One Small Step (Down) for Antibiotics, One Giant Leap for Outpatient Therapy: The Role of Oral Antibiotics in Serious Bacterial Infections

Underwood J, Marks M, Collins S, Logan S, Pollara G. Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy. J Antimicrob Chemother. 2019;74:787–90. https://doi.org/10.1093/jac/dky474.

Article  CAS  PubMed  Google Scholar 

Kaul CM, Haller M, Yang J, Solomon S, Wang Yaojie, Wu Rong, et al. Assessment of risk factors associated with outpatient parenteral antimicrobial therapy (OPAT) complications: a retrospective cohort study. Antimicrob Steward Healthc Epidemiol. 2022;2:e183. https://doi.org/10.1017/ash.2022.313.

Browning S, Loewenthal MR, Freelander I, Dobson PM, Schneider K, Davis JS. Safety of prolonged outpatient courses of intravenous antibiotics: a prospective cohort study. Clin Microbiol Infect. 2022;28:832–7. https://doi.org/10.1016/j.cmi.2021.12.020.

Article  CAS  PubMed  Google Scholar 

Krah NM, Bardsley T, Nelson R, Esquibel L, Crosby M, Byington CL, et al. Economic burden of home antimicrobial therapy: OPAT versus oral therapy. Hosp Pediatr. 2019;9:234–40. https://doi.org/10.1542/hpeds.2018-0193.

Article  PubMed  PubMed Central  Google Scholar 

Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, Rybak MJ, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132:1435–86. https://doi.org/10.1161/CIR.0000000000000296.

Article  CAS  PubMed  Google Scholar 

Dworkin RJ, Lee BL, Sande MA, Chambers HF. Treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin. Lancet. 1989;2:1071–3. https://doi.org/10.1016/S0140-6736(89)91083-0.

Article  CAS  PubMed  Google Scholar 

Stamboulian D, Bonvehi P, Arevalo C, Bologna R, Cassetti I, Scilingo V, et al. Antibiotic management of outpatients with endocarditis due to penicillin-susceptible streptococci. Rev Infect Dis. 1991;13:S160–3. https://doi.org/10.1093/clinids/13.supplement_2.s160.

Article  PubMed  Google Scholar 

Demonchy E, Dellamonica P, Roger PM, Bernard E, Cua E, Pulcini C. Audit of antibiotic therapy used in 66 cases of endocarditis. Med Mal Infect. 2011;41:602–7. https://doi.org/10.1016/j.medmal.2011.08.003.

Article  CAS  PubMed  Google Scholar 

Mzabi A, Kernéis S, Richaud C, Podglajen I, Fernandez-Gerlinger MP, Mainardi JL. Switch to oral antibiotics in the treatment of infective endocarditis is not associated with increased risk of mortality in non-severely ill patients. Clin Microbiol Infect. 2016;22:607–12. https://doi.org/10.1016/j.cmi.2016.04.003.

Article  CAS  PubMed  Google Scholar 

Tissot-Dupont H, Gouriet F, Oliver L, Jamme M, Casalta JP, Jimeno MT, et al. High-dose trimethoprim-sulfamethoxazole and clindamycin for Staphylococcus aureus endocarditis. Int J Antimicrob Agents. 2019;54:143–8. https://doi.org/10.1016/j.ijantimicag.2019.06.006.

Article  CAS  PubMed  Google Scholar 

•• Iversen K, Ihlemann N, Gill SU, Madsen T, Elming H, Jensen KT, et al. Partial oral versus intravenous antibiotic treatment of endocarditis. N Engl J Med. 2019;380:415–24. https://doi.org/10.1056/NEJMoa1808312. First randomized, controlled trial of PO stepdown therapy for endocarditis.

Article  CAS  PubMed  Google Scholar 

Pries-Heje MM, Wiingaard C, Ihlemann N, Gill SU, Bruun NE, Elming H, et al. Five-year outcomes of the partial oral treatment of endocarditis (POET) trial. N Engl J Med. 2022;386:601–2. https://doi.org/10.1056/NEJMc2114046.

Article  PubMed  Google Scholar 

Freling S, Wald-Dickler N, Banerjee J, Canamar CP, Tangpraphaphorn S, Bruce D, et al. Real-world application of oral therapy for infective endocarditis: a multicenter retrospective, cohort study. Clin Infect Dis. 2023;ciad119. https://doi.org/10.1093/cid/ciad119.

• McDonald EG, Aggrey G, Tarik Aslan A, Casias M, Cortes-Penfield N, Dong MQ, et al. Guidelines for diagnosis and management of infective endocarditis in adults: a WikiGuidelines group consensus statement. JAMA Netw Open. 2023;6: e2326366. https://doi.org/10.1001/jamanetworkopen.2023.26366. Consensus guidelines supporting oral therapy for endocarditis.

Article  PubMed  Google Scholar 

Wikiguidelines charter. Accessed October 10, 2023. https://wikiguidelines.com/charter.

Lipsky BA, Berendt AR, Cornia PB, Pile JC, Peters EJG, Armstrong DG, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132–73. https://doi.org/10.1093/cid/cis346.

Article  PubMed  Google Scholar 

Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:e1-25. https://doi.org/10.1093/cid/cis803.

