The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration

AMPK

AMP-activated protein kinase

CaMK

Ca²⁺/calmodulin-dependent protein kinase

CJD

Creutzfeldt-Jakob Disease

ERR-α

estrogen-related receptor-α

ETC

electron transport chain

HSP

promoter of the heavy strand

LHON

Leber's hereditary optic neuropathy

MCI

mild cognitive impairment

MELAS

mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes

MERFF

myoclonus epilepsy with ragged-red fibers

mtDNA4977

mtDNA deletion of 4977 bp

NRF

nuclear respiratory factor

NUMTs

nuclear-encoded mitochondrial sequences

OriH

origin of replication of the heavy mtDNA strand

OriL

origin of replication of the light mtDNA strand

PGC-1α

proliferator-activated receptor gamma coactivator 1-alpha

TFAM

mitochondrial transcription factor A

TFBM

mitochondrial transcription factor B

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