Abi Rached L, McDermott MF, Pontarotti P (1999) The MHC big bang. Immunol Rev 167:33–44

Article  CAS  PubMed  Google Scholar 

Abi-Rached L, Gilles A, Shiina T, Pontarotti P, Inoko H (2002) Evidence of en bloc duplication in vertebrate genomes. Nat Genet 31:100–105

Article  CAS  PubMed  Google Scholar 

Adachi K, Toyota M, Sasaki Y, Yamashita T, Ishida S, Ohe-Toyota M, Maruyama R, Hinoda Y, Saito T, Imai K, Kudo R, Tokino T (2004) Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene 23:7791–7798

Article  CAS  PubMed  Google Scholar 

Agrawal A, Eastman QM, Schatz DG (1998) Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394:744–751

Article  CAS  PubMed  Google Scholar 

Bernstein RM, Schluter SF, Bernstein H, Marchalonis JJ (1996) Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases. Proc Natl Acad Sci USA 93:9454–9459

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boehm T, McCurley N, Sutoh Y, Schorpp M, Kasahara M, Cooper MD (2012) VLR-based adaptive immunity. Annu Rev Immunol 30:203–220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouza AA, Isom LL (2018) Voltage-gated sodium channel beta subunits and their related diseases. Handb Exp Pharmacol 246:423–450

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brandt CS, Baratin M, Yi EC, Kennedy J, Gao Z, Fox B, Haldeman B, Ostrander CD, Kaifu T, Chabannon C, Moretta A, West R, Xu W, Vivier E, Levin SD (2009) The B7 family member B7–H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med 206:1495–1503

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carmona LM, Schatz DG (2017) New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination. FEBS J 284:1590–1605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen R, Zhang L, Qi J, Zhang N, Zhang L, Yao S, Wu Y, Jiang B, Wang Z, Yuan H, Zhang Q, Xia C (2018) Discovery and analysis of invertebrate IgVJ-C2 structure from amphioxus provides insight into the evolution of the Ig superfamily. J Immunol 200:2869–2881

Article  CAS  PubMed  Google Scholar 

Chioni AM, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB (2009) A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. Int J Biochem Cell Biol 41:1216–1227

Article  CAS  PubMed  Google Scholar 

Chothia C, Novotny J, Bruccoleri R, Karplus M (1985) Domain association in immunoglobulin molecules. The packing of variable domains. J Mol Biol 186:651–663

Article  CAS  PubMed  Google Scholar 

Chrétien I, Marcuz A, Courtet M, Katevuo K, Vainio O, Heath JK, White SJ, Du PL (1998) CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. Eur J Immunol 28:4094–4104

Article  PubMed  Google Scholar 

Collette Y, Gilles A, Pontarotti P, Olive D (2003) A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol 24:387–394

Article  CAS  PubMed  Google Scholar 

Danchin EG, Pontarotti P (2004) Towards the reconstruction of the bilaterian ancestral pre-MHC region. Trends Genet 20:587–591

Article  CAS  PubMed  Google Scholar 

Dornburg A, Yoder JA (2022) On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity. Immunogenetics 74:111–128

Article  CAS  PubMed  Google Scholar 

Du Pasquier L (2004a) Innate immunity in early chordates and the appearance of adaptive immunity. C R Biol 327:591–601

Article  PubMed  Google Scholar 

Du Pasquier L (2004b) Speculations on the origin of the vertebrate immune system. Immunol Lett 92:3–9

Article  PubMed  Google Scholar 

Du Pasquier L, Chrétien I (1996) Why is CTX all the RAGE? Res. Immunol 147:261–266

Google Scholar 

Du Pasquier L, Zucchetti I, De Santis R (2004) Immunoglobulin superfamily receptors in protochordates: before RAG time. Immunol Rev 198:233–248

Article  PubMed  Google Scholar 

Felsenstein J (1985) Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783–791

Article  PubMed  Google Scholar 

Flajnik MF (2014) Re-evaluation of the immunological Big Bang. Curr Biol 24:R1060–R1065

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flajnik MF (2018) A cold-blooded view of adaptive immunity. Nat Rev Immunol 18:438–453

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flajnik MF, Kasahara M (2010) Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat Rev Genet 11:47–59

Article  CAS  PubMed  Google Scholar 

Flajnik MF, Tlapakova T, Criscitiello MF, Krylov V, Ohta Y (2012) Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7’s historical relationship with the MHC. Immunogenetics 64:571–590

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flaswinkel H, Barner M, Reth M (1995) The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains. Semin Immunol 7:21–27

Article  CAS  PubMed  Google Scholar 

Fu Y, Yang Z, Huang J, Cheng X, Wang X, Yang S, Ren L, Lian Z, Han H, Zhao Y (2019) Identification of two nonrearranging IgSF genes in chicken reveals a novel family of putative remnants of an antigen receptor precursor. J Immunol 202:1992–2004

Article  CAS  PubMed  Google Scholar 

Hayashi M, Ishibashi T, Tanaka K, Kasahara M (1997) The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter. J Immunol 159:2760–2770

Article  CAS  PubMed  Google Scholar 

Hsu E, Pulham N, Rumfelt LL, Flajnik MF (2006) The plasticity of immunoglobulin gene systems in evolution. Immunol Rev 210:8–26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hudspeth K, Silva-Santos B, Mavilio D (2013) Natural cytotoxicity receptors: broader expression patterns and functions in innate and adaptive immune cells. Front Immunol 4:69

Article  PubMed  PubMed Central  Google Scholar 

Isom LL (2001) Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7:42–54

Article  CAS  PubMed  Google Scholar 

Jones DT, Taylor WR, Thornton JM (1992) The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci 8:275–282

CAS  PubMed  Google Scholar 

Joyce MG, Tran P, Zhuravleva MA, Jaw J, Colonna M, Sun PD (2011) Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. Proc Natl Acad Sci USA 108:6223–6228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasahara M (1997) New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system. Hereditas 127:59–65

Article  CAS  PubMed  Google Scholar 

Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, Ishibashi T (1996) Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci USA 93:9096–9101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasahara M, Suzuki T, Pasquier LD (2004) On the origins of the adaptive immune system: novel insights from invertebrates and cold-blooded vertebrates. Trends Immunol 25:105–111

Article  CAS  PubMed  Google Scholar 

King RJ, Singh PK, Mehla K (2022) The cholesterol pathway: impact on immunity and cancer. Trends Immunol 43:78–92

Article  CAS