Article  PubMed  Google Scholar 

Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, et al. 2015 Infectious Diseases Society of America (IDSA) clinical practice guideline for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis. 2015;61:e26-46. https://doi.org/10.1093/cid/civ482.

Article  PubMed  Google Scholar 

•• Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019;380:425–36. https://doi.org/10.1056/NEJMoa1710926. First randomized, controlled trial of PO stepdown therapy for bone and joint infections.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azamgarhi T, Shah A, Warren S. Clinical experience of implementing oral versus intravenous antibiotics (OVIVA) in a specialist orthopedic hospital. Clin Infect Dis. 2021;73:e2582–8. https://doi.org/10.1093/cid/ciaa985.

Article  CAS  PubMed  Google Scholar 

• Spellberg B, Aggrey G, Brennan MB, Footer B, Forrest G, Hamilton F, et al. Use of novel strategies to develop guidelines for management of pyogenic osteomyelitis in adults: a WikiGuidelines group consensus statement. JAMA Netw Open. 2022;5: e2211321. https://doi.org/10.1001/jamanetworkopen.2022.11321. Consensus guidelines supporting oral therapy for osteomyelitis.

Article  PubMed  PubMed Central  Google Scholar 

Schrenzel J, Harbarth S, Schockmel G, Genné D, Bregenzer T, Flueckiger U, et al. A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection. Clin Infect Dis. 2004;39:1285–92. https://doi.org/10.1086/424506.

Article  CAS  PubMed  Google Scholar 

Wilcox M, Nathwani D, Dryden M. Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infections. J Antimicrob Chemother. 2004;53:335–44. https://doi.org/10.1093/jac/dkh088.

Article  CAS  PubMed  Google Scholar 

Wilcox MH, Tack KJ, Bouza E, Herr DL, Ruf BR, Ijzerman MM, et al. Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study. Clin Infect Dis. 2009;48:203–12. https://doi.org/10.1086/595686.

Article  CAS  PubMed  Google Scholar 

Paul M, Bishara J, Yahav D, Goldberg E, Neuberger A, Ghanem-Zoubi N, et al. Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial. BMJ. 2015;350: h2219. https://doi.org/10.1136/bmj.h2219.

Article  PubMed  PubMed Central  Google Scholar 

Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52:e18-55. https://doi.org/10.1093/cid/ciq146.

Article  PubMed  Google Scholar 

Willekens R, Puig-Asensio M, Ruiz-Camps I, Larrosa MN, González-López JJ, Rodríguez-Pardo D, et al. Early oral switch to linezolid for low-risk patients with Staphylococcus aureus bloodstream infections: a propensity-matched cohort study. Clin Infect Dis. 2019;69:381–7. https://doi.org/10.1093/cid/ciy916.

Article  CAS  PubMed  Google Scholar 

Bupha-Intr O, Blackmore T, Bloomfield M. Efficacy of early oral switch with β-Lactams for low-risk Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2020;64:e02345-e2419. https://doi.org/10.1128/AAC.02345-19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mun SJ, Kim SH, Huh K, Cho SY, Kang CI, Chung DR, et al. Oral step-down therapy in patients with uncomplicated Staphylococcus aureus primary bacteremia and catheter-related bloodstream infections. J Chemother. 2022;34:319–25. https://doi.org/10.1080/1120009X.2022.2031469.

Article  CAS  PubMed  Google Scholar 

Diego-Yagüe I, Mora-Vargas A, Vázquez-Comendador JM, Santamarina-Alcantud B, Fernández-Cruz A, Múñez-Rubio E, et al. Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis. Clin Microbiol Infect. 2023;29:744–50. https://doi.org/10.1016/j.cmi.2023.02.001.

Article  CAS  PubMed  Google Scholar 

• Kaasch AJ, López-Cortés LE, Rodríguez-Baño J, Cisneros JM, Navarro MD, Fätkenheuer G, et al. Early oral switch in low-risk Staphylococcus aureus bloodstream infection. medRxiv. 2023. https://doi.org/10.1101/2023.07.03.23291932. Preprint article describing the results of the SABATO trial supporting oral therapy for the treatment of uncomplicated Staphylococcal bacteremia.

Hospenthal DR, Waters CD, Beekmann SE, Polgreen PM. Practice patterns of infectious diseases physicians in transitioning from intravenous to oral therapy in patients with bacteremia. Open Forum Infect Dis. 2020;7:ofz386. https://doi.org/10.1093/ofid/ofz386.

Kang A, Beuttler R, Minejima E. Evaluation of step-down oral antibiotic therapy for uncomplicated streptococcal bloodstream infections on clinical outcomes. Ther Adv Infect Dis. 2022;9:20499361211073250. https://doi.org/10.1177/20499361211073248.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramos-Otero GP, Sarangarm P, et al. A retrospective analysis of intravenous vs oral antibiotic step-down therapy for the treatment of uncomplicated streptococcal bloodstream infections. J Clin Phamacol. 2022;62:1372–8. https://doi.org/10.1002/jcph.2097.

Article  CAS  Google Scholar 

Waked R, Craig WY, Mercuro NJ, Wungwattana M, Wood E, Rokas KE. Uncomplicated streptococcal bacteremia: the era of oral antibiotic step-down therapy? Int J Antimicrob Agents. 2023;61: 106736. https://doi.org/10.1016/j.ijantimicag.2023.106736.

Article  CAS  PubMed  Google Scholar 

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