Alkatout I, Schubert M, Garbrecht N, Weigel MT, Jonat W, Mundhenke C, Gunther V (2015) Vulvar cancer: epidemiology, clinical presentation, and management options. Int J Womens Health 7:305–313. https://doi.org/10.2147/IJWH.S68979

Article  PubMed  PubMed Central  Google Scholar 

Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, Peiffert D, van Glabbeke M, Pierart M (1997) Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15(5):2040–2049. https://doi.org/10.1200/JCO.1997.15.5.2040

Article  CAS  PubMed  Google Scholar 

Beriwal S, Heron DE, Kim H, King G, Shogan J, Bahri S, Gerszten K, Lee J, Kelley J, Edwards RP (2006) Intensity-modulated radiotherapy for the treatment of vulvar carcinoma: a comparative dosimetric study with early clinical outcome. Int J Radiat Oncol Biol Phys 64(5):1395–1400. https://doi.org/10.1016/j.ijrobp.2005.11.007

Article  PubMed  Google Scholar 

Cunningham MJ, Goyer RP, Gibbons SK, Kredentser DC, Malfetano JH, Keys H (1997) Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva. Gynecol Oncol 66(2):258–261. https://doi.org/10.1006/gyno.1997.4758

Article  CAS  PubMed  Google Scholar 

Dass PH, Kuper-Hommel MJ (2017) A review of squamous cell vulvar cancers in Waikato region, New Zealand. N Z Med J 130(1465): 19–28. https://www.ncbi.nlm.nih.gov/pubmed/29121621

Eifel PJ, Morris M, Burke TW, Levenback C, Gershenson DM (1995) Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva. Gynecol Oncol 59(1):51–56. https://doi.org/10.1006/gyno.1995.1267

Article  CAS  PubMed  Google Scholar 

ESGO-Guidelines (2016) Vulvar-cancer-complete-report-fxd2.pdf; Retrieved from: https://guidelines.esgo.org/vulvar-cancer/guidelines/recommendations/, 27.01.2022.

Flam M, John M, Pajak TF, Petrelli N, Myerson R, Doggett S, Quivey J, Rotman M, Kerman H, Coia L, Murray K (1996) Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 14(9):2527–2539. https://doi.org/10.1200/JCO.1996.14.9.2527

Article  CAS  PubMed  Google Scholar 

Ghebre RG, Posthuma R, Vogel RI, Geller MA, Carson LF (2011) Effect of age and comorbidity on the treatment and survival of older patients with vulvar cancer. Gynecol Oncol 121(3):595–599. https://doi.org/10.1016/j.ygyno.2011.02.005

Article  PubMed  PubMed Central  Google Scholar 

Han SC, Kim DH, Higgins SA, Carcangiu ML, Kacinski BM (2000) Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva. Int J Radiat Oncol Biol Phys 47(5):1235–1244. https://doi.org/10.1016/s0360-3016(00)00569-1

Article  CAS  PubMed  Google Scholar 

Kang YJ, Smith M, Barlow E, Coffey K, Hacker N, Canfell K (2017) Vulvar cancer in high-income countries: Increasing burden of disease. Int J Cancer 141(11):2174–2186. https://doi.org/10.1002/ijc.30900

Article  CAS  PubMed  Google Scholar 

Landoni F, Maneo A, Zanetta G, Colombo A, Nava S, Placa F, Tancini G, Mangioni C (1996) Concurrent preoperative chemotherapy with 5-fluorouracil and mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma. Gynecol Oncol 61(3):321–327. https://doi.org/10.1006/gyno.1996.0150

Article  CAS  PubMed  Google Scholar 

Lupi G, Raspagliesi F, Zucali R, Fontanelli R, Paladini D, Kenda R, di Re F (1996) Combined preoperative chemoradiotherapy followed by radical surgery in locally advanced vulvar carcinoma a Pilot Study. Cancer 77(8):1472–1478. https://doi.org/10.1002/(SICI)1097-0142(19960415)77:8%3c1472::AID-CNCR8%3e3.0.CO;2-E

Article  CAS  PubMed  Google Scholar 

Mak RH, Halasz LM, Tanaka CK, Ancukiewicz M, Schultz DJ, Russell AH, Viswanathan AN (2011) Outcomes after radiation therapy with concurrent weekly platinum-based chemotherapy or every-3-4-week 5-fluorouracil-containing regimens for squamous cell carcinoma of the vulva. Gynecol Oncol 120(1):101–107. https://doi.org/10.1016/j.ygyno.2010.09.004

