Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.

Fungal infection

Aspergillus

Fusarium

Candida

Innate immunity

Neutrophil

Cornea

Keratitis

Ocular infection

Reactive oxygen species

NADPH oxidase

Nutritional immunity

Cytokines

IL-1 alpha

IL-1 beta

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