Prakash O, Varghese BT, Mathews A, Nayak N, Ramchandran K, Pandey M. Radiation induced osteogenic sarcoma of the maxilla. World J Surg Oncol. 2005;3:49.

Article  PubMed  PubMed Central  Google Scholar 

Boon E, Van Der Graaf WTA, Gelderblom H, Tesselaar MET, Van Es RJJ, Oosting SF, et al. Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults. Head Neck. 2017;39(1):140–6.

Article  PubMed  Google Scholar 

Krishnamurthy A, Palaniappan R. Osteosarcomas of the head and neck region: a case series with a review of literature. J Maxillofac Oral Surg. 2018;17(1):38–43.

Article  PubMed  Google Scholar 

Clark JL, Unni KK, Dahlin DC, Devine KD. Osteosarcoma of the jaw. Cancer. 1983;51(12):2311–6.

Article  CAS  PubMed  Google Scholar 

Whelan JS, Jinks RC, McTiernan A, Sydes MR, Hook JM, Trani L, et al. Survival from high-grade localised extremity osteosarcoma: combined results and prognostic factors from three European Osteosarcoma Intergroup randomised controlled trials. Ann Oncol. 2012;23(6):1607–16.

Article  CAS  PubMed  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA: A Cancer J Clin. 2023;73(1):17–48.

Google Scholar 

American Cancer Society. Key Statistics for Osteosarcoma 2020 [Available from: https://www.cancer.org/cancer/osteosarcoma/about/key-statistics.html.

Howlader N NA, Krapcho M et al. SEER Cancer Statistics Review, 1975–2018, National Cancer Institute. Bethesda, MD, based on November 2020 SEER data submission. 2021.

Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL, Hokanson JA. Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope. 1997;107(1):56–61.

Article  CAS  PubMed  Google Scholar 

Meng J, Wu J, Zhang X, Guo L, Li H. A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: a cohort study. Medicine (Baltimore). 2022;101(42): e30981.

Article  PubMed  Google Scholar 

Hegyi M, Semsei AF, Jakab Z, Antal I, Kiss J, Szendroi M, et al. Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. Pediatr Blood Cancer. 2011;57(3):415–22.

Article  PubMed  Google Scholar 

Yu S, Fourman MS, Mahjoub A et al. Lung cells support osteosarcoma cell migration and survival. BMC Cancer 2017;17, 78. https://doi.org/10.1186/s12885-017-3047-5.

Kaneuchi Y, Hakozaki M, Yamada H, Hasegawa O, Yamada S, Oka Y, et al. Very late relapse of high-grade osteosarcoma: A case report and review of the literature. Medicine. 2020;99(29): e21206.

Article  PubMed  PubMed Central  Google Scholar 

Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3–13.

Article  PubMed  Google Scholar 

Cassoni A, Brauner E, Pucci R, et al. Head and neck osteosarcoma-the ongoing challenge about reconstruction and dental rehabilitation. Cancers (Basel). 2020;12(7):1948. https://doi.org/10.3390/cancers12071948.

Thiele OC, Freier K, Bacon C, Egerer G, Hofele CM. Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study. Br J Oral Maxillofac Surg. 2008;46(7):533–6.

Article  PubMed  Google Scholar 

• Mendenhall WM, Fernandes R, Werning JW, Vaysberg M, Malyapa RS, Mendenhall NP. Head and neck osteosarcoma. Am J Otolaryngol. 2011;32(6):597–600. These references are of importance as they highlight the significance of obtaining negative surgical margins and the survival advantages in head and neck osteosarcoma patients without residual post-operative disease.

Article  PubMed  Google Scholar 

Huayllani MT, Restrepo DJ, Boczar D, Sisti A, Spaulding AC, Parker AS, et al. Osteosarcoma of the upper extremities: a national analysis of the US population. Anticancer Res. 2019;39(10):5663–8.

Article  PubMed  Google Scholar 

•• Guadagnolo BA, Zagars GK, Raymond AK, Benjamin RS, Sturgis EM. Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. Cancer. 2009;115(14):3262–70. This reference is of outstanding importance as it is one of the first studies to demonstrate that radiotherapy in addition to surgery improves overall survival, disease free survival, and local control in head and neck osteosarcoma patients with positive surgical margins.

Article  PubMed  Google Scholar 

 Odri GA, Tchicaya-Bouanga J, Yoon DJY, Modrowski D. Metastatic progression of osteosarcomas: a review of current knowledgeof environmental versus oncogenic drivers. Cancers (Basel). 2022;14(2):360. https://doi.org/10.3390/cancers14020360.

Meazza C, Scanagatta P. Metastatic osteosarcoma: a challenging multidisciplinary treatment. Expert Rev Anticancer Ther. 2016;16(5):543–56.

Article  CAS  PubMed  Google Scholar 

Mutsaers AJ, Walkley CR. Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells? Bone. 2014;62:56–63.

Article  PubMed  Google Scholar 

Fletcher CDM, et al. Pathology and genetics of tumours of soft tissue and bone: who classification of tumours. World Health Organization, 2002;5.

