Comprehensive microbiomes and fecal metabolomics combined with network pharmacology reveal the effects of Jichuanjian on aged functional constipation

AbbreviationsAFC

aged functional constipation

GAS

gastrogut transport time

LDA

linear discriminant analysis

LEfSe

linear discriminant analysis effect size

OPLS-DA

orthogonal partial least-squares discriminant analysis

PC

positive control (i.e. mosapride)

PCA

principal component analysis

PLS-DA

partial least square-discrimination analysis

PPI

protein-protein interaction

RFA

rotary fatigue apparatus

SMA

small gut propulsion rate

Keywords

Aged functional constipation

Jichuanjian

Metabolomics

Microbiomes

“Behaviors-intestinal bacteria-metabolites” inter- and inner-layer networks

Data availability

Data will be made available on request.

© 2023 The Authors. Published by Elsevier Inc.

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