Article  CAS  PubMed  Google Scholar 

Meta-Analysis Group In Cancer, Lévy E, Buyse M, Pignon JP, Rougier P, Ryan L, Hansen R, Zee B, Weinerman B, Pater J, Leichman C, Macdonald J, Benedetti J, Lokich J, Fryer J, Brufman G, Isacson R, Laplanche A, Quinaux E, Thirion P (1998) Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. J Clin Oncol 16(11):3537–3541. https://doi.org/10.1200/JCO.1998.16.11.3537

Article  Google Scholar 

Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL (2012) A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study. Gynecol Oncol 124(3):529–533. https://doi.org/10.1016/j.ygyno.2011.11.003

Article  CAS  PubMed  Google Scholar 

Moore DH, Thomas GM, Montana GS, Saxer A, Gallup DG, Olt G (1998) Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys 42(1):79–85. https://doi.org/10.1016/s0360-3016(98)00193-x

Article  CAS  PubMed  Google Scholar 

Mulayim N, Foster Silver D, Schwartz PE, Higgins S (2004) Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma. Gynecol Oncol 93(3):659–666. https://doi.org/10.1016/j.ygyno.2004.03.019

Article  CAS  PubMed  Google Scholar 

Nagel G, Concin H, Bjorge T, Rapp K, Manjer J, Hallmans G, Diem G, Haggstrom C, Engeland A, Almquist M, Jonsson H, Selmer R, Stocks T, Tretli S, Ulmer H, Stattin P, Lukanova A (2011) Metabolic syndrome and rare gynecological cancers in the metabolic syndrome and cancer project (Me-Can). Ann Oncol 22(6):1339–1345. https://doi.org/10.1093/annonc/mdq597

Article  CAS  PubMed  Google Scholar 

Oonk MHM, Planchamp F, Baldwin P, Bidzinski M, Brannstrom M, Landoni F, Mahner S, Mahantshetty U, Mirza M, Petersen C, Querleu D, Regauer S, Rob L, Rouzier R, Ulrikh E, van der Velden J, Vergote I, Woelber L, van der Zee AGJ (2017) European society of gynaecological oncology guidelines for the management of patients with vulvar cancer. Int J Gynecol Cancer 27(4):832–837. https://doi.org/10.1097/IGC.0000000000000975

Article  PubMed  Google Scholar 

Rao YJ, Chin RI, Hui C, Mutch DG, Powell MA, Schwarz JK, Grigsby PW, Markovina S (2017) Improved survival with definitive chemoradiation compared to definitive radiation alone in squamous cell carcinoma of the vulva: a review of the National Cancer Database. Gynecol Oncol 146(3):572–579. https://doi.org/10.1016/j.ygyno.2017.06.022

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Article  PubMed  Google Scholar 

Tagliaferri L, Lancellotta V, Casa C, Fragomeni SM, Ferioli M, Gentileschi S, Caretto AA, Corrado G, Gui B, Colloca GF, Gambacorta MA, Morganti AG, Garganese G, Macchia G (2021) The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: a multidisciplinary VulCan team review. Cancers. https://doi.org/10.3390/cancers13225747

Article  PubMed  PubMed Central  Google Scholar 

Tans L, Ansink AC, van Rooij PH, Kleijnen C, Mens JW (2011) The role of chemo-radiotherapy in the management of locally advanced carcinoma of the vulva: single institutional experience and review of literature. Am J Clin Oncol 34(1):22–26. https://doi.org/10.1097/COC.0b013e3181cae6a1

Article  PubMed  Google Scholar 

Tebbutt NC, Norman AR, Cunningham D, Allen M, Chau I, Oates J, Hill M (2003) Analysis of the time course and prognostic factors determining toxicity due to infused fluorouracil. Br J Cancer 88(10):1510–1515. https://doi.org/10.1038/sj.bjc.6600917

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Triest B, Rasing M, van der Velden J, de Hullu J, Witteveen PO, Beukema JC, van der Steen-Banasik E, Westerveld H, Snyers A, Peters M, Creutzberg CL, Nout RA, Lutgens L, Jurgenliemk-Schulz I (2021) Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva: An efficacy study. Gynecol Oncol 163(1):117–124. https://doi.org/10.1016/j.ygyno.2021.07.020

Article  CAS  PubMed  Google Scholar