To investigate analgesic effect of ALCOCK tube ultrasound-guided internal pudendal nerve block during anus surgery, the patients conforming the inclusion criteria were classified into mixed hemorrhoid, anal fistula, and anal fissure and randomly divided into the control group and the experimental group. Both groups underwent corresponding surgical treatment. At the end of surgery, bilateral pudendal nerve block was performed on experimental group. The preoperative data (age, gender, and diagnosis), duration of surgery, blood loss, first postoperative pain time as well as scores, pain scores 4h, 8h, 12h, 24h, 48h, and 72h after surgery, complications, and satisfaction of patients in two groups were analyzed. Duration of surgery of all patients in experimental group was remarkably higher than that in control group (P<0.05). Blood loss in anal fistula experimental group was higher than that in control group (P<0.05). First pain time in anal fistula experimental group was all apparently higher than that in control group (P<0.05), while first pain scores were all lower than those in control group (P<0.05). Postoperative follow-up showed that pain scores of anal fistula and fissure groups 48 hours after surgery were different. The total incidence of adverse reactions of all experimental groups was lower than that of control group (P<0.05), while patient satisfaction was all higher than that in control group (P<0.05). ALCOCK tube ultrasound-guided internal pudendal nerve blocker had good analgesic effect during anus surgery with high patient satisfaction. It was worthy of promotion and use.