Orexin
Orexin receptor antagonist
Sleep
Sleep disorders
Seizure
Epilepsy
Abbreviations5-HT5-hydroxytriptophan or serotonin
AMPAα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
cAMPcyclic adenosine monophosphate
CNScentral nervous system
DORAsdual OXR antagonists
EEGelectroencephalography
ERKextracellular signal-regulated kinase
FDAfood and drug administration
GPCRsG-protein-coupled receptors
IEDsinterictal epileptiform discharges
LDTlaterodorsal tegmental nucleus
LHAlateral hypothalamic area
MAPKmitogen-activated protein kinase
non-REM or NREMnon-rapid eye movement
OX1Rorexin receptor type 1
OX2Rorexin receptor type 2
PNSperipheral nervous system
PPTpedunculopontine tegmental nucleus
SORAsselective OXR antagonists
TMNtuberomammillary nucleus
VTAventral tegmental area
WAG/Rijwistar albino glaxo rijswijk;
Data availabilityThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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