Basal forebrain functional connectivity as a mediator of associations between cardiorespiratory fitness and cognition in healthy older women

Ahmad, F. B., & Anderson, R. N. (2021). The leading causes of death in the US for 2020. JAMA, 325(18), 1829–1830.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Astrand, P. O., & Ryhming, I. (1954). A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during submaximal work. Journal of Applied Physiology, 7(2), 218–21.

Article  CAS  PubMed  Google Scholar 

Barha, C. K., & Liu-Ambrose, T. (2018). Exercise and the aging brain: Considerations for sex differences. Brain Plast., 4(1), 53–63.

Article  PubMed  PubMed Central  Google Scholar 

Barha, C. K., Hsiung, G. Y. R., Best, J. R., Davis, J. C., Eng, J. J., Jacova, C., et al. (2017a). Sex difference in aerobic exercise efficacy to improve cognition in older adults with vascular cognitive impairment: Secondary analysis of a randomized controlled trial. Journal of Alzheimer’s Disease, 60(4), 1397–410.

Article  CAS  PubMed  Google Scholar 

Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017b). Sex differences in exercise efficacy to improve cognition: A systematic review and meta-analysis of randomized controlled trials in older humans. Frontiers in Neuroendocrinology, 46, 71–85.

Article  PubMed  Google Scholar 

Barha, C. K., Hsu, C. L., Ten Brinke, L., & Liu-Ambrose, T. (2019). Biological sex: A potential moderator of physical activity efficacy on brain health. Front Aging Neurosci., 11, 329.

Article  PubMed  PubMed Central  Google Scholar 

Barha, C. K., Best, J. R., Rosano, C., Yaffe, K., Catov, J. M., & Liu-Ambrose, T. (2020). Sex-specific relationship between long-term maintenance of physical activity and cognition in the health ABC study: Potential role of hippocampal and dorsolateral prefrontal cortex volume. The Journals of Gerontology: Series A, 75(4), 764–70.

Article  CAS  Google Scholar 

Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173.

Article  CAS  PubMed  Google Scholar 

Barth, C., Villringer, A., & Sacher, J. (2015). Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Frontiers in Neuroscience, 9, 37.

Article  PubMed  PubMed Central  Google Scholar 

Basso, J. C., & Suzuki, W. A. (2017). The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: A review. Brain Plasticity, 2(2), 127–52.

Article  PubMed  PubMed Central  Google Scholar 

Beall, E. B., & Lowe, M. J. (2014). SimPACE: Generating simulated motion corrupted BOLD data with synthetic-navigated acquisition for the development and evaluation of SLOMOCO: A new, highly effective slicewise motion correction. NeuroImage, 101, 21–34.

Article  PubMed  Google Scholar 

Boss, L., Kang, D. H., Bergstrom, N., & Leasure, J. L. (2015). Endogenous sex hormones and cognitive function in the elderly. Aging Clinical and Experimental Research, 27(4), 515–21.

Article  PubMed  Google Scholar 

Burdette, J. H., Laurienti, P. J., Espeland, M. A., Morgan, A. R., Telesford, Q., Vechlekar, C. D., et al. (2010). Using network science to evaluate exercise-associated brain changes in older adults. Frontiers in Aging Neuroscience, 2, 23.

PubMed  PubMed Central  Google Scholar 

Buzsaki, G. Y., Bickford, R. G., Ponomareff, G., Thal, L. J., Mandel, R., & Gage, F. H. (1988). Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. Journal of Neuroscience, 8(11), 4007–26.

Article  CAS  PubMed  Google Scholar 

Chen, F. T., Erickson, K. I., Huang, H., & Chang, Y. K. (2020). The association between physical fitness parameters and white matter microstructure in older adults: A diffusion tensor imaging study. Psychophysiology, 57(5), e13539.

Article  PubMed  Google Scholar 

Chiang-shan, R. L., Ide, J. S., Zhang, S., Hu, S., Chao, H. H., & Zaborszky, L. (2014). Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age. NeuroImage, 97, 321–32.

Article  Google Scholar 

Chiesa, P. A., Cavedo, E., Grothe, M. J., Houot, M., Teipel, S. J., Potier, M. C., et al. (2019). Relationship between basal forebrain resting-state functional connectivity and brain amyloid-β deposition in cognitively intact older adults with subjective memory complaints. Radiology, 290(1), 167–76.

Article  PubMed  Google Scholar 

Chirles, T. J., Reiter, K., Weiss, L. R., Alfini, A. J., Nielson, K. A., & Smith, J. C. (2017). Exercise training and functional connectivity changes in mild cognitive impairment and healthy elders. Journal of Alzheimer’s Disease, 57(3), 845–56.

