Second Trimester Medication Abortion Regimens and the Mifepristone-Misoprostol Dosing Interval

Cohen MA, Kapp N, Edelman A. Abortion care beyond 13 weeks’ gestation: a global perspective. Clin Obstet Gynecol. 2021;64(3):460–74.

Article  PubMed  Google Scholar 

Dodd JM, Crowther CA. Misoprostol for induction of labour to terminate pregnancy in the second or third trimester for women with a fetal anomaly or after intrauterine fetal death. Cochrane Database of Syst Rev 2010;4:CD004901. https://doi.org/10.1002/14651858.CD004901.pub2. Accessed 07 December 2022.

Abediasl Z, Sheikh M, Pooransari P, Farahani Z, Kalani F. Vaginal misoprostol versus intravenous oxytocin for the management of second-trimester pregnancies with intrauterine fetal death: a randomized clinical trial. J Obstet Gynaecol Res. 2016;42(3):246–51.

Article  CAS  PubMed  Google Scholar 

The Care of Women Requesting Induced Abortion (Evidence-based Clinical Guideline No. 7). Royal College of Obstetricians & Gynaecologists (RCOG). November 2011, reaffirmed 2018.

Abortion care guideline. Geneva: World Health Organization (WHO); 2022. License: CC BY-NC-SA 3.0 IGO.

Anselem O, Jouannic JM, Winer N, Bouchghoul H, Vivanti AJ, Quibel T, Massardier J, Rousseau J, Ancel PY, Goffinet F, Tsatsaris V. Cervical dilators used concurrently with misoprostol to shorten labor in second-trimester termination of pregnancy: a randomized controlled trial. Obstet Gynecol. 2022 Sep 1;140(3):453–460. https://doi.org/10.1097/AOG.0000000000004887. Epub 2022 Aug 3. Erratum in: Obstet Gynecol. 2022;140(5):902. PMID:35,926,202.

Dickinson JE, Evans SF. A comparison of oral misoprostol with vaginal misoprostol administration in second-trimester pregnancy termination for fetal abnormality. Obstet Gynecol. 2003;101(6):1294–9.

CAS  PubMed  Google Scholar 

Green J, Borgatta L, Sia M, Kapp N, Saia K, Carr-Ellis S, Vragovic O. Interventions rates for placental removal following induction abortion with misoprostol. Contraception. 2007;76(4):310–3.

Article  CAS  PubMed  Google Scholar 

Berghella V, Airoldi J, O’Neill AM, Einhorn K, Hoffman M. Misoprostol for second trimester pregnancy termination in women with prior cesarean: a systematic review. BJOG. 2009;116:1151–7.

Article  CAS  PubMed  Google Scholar 

Borgatta L, Kapp N. Society of Family Planning. Clinical guidelines. Labor induction abortion in the second trimester Contraception. 2011;84(1):4–18. https://doi.org/10.1016/j.contraception.2011.02.005. Epub 2011 Mar 30. PMID:21664506.

Article  PubMed  Google Scholar 

Perritt JB, Burke A, Edelman AB. Interruption of nonviable pregnancies of 24–28 weeks’ gestation using medical methods: release date June 2013 SFP guideline #20,133. Contraception. 2013;88(3):341–9.

Article  PubMed  Google Scholar 

Vlad S, Boucoiran I, St-Pierre ÉR, Ferreira E. Mifepristone-misoprostol use for second- and third-trimester medical termination of pregnancy in a Canadian tertiary care centre. J Obstet Gynaecol Can. 2022;44(6):683–689. https://doi.org/10.1016/j.jogc.2021.12.010. Epub 2022 Feb 1. PMID:35,114,381.

Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N. Medical methods for mid-trimester termination of pregnancy. Cochrane Database Syst Rev. 2011;2011(1):CD005216. https://doi.org/10.1002/14651858.CD005216.pub2. PMID:21,249,669; PMCID:PMC8557267.

Prodan N, Breisch J, Hoopmann M, Abele H, Wagner P, Kagan KO. Dosing interval between mifepristone and misoprostol in second and third trimester termination. Arch Gynecol Obstet. 2019;299(3):675–679. https://doi.org/10.1007/s00404-018-5017-9. Epub 2018 Dec 21. PMID:30,578,439

•• Henkel A, Lerma K, Blumenthal PD, Shaw KA. Evaluation of shorter mifepristone to misoprostol intervals for second trimester medical abortion: a retrospective cohort study. Contraception. 2020 Nov;102(5):327–331. https://doi.org/10.1016/j.contraception.2020.06.009. Epub 2020 Jun 25. PMID:32,592,800. A retrospective review of 89 persons with gestations 15–27 weeks who received misoprostol and mifepristone at different dosing intervals (less than 12 h, 12–24 h, and greater than 24 h) and a subsequent analysis of total induction time as well as total abortion time.

•• Shay RL, Benson LS, Lokken EM, Micks EA. Same-day mifepristone prior to second-trimester induction termination with misoprostol: a retrospective cohort study. Contraception. 2022;107:29–35. https://doi.org/10.1016/j.contraception.2021.09.006. Epub 2021 Sep 13. PMID:34,529,952. A retrospective review of 298 persons with gestations 14–28 weeks who received misoprostol and mifepristone at varying intervals and an analysis of time to fetal expulsion.

Allanson ER, Copson S, Spilsbury K, et al. Pretreatment with mifepristone compared with misoprostol alone for delivery after fetal death between 14 and 28 weeks of gestation: a randomized controlled trial. Obstet Gynecol. 2021;137(5):801–9. https://doi.org/10.1097/AOG.0000000000004344.

Article  CAS  PubMed  Google Scholar 

Dadhwal V, Garimella S, Khoiwal K, Sharma KA, Perumal V, Deka D. Mifepristone followed by misoprostol or ethacridine lactate and oxytocin for second trimester abortion: a randomized trial. Eurasian J Med. 2019;51(3):262–266. https://doi.org/10.5152/eurasianjmed.2019.18341. Epub 2019 Aug 19. PMID:31,692,613; PMCID:PMC6812907.

Whitehouse KC, Stifani BM, Duffy JMN, Kim CR, Creinin MD, DePiñeres T, Winikoff B, Gemzell-Danielsson K, Blum J, Sherman RB, Lavelanet AF, Brahmi D, Grossman D, Tamang Gebreselassie H, Ponce de Leon RG, Ganatra B. Standardizing abortion research outcomes (STAR): results from an international consensus development study. Contraception. 2021 Nov;104(5):484–491. https://doi.org/10.1016/j.contraception.2021.07.004. Epub 2021 Jul 14. PMID:34,273,335; PMCID:PMC8609158.

National Guideline Alliance (UK). Medical abortion after 24 weeks’ gestation: abortion care: evidence review L. London: National Institute for Health and Care Excellence (NICE); 2019 Sep. PMID:32,813,471.

Valero I, Garcia-Jimenez R, Weber-Fernandez AM, et al. Combination of mifepristone and misoprostol vs misoprostol monotherapy for treatment of second-trimester pregnancy loss. Eur J Contracept Reprod Health Care. 2022;27(4):341–4. https://doi.org/10.1080/13625187.2022.2054982.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif