Introduction The prognosis of patients with acute kidney injury (AKI) caused by type 1 cardiorenal syndrome (CRS) requiring continuous renal replacement therapy (CRRT) is unclear. We investigated the in-hospital mortality and prognostic factors in these patients. Methods We retrospectively identified 154 consecutive adult patients who received CRRT for AKI caused by type 1 CRS between January 1, 2013, and December 31, 2019. We excluded patients who underwent cardiovascular surgery and those with chronic kidney disease stage 5. The primary outcome was in-hospital mortality. Cox proportional hazards analysis was performed to analyze independent predictors of in-hospital mortality. Results The median age of patients at admission was 74.0 years (interquartile range: 63.0–80.0); 70.8% were male. The in-hospital mortality rate was 68.2%. Age ≥80 years (hazard ratio, 1.87; 95% confidence interval [CI], 1.21–2.87; P=0.004); previous hospitalization for acute heart failure (hazard ratio, 1.67; 95% CI, 1.13–2.46; P=0.01), vasopressor or inotrope use (hazard ratio, 5.88; 95% CI, 1.43 – 24.1; P=0.014), and mechanical ventilation (hazard ratio, 2.24; 95% CI, 1.46 –3.45; P

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