Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89–95. https://doi.org/10.1067/mcp.2001.113989.
Loder E, Rizzoli P. Biomarkers in migraine: their promise, problems, and practical applications. Headache. 2006;46(7):1046–58. https://doi.org/10.1111/j.1526-4610.2006.00498.x.
Phillips KA, Van Bebber S, Issa AM. Diagnostics and biomarker development: priming the pipeline. Nat Rev Drug Discov. 2006;5(6):463–9. https://doi.org/10.1038/nrd2033.
Article CAS PubMed Google Scholar
Durham P, Papapetropoulos S. Biomarkers associated with migraine and their potential role in migraine management. Headache. 2013;53(8):1262–77. https://doi.org/10.1111/head.12174.
Headache Classification Committee of the International Headache Society (IHS) The international classification of headache disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. https://doi.org/10.1177/0333102417738202.
Lipton RB, Chu MK. Conceptualizing the relationship between chronic migraine and episodic migraine. Expert Rev Neurother. 2009;9(10):1451–4. https://doi.org/10.1002/pmic.200800454.
Article CAS PubMed Google Scholar
Benatto MT, Florencio LL, Carvalho GF, Dach F, Bigal ME, Chaves TC, et al. Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease. Arq Neuropsiquiatr. 2017;75(3):153–9. https://doi.org/10.1590/0004-282x20170015.
van Dongen RM, Zielman R, Noga M, Dekkers OM, Hankemeier T, van den Maagdenberg AM, et al. Migraine biomarkers in cerebrospinal fluid: a systematic review and meta-analysis. Cephalalgia. 2017;37(1):49–63. https://doi.org/10.1177/0333102415625614.
Angioni D, Delrieu J, Hansson O, Fillit H, Aisen P, Cummings J, et al. Blood biomarkers from research use to clinical practice: what must be done? A Report from the EU/US CTAD Task Force. J Prev Alzheimers Dis. 2022;9(4):569–79. https://doi.org/10.14283/jpad.2022.85.
Article CAS PubMed PubMed Central Google Scholar
Russell FA, King R, Smillie SJ, Kodji X, Brain SD. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014;94(4):1099–142. https://doi.org/10.1152/physrev.00034.2013.
Article CAS PubMed PubMed Central Google Scholar
Dos Santos JBR, da Silva MRR. Small molecule CGRP receptor antagonists for the preventive treatment of migraine: a review. Eur J Pharmacol. 2022;922:174902. https://doi.org/10.1016/j.ejphar.2022.174902.
Vandervorst F, Van Deun L, Van Dycke A, Paemeleire K, Reuter U, Schoenen J, et al. CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs. J Headache Pain. 2021;22(1):128. https://doi.org/10.1186/s10194-021-01335-2.
Article CAS PubMed PubMed Central Google Scholar
Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993;33(1):48–56. https://doi.org/10.1002/ana.410330109.
Article CAS PubMed Google Scholar
Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28(2):183–7. https://doi.org/10.1002/ana.410280213.
Article CAS PubMed Google Scholar
Sarchielli P, Alberti A, Codini M, Floridi A, Gallai V. Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks. Cephalalgia. 2000;20(10):907–18. https://doi.org/10.1046/j.1468-2982.2000.00146.x.
Article CAS PubMed Google Scholar
Sarchielli P, Pini LA, Zanchin G, Alberti A, Maggioni F, Rossi C, et al. Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. Cephalalgia. 2006;26(3):257–65. https://doi.org/10.1111/j.1468-2982.2005.01016.x.
Article CAS PubMed Google Scholar
Fusayasu E, Kowa H, Takeshima T, Nakaso K, Nakashima K. Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. Pain. 2007;128(3):209–14. https://doi.org/10.1016/j.pain.2006.09.017.
Article CAS PubMed Google Scholar
Ashina M, Bendtsen L, Jensen R, Schifter S, Olesen J. Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks. Pain. 2000;86(1–2):133–8. https://doi.org/10.1016/s0304-3959(00)00232-3.
Article CAS PubMed Google Scholar
Ashina M, Hansen JM, BO ÁD, Olesen J. Human models of migraine - short-term pain for long-term gain. Nat Rev Neurol. 2017;13(12):713–24. https://doi.org/10.1038/nrneurol.2017.137.
Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics Pain. 1989;38(1):17–24. https://doi.org/10.1016/0304-3959(89)90067-5.
Article CAS PubMed Google Scholar
Gallai V, Sarchielli P, Floridi A, Franceschini M, Codini M, Glioti G, et al. Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. Cephalalgia. 1995;15(5):384–90. https://doi.org/10.1046/j.1468-2982.1995.1505384.x.
