guan X, Nathan PJ, Wren P (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative Diseases. Nat Rev Neurosci 14(6):401–416

Article  CAS  PubMed  Google Scholar 

Guerrera CS, Furneri G, Grasso M, Caruso G, Castellano S, Drago F et al (2020) Antidepressant Drugs and physical activity: a possible synergism in the treatment of major depression? Front Psychol 11:857

Article  PubMed  PubMed Central  Google Scholar 

Miao Z, Wang Y, Sun Z (2020) The relationships between stress, mental disorders, and epigenetic regulation of BDNF. Int J Mol Sci 21(4):1375

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldhardt MG, Andreia A, Dorneles GP, da Silva IR, Pochmann D, Peres A et al (2019) Does a single bout of exercise impacts BDNF, oxidative stress and epigenetic markers in spinal cord injury patients. Funct Neurol 34:158–166

PubMed  Google Scholar 

Ventriglia M, Zanardini R, Bonomini C, Zanetti O, Volpe D, Pasqualetti P et al (2013) Serum brain-derived neurotrophic factor levels in different neurological diseases. BioMed research international 2013

Diniz BS, Teixeira AL (2011) Brain-derived neurotrophic factor and Alzheimer’s Disease: physiopathology and beyond. Neuromolecular Med 13:217–222

Article  CAS  PubMed  Google Scholar 

Murer M, Boissiere F, Yan Q, Hunot S, Villares J, Faucheux B et al (1999) An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer’s Disease. Neuroscience 88(4):1015–1032

Article  CAS  PubMed  Google Scholar 

Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S (2004) BDNF is induced by wild-type α-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem Biophys Res Commun 318(1):113–118

Article  CAS  PubMed  Google Scholar 

Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative Diseases. Nat Reviews Neurol 5(6):311–322

Article  CAS  Google Scholar 

Fusar-Poli L, Aguglia A, Amerio A, Orsolini L, Salvi V, Serafini G et al (2021) Peripheral BDNF levels in psychiatric patients with and without a history of Suicide attempt: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 111:110342

Article  PubMed  Google Scholar 

El Ouaamari Y, Van den Bos J, Willekens B, Cools N, Wens I (2023) Neurotrophic factors as regenerative therapy for neurodegenerative Diseases: current status, challenges and Future perspectives. Int J Mol Sci 24(4):3866

Article  PubMed  PubMed Central  Google Scholar 

Lang UE, Hellweg R, Seifert F, Schubert F, Gallinat J (2007) Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity. Biol Psychiatry 62(5):530–535

Article  CAS  PubMed  Google Scholar 

Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, Alexander T et al (2008) Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol 21(3):166–170

Article  PubMed  Google Scholar 

Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Gabriela Nielsen M, Placentino A et al (2010) Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 11(6):763–773

Article  PubMed  Google Scholar 

Castrén E, Rantamäki T (2010) The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev Neurobiol 70(5):289–297

Article  PubMed  Google Scholar 

Nishino S, Ohtomo K, Numata Y, Sato T, Nakahata N, Kurita M (2012) Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations. Prog Neuropsychopharmacol Biol Psychiatry 39(1):17–22

Article  CAS  PubMed  Google Scholar 

Huang T-L, Hung Y-Y (2009) Lorazepam reduces the serum brain-derived neurotrophic factor level in schizophrenia patients with catatonia. Prog Neuropsychopharmacol Biol Psychiatry 33(1):158–159

Article  CAS  PubMed  Google Scholar 

Jornada LK, Moretti M, Valvassori SS, Ferreira CL, Padilha PT, Arent CO et al (2010) Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain. J Psychiatr Res 44(8):506–510

Article  PubMed  Google Scholar 

Matrisciano F, Bonaccorso S, Ricciardi A, Scaccianoce S, Panaccione I, Wang L et al (2009) Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. J Psychiatr Res 43(3):247–254

Article  PubMed  Google Scholar 

Ibrahim AM, Chauhan L, Bhardwaj A, Sharma A, Fayaz F, Kumar B et al (2022) Brain-derived neurotropic factor in neurodegenerative disorders. Biomedicines 10(5):1143

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreska T, Rauskolb S, Schukraft N, Lüningschrör P, Sasi M, Signoret-Genest J et al (2020) Induction of BDNF expression in layer II/III and layer V neurons of the motor cortex is essential for motor learning. J Neurosci 40(33):6289–6308

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Deus JL, Amorim MR, Ribeiro AB, Barcellos-Filho PC, Ceballos CC, Branco LGS et al (2021) Loss of brain-derived neurotrophic factor mediates inhibition of hippocampal long-term potentiation by high-intensity sound. Cell Mol Neurobiol 41:751–763

Article  PubMed  Google Scholar 

Del Angel YC, Orfila JE, Herson PS, Brooks-Kayal A, González MI (2021) Down-regulation of AMPA receptors and long-term potentiation during early epileptogenesis. Epilepsy Behav 124:108320

Article  Google Scholar 

Anderson WW (2020) Epileptogenesis. Cortical Plasticity: Garland Science; p. 149 – 89

Walczak A, Szczepankiewicz AA, Ruszczycki B, Magalska A, Zamlynska K, Dzwonek J et al (2013) Novel higher-order epigenetic regulation of the Bdnf gene upon seizures. J Neurosci 33(6):2507–2511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geyer PK, Vitalini MW, Wallrath LL (2011) Nuclear organization: taking a position on gene expression. Curr Opin Cell Biol 23(3):354–359

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bandeira IC, Giombelli L, Werlang IC, Abujamra AL, Secchi TL, Brondani R et al (2021) Methylation of BDNF and SLC6A4 gene promoters in Brazilian patients with temporal lobe Epilepsy presenting or not psychiatric comorbidities. Front Integr Neurosci 15:764742

Article  CAS