Kanthan R, Senger JL, Ahmed S, Kanthan SC. Gallbladder Cancer in the 21st Century. J Oncol. 2015;2015:967472. https://doi.org/10.1155/2015/967472.

Article  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  PubMed  Google Scholar 

Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol. 2003;4(3):167–76. https://doi.org/10.1016/s1470-2045(03)01021-0.

Article  PubMed  Google Scholar 

Rakic M, Patrlj L, Kopljar M, Klicek R, Kolovrat M, Loncar B, Busic Z. Gallbladder cancer. Hepatobiliary Surg Nutr. 2014;3(5):221–6. https://doi.org/10.3978/j.issn.2304-3881.2014.09.03.

Article  PubMed  PubMed Central  Google Scholar 

Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M. Surgical Treatments of Hepatobiliary Cancers. Hepatology. 2021;73(Suppl 1):128–36. https://doi.org/10.1002/hep.31325.

Article  PubMed  Google Scholar 

Garg PK, Pandey D, Sharma J. The surgical management of gallbladder cancer. Expert Rev Gastroenterol Hepatol. 2015;9(2):155–66. https://doi.org/10.1586/17474124.2014.943188.

Article  CAS  PubMed  Google Scholar 

Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99–109. https://doi.org/10.2147/CLEP.S37357.

Article  PubMed  PubMed Central  Google Scholar 

Garcia-Recio S, Gascon P. Biological and Pharmacological Aspects of the NK1-Receptor. Biomed Res Int. 2015;2015:495704. https://doi.org/10.1155/2015/495704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muñoz M, Coveñas R. Involvement of substance P and the NK-1 receptor in human pathology. Amino Acids. 2014;46(7):1727–50. https://doi.org/10.1007/s00726-014-1736-9.

Article  CAS  PubMed  Google Scholar 

Zieglgansberger W. Substance P and pain chronicity. Cell Tissue Res. 2019;375(1):227–41. https://doi.org/10.1007/s00441-018-2922-y.

Article  CAS  PubMed  Google Scholar 

Tuluc F, Lai JP, Kilpatrick LE, Evans DL, Douglas SD. Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol. 2009;30(6):271–6. https://doi.org/10.1016/j.it.2009.03.006.

Article  CAS  PubMed  Google Scholar 

Friess H, Zhu Z, Liard V, Shi X, Shrikhande SV, Wang L, Lieb K, Korc M, Palma C, Zimmermann A, et al. Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer. Lab Invest. 2003;83(5):731–42. https://doi.org/10.1097/01.lab.0000067499.57309.f6.

Article  CAS  PubMed  Google Scholar 

Munoz M, Rosso M, Robles-Frias MJ, Salinas-Martin MV, Rosso R, Gonzalez-Ortega A, Covenas R. The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines. Lab Invest. 2010;90(8):1259–69. https://doi.org/10.1038/labinvest.2010.92.

Article  CAS  PubMed  Google Scholar 

Dong J, Feng F, Xu G, Zhang H, Hong L, Yang J. Elevated SP/NK-1R in esophageal carcinoma promotes esophageal carcinoma cell proliferation and migration. Gene. 2015;560(2):205–10. https://doi.org/10.1016/j.gene.2015.02.002.

Article  CAS  PubMed  Google Scholar 

Munoz M, Rosso M, Covenas R. Neurokinin-1 Receptor Antagonists against Hepatoblastoma. Cancers (Basel) 2019;11(9). https://doi.org/10.3390/cancers11091258.

Wang F, Liu S, Liu J, Feng F, Guo Y, Zhang W, Zheng G, Wang Q, Cai L, Guo M, et al. SP promotes cell proliferation in esophageal squamous cell carcinoma through the NK1R/Hes1 axis. Biochem Biophys Res Commun. 2019;514(4):1210–6. https://doi.org/10.1016/j.bbrc.2019.05.092.

Article  CAS  PubMed  Google Scholar 

Feng F, Yang J, Tong L, Yuan S, Tian Y, Hong L, Wang W, Zhang H. Substance P immunoreactive nerve fibres are related to gastric cancer differentiation status and could promote proliferation and migration of gastric cancer cells. Cell Biol Int. 2011;35(6):623–9. https://doi.org/10.1042/CBI20100229.