Article  PubMed  Google Scholar 

Chu, C. H., Yang, K. T., Song, T. F., Liu, J. H., Hung, T. M., & Chang, Y. K. (2016). Cardiorespiratory fitness is associated with executive control in late-middle-aged adults: An event-related (De) synchronization (ERD/ERS) study. Frontiers in Psychology, 7, 1135.

Article  PubMed  PubMed Central  Google Scholar 

Chudasama, Y., Dalley, J. W., Nathwani, F., Bouger, P., & Robbins, T. W. (2004). Cholinergic modulation of visual attention and working memory: Dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine. Learning & Memory, 11(1), 78–86.

Article  Google Scholar 

Colcombe, S., & Kramer, A. F. (2003). Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychological Science, 14(2), 125–30.

Article  PubMed  Google Scholar 

Counts, S. E., Che, S., Ginsberg, S. D., & Mufson, E. J. (2011). Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer’s disease. Journal of Chemical Neuroanatomy, 42(2), 111–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cox, R. W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers and Biomedical Research, 29(3), 162–73.

Article  CAS  PubMed  Google Scholar 

Cullinane, E. M., Siconolfi, S., Carleton, R. A., & Thompson, P. D. (1988). Modification of the Astrand-Rhyming sub-maximal bicycle test for estimating VO2max of inactive men and women. Medicine and Science in Sports and Exercise, 20(3), 317–8.

CAS  PubMed  Google Scholar 

Delis, D. C., Kramer, J. H., Kaplan, E., & Holdnack, J. (2004). Reliability and validity of the Delis-Kaplan Executive Function System: An update. Journal of the International Neuropsychological Society, 10(2), 301.

Article  PubMed  Google Scholar 

Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive function system. Odessa, FL: Psychological Assessment Resources.

Dupuy, O., Gauthier, C. J., Fraser, S. A., Desjardins-Crèpeau, L., Desjardins, M., Mekary, S., et al. (2015). Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. Frontiers in Human Neuroscience, 9, 66.

Article  PubMed  PubMed Central  Google Scholar 

Erickson, K. I., Colcombe, S. J., Elavsky, S., McAuley, E., Korol, D. L., Scalf, P. E., et al. (2007). Interactive effects of fitness and hormone treatment on brain health in postmenopausal women. Neurobiology of Aging, 28(2), 179–85.

Article  CAS  PubMed  Google Scholar 

Ferreira-Vieira, T. H., Guimaraes, I. M., Silva, F. R., & Ribeiro, F. M. (2016). Alzheimer’s disease: targeting the cholinergic system. Current Neuropharmacology, 14(1), 101–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., et al. (2018). Sex differences in Alzheimer disease—the gateway to precision medicine. Nature Reviews. Neurology, 14(8), 457–69.

Article  PubMed  Google Scholar 

Fischl, B. (2012). FreeSurfer. Neuroimage., 62(2), 774–81.

Article  PubMed  Google Scholar 

Garibotto, V., Tettamanti, M., Marcone, A., Florea, I., Panzacchi, A., Moresco, R., et al. (2013). Cholinergic activity correlates with reserve proxies in Alzheimer’s disease. Neurobiology of Aging, 34(11), 2694-e13.

Article  Google Scholar 

Grothe, M., Heinsen, H., & Teipel, S. J. (2012). Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer’s disease. Biological Psychiatry, 71(9), 805–813.

Article  CAS  PubMed  Google Scholar 

Gur, R. C., Gunning-Dixon, F., Bilker, W. B., & Gur, R. E. (2002). Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cerebral Cortex, 12(9), 998–1003.

Article  PubMed  Google Scholar 

Hall, J. M., & Savage, L. M. (2016). Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior. Experimental Neurology, 278, 62–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayes, A. F. (2012). PROCESS: A versatile computational tool for observed variable mediation, moderation, and conditional process modeling. University of Kansas.

Google Scholar 

Hayes, S. M., Forman, D. E., & Verfaellie, M. (2016). Cardiorespiratory fitness is associated with cognitive performance in older but not younger adults. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 71(3), 474–82.

Article  PubMed  Google Scholar 

Henny, P., & Jones, B. E. (2008). Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons. European Journal of Neuroscience, 27(3), 654–70.

Article  PubMed  Google Scholar 

Horstman, A. M., Dillon, E. L., Urban, R. J., & Sheffield-Moore, M. (2012). The role of androgens and estrogens on healthy aging and longevity. The Journals of Gerontology. Series A, Biomedical Sciences and Medical Science, 67(11), 1140–52.

留言 (0)

沒有登入
gif