Lees B, Meredith LR, Kirkland AE, Bryant BE, Squeglia LM. Effect of alcohol use on the adolescent brain and behavior. Pharmacol Biochem Behav. 2020;192:172906.

Article  CAS  PubMed  PubMed Central  Google Scholar 

World Health Organization. Global status report on alcohol and health 2018: World Health Organization; 2019.

Sun D, Adduru VR, Phillips RD, Bouchard HC, Sotiras A, Michael AM, et al. Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach. Neuropsychopharmacology. 2022;11:1–10.

Lees B, Debenham J, Squeglia LM. Alcohol and cannabis use and the developing brain. Alcohol Res: Curr Rev. 2021;41:11.

Lees B, Mewton L, Stapinski LA, Squeglia LM, Rae CD, Teesson M. Neurobiological and cognitive profile of young binge drinkers: a systematic review and meta-analysis. Neuropsychol Rev. 2019;29:357–85.

Article  PubMed  PubMed Central  Google Scholar 

Crews FT, Robinson DL, Chandler LJ, Ehlers CL, Mulholland PJ, Pandey SC, et al. Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings. Alcohol: Clin Exp Res. 2019;43:1806–22.

Article  PubMed  Google Scholar 

Gowin JL, Sloan ME, Stangl BL, Vatsalya V, Ramchandani VA. Vulnerability for alcohol use disorder and rate of alcohol consumption. Am J Psychiatry. 2017;174:1094–101.

Article  PubMed  PubMed Central  Google Scholar 

Addolorato G, Vassallo GA, Antonelli G, Antonelli M, Tarli C, Mirijello A, et al. Binge drinking among adolescents is related to the development of alcohol use disorders: results from a cross-sectional study. Sci Rep. 2018;8:1–9.

Google Scholar 

Olsson CA, Romaniuk H, Salinger J, Staiger PK, Bonomo Y, Hulbert C, et al. Drinking patterns of adolescents who develop alcohol use disorders: results from the Victorian Adolescent Health Cohort Study. BMJ Open. 2016;6:e010455.

Article  PubMed  PubMed Central  Google Scholar 

Ehlers CL, Stouffer GM, Gilder DA. Associations between a history of binge drinking during adolescence and self‐reported responses to alcohol in young adult Native and Mexican Americans. Alcohol: Clin Exp Res. 2014;38:2039–47.

Article  PubMed  Google Scholar 

Fadus MC, Squeglia LM, Valadez EA, Tomko RL, Bryant BE, Gray KM. Adolescent substance use disorder treatment: an update on evidence-based strategies. Curr Psychiatry Rep. 2019;21:1–10.

Article  Google Scholar 

Jensen CD, Cushing CC, Aylward BS, Craig JT, Sorell DM, Steele RG. Effectiveness of motivational interviewing interventions for adolescent substance use behavior change: a meta-analytic review. J Consult Clin Psychol. 2011;79:433.

Article  PubMed  Google Scholar 

Tripodi SJ, Bender K, Litschge C, Vaughn MG. Interventions for reducing adolescent alcohol abuse: a meta-analytic review. Arch Pediatr Adolesc Med. 2010;164:85–91.

Article  PubMed  Google Scholar 

Tanner-Smith EE, Lipsey MW. Brief alcohol interventions for adolescents and young adults: a systematic review and meta-analysis. J Subst Abus Treat. 2015;51:1–18.

Article  Google Scholar 

Chung T, Maisto SA. Relapse to alcohol and other drug use in treated adolescents: review and reconsideration of relapse as a change point in clinical course. Clin Psychol Rev. 2006;26:149–61.

Article  PubMed  Google Scholar 

Winters KC, Tanner-Smith EE, Bresani E, Meyers K. Current advances in the treatment of adolescent drug use. Adolesc Health, Med Ther. 2014;5:199.

PubMed  Google Scholar 

Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA. 2007;297:1683–96.

Article  CAS  PubMed  Google Scholar 

Balog-Way DH, Evensen D, Löfstedt RE. Pharmaceutical benefit–risk perception and age differences in the USA and Germany. Drug Saf. 2020;43:1141–56.

Article  CAS  PubMed  Google Scholar 

O’Callaghan FV, Jordan N. Postmodern values, attitudes and the use of complementary medicine. Complement Ther Med. 2003;11:28–32.