Fuchs B, Pritchard DJ. Etiology of osteosarcoma. Clin Orthop Relat Res. 2002;397:40–52.

Article  Google Scholar 

Chen Y, Shen Q, Gokavarapu S, Lin C, Yahiya, Cao W et al. Osteosarcoma of head and neck: a retrospective study on prognostic factors from a single institute database. Oral Oncol. 2016;58:1–7.

Cheng L, Pandya PH, Liu E, Chandra P, Wang L, Murray ME, et al. Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma. BMC Med Genom. 2019;12(Suppl 1):23.

Article  Google Scholar 

Mirabello L, Zhu B, Koster R, Karlins E, Dean M, Yeager M, et al. Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma. JAMA Oncol. 2020;6(5):724.

Article  PubMed  PubMed Central  Google Scholar 

Angelini A, Mavrogenis AF, Trovarelli G, Ferrari S, Picci P, Ruggieri P. Telangiectatic osteosarcoma: a review of 87 cases. J Cancer Res Clin Oncol. 2016;142(10):2197–207.

Article  PubMed  Google Scholar 

Bertoni F, Bacchini P, Fabbri N, Mercuri M, Picci P, Ruggieri P, et al. Osteosarcoma low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 1993;71(2):338–45.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Rosenberg AE. Bone-forming tumors. Surg Pathol Clin. 2017;10(3):513–35.

Article  PubMed  Google Scholar 

Baumhoer D. Bone-related lesions of the jaws. Surg Pathol Clin. 2017;10(3):693–704.

Article  PubMed  Google Scholar 

Bertin H, Gomez-Brouchet A, Redini F. Osteosarcoma of the jaws: an overview of the pathophysiological mechanisms. Crit Rev Oncol Hematol. 2020;156: 103126.

Article  PubMed  Google Scholar 

Mirabello L, Troisi RJ, Savage SA. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer. 2009;125(1):229–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG. Sarcomas of the head and neck. Prognostic factors and treatment strategies. Cancer. 1992;70(1):169–77.

Article  CAS  PubMed  Google Scholar 

Carrle D, Bielack SS. Current strategies of chemotherapy in osteosarcoma. Int Orthop. 2006;30(6):445–51.

Article  PubMed  PubMed Central  Google Scholar 

Tsukamoto S, Righi A, Kido A, Honoki K, Tanaka Y, Fujii H, et al. Effect of adjuvant chemotherapy on periosteal osteosarcoma: a systematic review. Jpn J Clin Oncol. 2022;52(8):896–904.

Article  PubMed  Google Scholar 

DeAngelis AF, Spinou C, Tsui A, Iseli T, Desai J, Wiesenfeld D, et al. Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases. J Oral Maxillofac Surg. 2012;70(3):734–9.

Article  PubMed  Google Scholar 

Laskar S, Basu A, Muckaden MA, D’Cruz A, Pai S, Jambhekar N, et al. Osteosarcoma of the head and neck region: lessons learned from a single-institution experience of 50 patients. Head Neck. 2008;30(8):1020–6.

Article  PubMed  Google Scholar 

• Bertrand TE, Cruz A, Binitie O, Cheong D, Letson GD. Do surgical margins affect local recurrence and survival in extremity, nonmetastatic, high-grade osteosarcoma? Clin Orthop Relat Res. 2016;474(3):677–83. These references are of importance as they highlight the significance of obtaining negative surgical margins and the survival advantages in osteosarcoma patients without residual post-operative disease.

Article  PubMed  Google Scholar 

Lee RJ, Arshi A, Schwartz HC, Christensen RE. Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study. JAMA Otolaryn Head Neck Surg. 2015;141(5):470–7.

Article  Google Scholar 

Chen EL, Yoo CH, Gutkin PM, Merriott DJ, Avedian RS, Steffner RJ, et al. Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy. Pediatr Blood Cancer. 2020;67(1): e27967.

Article  PubMed  Google Scholar 

Grewal AS, Jones J, Lin A. Palliative radiation therapy for head and neck cancers. Int J Radiat Oncol Biol Phys. 2019;105(2):254–66.

Article  PubMed  Google Scholar 

•• Chen Y, Gokavarapu S, Shen Q, Liu F, Cao W, Ling Y, et al. Chemotherapy in head and neck osteosarcoma: adjuvant chemotherapy improves overall survival. Oral Oncol. 2017;73:124–31. This reference is of outstanding importance as it is highlights the largest retrospective single institution study investigating the role of chemotherapy in the management of head and neck osteosarcoma patients, and demonstrates improvement in overall survival in HNOS patients treated with adjuvant chemotherapy.

Article  CAS  PubMed  Google Scholar 

Anninga JK, Gelderblom H, Fiocco M, Kroep JR, Taminiau AH, Hogendoorn PC, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431–45.

Article  CAS  PubMed  Google Scholar 

Bacci G, Bertoni F, Longhi A, Ferrari S, Forni C, Biagini R, et al. Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor. Cancer. 2003;97(12):3068–75.

Article