Article  CAS  PubMed  Google Scholar 

Mehboob R, Tanvir I, Warraich RA, Perveen S, Yasmeen S, Ahmad FJ. Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma. Pathol Res Pract. 2015;211(3):203–7. https://doi.org/10.1016/j.prp.2014.09.016.

Article  CAS  PubMed  Google Scholar 

Castro TA, Cohen MC, Rameshwar P. The expression of neurokinin-1 and preprotachykinin-1 in breast cancer cells depends on the relative degree of invasive and metastatic potential. Clin Exp Metastasis. 2005;22(8):621–8. https://doi.org/10.1007/s10585-006-9001-6.

Article  CAS  PubMed  Google Scholar 

Deng XT, Tang SM, Wu PY, Li QP, Ge XX, Xu BM, Wang HS, Miao L. SP/NK-1R promotes gallbladder cancer cell proliferation and migration. J Cell Mol Med. 2019;23(12):7961–73. https://doi.org/10.1111/jcmm.14230.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aapro M, Carides A, Rapoport BL, Schmoll HJ, Zhang L, Warr D. Aprepitant and fosaprepitant: a 10-year review of efficacy and safety. Oncologist. 2015;20(4):450–8. https://doi.org/10.1634/theoncologist.2014-0229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munoz M, Covenas R. The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer? Cancers (Basel) 2020;12(9). https://doi.org/10.3390/cancers12092682.

Javid H, Afshari AR, Zahedi Avval F, Asadi J, Hashemy SI. Aprepitant Promotes Caspase-Dependent Apoptotic Cell Death and G2/M Arrest through PI3K/Akt/NF-kappaB Axis in Cancer Stem-Like Esophageal Squamous Cell Carcinoma Spheres. Biomed Res Int. 2021;2021:8808214. https://doi.org/10.1155/2021/8808214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, et al. Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo. Drug Des Devel Ther. 2020;14:2413–22. https://doi.org/10.2147/DDDT.S244648.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munoz M, Berger M, Rosso M, Gonzalez-Ortega A, Carranza A, Covenas R. Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol. 2014;44(1):137–46. https://doi.org/10.3892/ijo.2013.2164.

Article  CAS  PubMed  Google Scholar 

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998;281(5383):1640–5. https://doi.org/10.1126/science.281.5383.1640.

Article  CAS  PubMed  Google Scholar 

Munoz M, Rosso M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest New Drugs. 2010;28(2):187–93. https://doi.org/10.1007/s10637-009-9218-8.

Article  CAS  PubMed  Google Scholar 

Stuelten CH, Parent CA, Montell DJ. Cell motility in cancer invasion and metastasis: insights from simple model organisms. Nat Rev Cancer. 2018;18(5):296–312. https://doi.org/10.1038/nrc.2018.15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010;141(1):52–67. https://doi.org/10.1016/j.cell.2010.03.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malireddi RKS, Karki R, Sundaram B, Kancharana B, Lee S, Samir P, Kanneganti TD. Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth. Immunohorizons. 2021;5(7):568–80. https://doi.org/10.4049/immunohorizons.2100059.

Article  CAS  PubMed  Google Scholar 

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, Li Y. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021;6(1):263. https://doi.org/10.1038/s41392-021-00658-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol. 2011;12(8):715–23. https://doi.org/10.1038/ni.2060.

Article  CAS  PubMed  Google Scholar 

Wu Q, Wu W, Fu B, Shi L, Wang X, Kuca K. JNK signaling in cancer cell survival. Med Res Rev. 2019;39(6):2082–104. https://doi.org/10.1002/med.21574.

Article  CAS  PubMed  Google Scholar 

Ji C, Guo H, Zhang P, Kuang W, Fan Y, Wu L. AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-kappaB signaling pathway. J Neurooncol. 2018;138(3):469–78. https://doi.org/10.1007/s11060-018-2818-4.

Article  CAS  PubMed  Google Scholar 

Malenica I, Donadon M, Lleo A. Molecular and Immunological Characterization of Biliary Tract Cancers: A Paradigm Shift Towards a Personalized Medicine. Cancers (Basel) 2020;12(8). https://doi.org/10.3390/cancers12082190.

Tariq NU, McNamara MG, Valle JW. Biliary tract cancers: current knowledge, clinical candidates and future challenges. Cancer Manag Res. 2019;11:2623–42. https://doi.org/10.2147/CMAR.S157092.

Article  CAS  PubMed