Article  PubMed  Google Scholar 

Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, et al. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. 2012;169:805–12.

Article  PubMed  PubMed Central  Google Scholar 

Kalivas P, Volkow N. New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry. 2011;16:974–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalivas PW, Volkow ND. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry. 2005;162:1403–13.

Article  PubMed  Google Scholar 

Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 2009;10:561–72.

Article  CAS  PubMed  Google Scholar 

McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM. Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs. 2014;28:95–106.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, et al. Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review. Neurosci Biobehav Rev. 2015;55:294–321.

Article  PubMed  Google Scholar 

Lebourgeois S, González‐Marín MC, Jeanblanc J, Naassila M, Vilpoux C. Effect of N‐acetylcysteine on motivation, seeking and relapse to ethanol self‐administration. Addict Biol. 2018;23:643–52.

Article  CAS  PubMed  Google Scholar 

Quintanilla ME, Rivera‐Meza M, Berríos‐Cárcamo P, Salinas‐Luypaert C, Herrera‐Marschitz M, Israel Y. Beyond the “first hit”: marked inhibition by N‐acetyl cysteine of chronic ethanol intake but not of early ethanol intake. Parallel effects on ethanol‐induced saccharin motivation. Alcohol: Clin Exp Res. 2016;40:1044–51.

Article  CAS  PubMed  Google Scholar 

Madayag A, Lobner D, Kau KS, Mantsch JR, Abdulhameed O, Hearing M, et al. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci. 2007;27:13968–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramirez-Niño AM, D’Souza MS, Markou A. N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology. 2013;225:473–82.

Article  PubMed  Google Scholar 

Olive MF, Cleva RM, Kalivas PW, Malcolm RJ. Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav. 2012;100:801–10.

Article  CAS  PubMed  Google Scholar 

Smaga I, Frankowska M, Filip M. N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research. Pharmacol Rep. 2021;73:1205–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Squeglia LM, Baker NL, McClure EA, Tomko RL, Adisetiyo V, Gray KM. Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation. Addict Behav. 2016;63:172–7.

Article  PubMed  PubMed Central  Google Scholar 

Squeglia LM, Tomko RL, Baker NL, McClure EA, Book GA, Gray KM. The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial. Drug Alcohol Depend. 2018;185:17–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ray LA, Bujarski S, Roche DJO, Magill M. Overcoming the “Valley of Death” in medications development for alcohol use disorder. Alcohol: Clin Exp Res. 2018;42:1612–22.

Article  PubMed  Google Scholar 

Seyhan AA. Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles. Transl Med Commun. 2019;4:1–19.

Article  Google Scholar 

Cohen-Gilbert JE, Jensen JE, Silveri MM. Contributions of magnetic resonance spectroscopy to understanding development: potential applications in the study of adolescent alcohol use and abuse. Dev Psychopathol. 2014;26:405–23.

Article  PubMed  PubMed Central  Google Scholar 

Kohut SJ, Kaufman MJ. Magnetic resonance spectroscopy studies of substance use disorders: current landscape and potential future directions. Pharmacol Biochem Behav. 2021;200:173090.

Article  CAS  PubMed  Google Scholar 

Kirkland AE, Browning BD, Green R, Leggio L, Meyerhoff DJ, Squeglia LM. Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies. Mol Psychiatry. 2022;27:3223–36.

Bustillo JR. Use of proton magnetic resonance spectroscopy in the treatment of psychiatric disorders: a critical update. Dialogues Clin Neurosci. 2022;15:329–37.

Schmaal L, Veltman DJ, Nederveen A, Van Den Brink W, Goudriaan AE. N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study. Neuropsychopharmacology/ 2012;37:2143–52.

Article  CAS  PubMed  Google Scholar 

Coles LD, Tuite PJ, Öz G, Mishra UR, Kartha RV, Sullivan KM, et al. Repeated‐dose oral N‐acetylcysteine in Parkinson’s disease: pharmacokinetics and effect on brain glutathione and oxidative stress. J Clin Pharmacol. 2018;58:158–67.

Article  CAS  PubMed  Google Scholar 

Tuura ROG, Warnock G, Ametamey S, Treyer V, Noeske R, Buck A, et al. Imaging glutamate redistribution after acute N-acetylcysteine administration: a simultaneous PET/MR study. NeuroImage. 2019;184:826–33.

Article