Recent advances of LSD1/KDM1A inhibitors for disease therapy

Keywords

Epigenetics

Histone demethylase

LSD1 inhibitors

Structure-activity relationships

TAK-418

AbbreviationsAIDS

acquired immune deficiency syndrome

AML

acute myeloid leukemia

APL

Acute promyelocytic leukemia

CNS

central nervous system

hERG

human ether-a-go-go-related gene

FAD

flavin adenine dinucleotide

GFI1

Growth factor independent 1 transcriptional repressor

GFI1B

Growth factor independent 1B transcriptional repressor

IGFBP3

insulin-like growth factor-binding protein 3

LSD2

Lysine-specific demethylase 2

MAPK

mitogen-activated protein kinase

MLL

mixed-lineage leukemia

mTOR

mammalian target of rapamycin

MYCN

v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

NMDA

N-methyl-d-aspartic acid

2-PCPA

2-phenylcycloproylamine

PI3K

phosphatidylinositol 3 kinase

TNF-α

Tumor necrosis factor-α

T-ALL

T-cell acute lymphoblastic leukemia

Data availability

The data that has been used is confidential.

© 2023 Elsevier Inc. All rights reserved.

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