Article CAS PubMed Google Scholar
Juhasz G, Zsombok T, Modos EA, Olajos S, Jakab B, Nemeth J, et al. NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. Pain. 2003;106(3):461–70. https://doi.org/10.1016/j.pain.2003.09.008.
Article CAS PubMed Google Scholar
Tvedskov JF, Lipka K, Ashina M, Iversen HK, Schifter S, Olesen J. No increase of calcitonin gene-related peptide in jugular blood during migraine. Ann Neurol. 2005;58(4):561–8. https://doi.org/10.1002/ana.20605.
Article CAS PubMed Google Scholar
Alpuente A, Gallardo VJ, Asskour L, Caronna E, Torres-Ferrus M, Pozo-Rosich P. Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks. Cephalalgia. 2022;42(3):186–96. https://doi.org/10.1177/03331024211040467.
Rodríguez-Osorio X, Sobrino T, Brea D, Martínez F, Castillo J, Leira R. Endothelial progenitor cells: a new key for endothelial dysfunction in migraine. Neurology. 2012;79(5):474–9. https://doi.org/10.1212/WNL.0b013e31826170ce.
Nicolodi M, Del Bianco E. Sensory neuropeptides (substance P, calcitonin gene-related peptide) and vasoactive intestinal polypeptide in human saliva: their pattern in migraine and cluster headache. Cephalalgia. 1990;10(1):39–50. https://doi.org/10.1046/j.1468-2982.1990.1001039.x.
Article CAS PubMed Google Scholar
Bellamy JL, Cady RK, Durham PL. Salivary levels of CGRP and VIP in rhinosinusitis and migraine patients. Headache. 2006;46(1):24–33. https://doi.org/10.1111/j.1526-4610.2006.00294.x.
• Kamm K, Straube A, Ruscheweyh R. Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls. Cephalalgia. 2019;39(12):1535–43. https://doi.org/10.1177/0333102419856640. An important study on the potential of blood CGRP levels as a marker of treatment effectiveness.
Cernuda-Morollón E, Martínez-Camblor P, Ramón C, Larrosa D, Serrano-Pertierra E, Pascual J. CGRP and VIP levels as predictors of efficacy of onabotulinumtoxin type A in chronic migraine. Headache. 2014;54(6):987–95. https://doi.org/10.1111/head.12372.
•• Gárate G, González-Quintanilla V, González A, Pascual M, Pérez-Pereda S, Madera J, et al. Serum alpha and beta-CGRP levels in chronic migraine patients before and after monoclonal antibodies against CGRP or its receptor. Ann Neurol. 2023. https://doi.org/10.1002/ana.26658. An article on the use of blood CGRP levels as a marker of therapeutic response to treatment.
de Vries LS, Garrelds IM, Danser AHJ, Terwindt GM, MaassenVanDenBrink A. Serum CGRP in migraine patients using erenumab as preventive treatment. J Headache Pain. 2022;23(1):120. https://doi.org/10.1186/s10194-022-01483-z.
Juhasz G, Zsombok T, Jakab B, Nemeth J, Szolcsanyi J, Bagdy G. Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack. Cephalalgia. 2005;25(3):179–83. https://doi.org/10.1111/j.1468-2982.2005.00836.x.
Article CAS PubMed Google Scholar
Nitecka-Buchta A, Marek B, Kapustecka JB, Baron S. Venopunction of the cubital vein as an alternative approach for CGRP plasma level evaluation in tmd patients. Endokrynol Pol. 2017;68(3):326–33. https://doi.org/10.5603/ep.2017.0025.
Article CAS PubMed Google Scholar
Messlinger K, Vogler B, Kuhn A, Sertel-Nakajima J, Frank F, Broessner G. CGRP measurements in human plasma - a methodological study. Cephalalgia. 2021;41(13):1359–73. https://doi.org/10.1177/03331024211024161.
Article PubMed PubMed Central Google Scholar
Vikelis M, Mitsikostas DD. The role of glutamate and its receptors in migraine. CNS Neurol Disord Drug Targets. 2007;6(4):251–7. https://doi.org/10.2174/187152707781387279.
Article CAS PubMed Google Scholar
Ferrari MD, Odink J, Bos KD, Malessy MJ, Bruyn GW. Neuroexcitatory plasma amino acids are elevated in migraine. Neurology. 1990;40(10):1582–6. https://doi.org/10.1212/wnl.40.10.1582.
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