Iannone M.a· Salvia G.a· Fidanzi C.a· Bevilacqua M.b· Janowska A.a· Morganti R.b· Romanelli M.a· Dini V.a

Author affiliations

aDepartment of Dermatology, University of Pisa, Pisa, Italy
bDepartment of Clinical and Experimental Medicine, Section of Statistics, University of Pisa, Pisa, Italy

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Article / Publication Details

First-Page Preview

Received: September 17, 2022
Accepted: December 05, 2022
Published online: February 20, 2023

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

Abstract

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites. Methods: Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses. Results: SAA levels were significantly associated with number of nodules (p = 0.005), abscesses (p < 0.001), fistulas (p = 0.016), and severe IHS4 (p = 0.088 and r = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4. Conclusions: We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease’s flare and potential complications.

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References Iannone M, Oranges T, Chiricozzi A, De Tata V, Romanelli M, Dini V. Potential role of serum amyloid A in hidradenitis suppurativa. JAAD Case Rep. 2019;5:406–9. Iannone M, Janowska A, Oranges T, Balderi L, Benincasa BB, Vitali S, et al. Ultrasound-guided injection of intralesional steroids in acute hidradenitis suppurativa lesions: a prospective study. Dermatol Ther. 2021;34(5):e15068. Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mosner R, Shomroni O, et al. The IL-1 pathway is hyperactive in hidradenitis suppurativa and contributes to skin infiltration and destruction. J Invest Dermatol. 2019;139(6):1294–305. Amur A. Biomarker terminology: speaking the same language. US Food and Drug Administration. https://www.fda.gov/files/BIOMARKER-TERMINOLOGY–SPEAKING-THE-SAME-LANGUAGE.pdf (accessed November 18, 2022). [Google Scholar]. Der Sarkissian S, Hessam S, Kirby JS, Lowes MA, Mintoff D, Naik HB, et al. Identification of biomarkers and critical evaluation of biomarker validation in hidradenitis suppurativa: a systematic review. JAMA Dermatol. 2022;158(3):300–13. Zouboulis CC, Del Marmol V, Mrowietz U, Prens EP, Tzellos T, Jemec GBE. Hidradenitis suppurativa/acne inversa: criteria for diagnosis, severity assessment, classification and disease evaluation. Dermatology. 2015;231(2):184–90. Akdogan N, Dogan S, Incel-Uysal P, Karabulut E, Topcuoglu C, Yalcin B, et al. Serum amyloid A and C-reactive protein levels and erythrocyte sedimentation rate are important indicators in hidradenitis suppurativa. Arch Dermatol Res. 2020;312(4):255–62. Yu N, Zhang S, Lu J, Li Y, Yi X, Tang L, et al. Serum amyloid A, an acute phase protein, stimulates proliferative and proinflammatory responses of keratinocytes. Cell Prolif. 2017;50(3):e12320. Article / Publication Details

First-Page Preview

Received: September 17, 2022
Accepted: December 05, 2022
Published online: February 20, 2023

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

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