Sex and Gender Differences in Parkinson's Disease

Cerri S. Mus L. Blandini F.

Parkinson’s disease in women and men: what’s the difference?.

J Parkinson’s Dis. 9: 501Clayton J.A. Tannenbaum C.

Reporting sex, gender, or both in clinical research?.

JAMA. 316: 1863-1864

Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson’s disease: a contribution to sex-specific neuroprotection by estrogens.

Horm Behav. 57: 23-34Kusters C.D.J. Paul K.C. Duarte Folle A. et al.

Increased menopausal age reduces the risk of parkinson’s disease: a mendelian randomization approach.

Mov Disord. 36: 2264-2272Yadav R. Shukla G. Goyal V. et al.

A case control study of women with Parkinson’s disease and their fertility characteristics.

J Neurol Sci. 319: 135-138Nicoletti A. Nicoletti G. Arabia G. et al.

Reproductive factors and Parkinson’s disease: a multicenter case-control study.

Mov Disord. 26: 2563-2566Liu R. Baird D. Park Y. et al.

Female reproductive factors, menopausal hormone use, and Parkinson’s disease.

Mov Disord. 29: 889-896Currie L.J. Harrison M.B. Trugman J.M. et al.

Postmenopausal estrogen use affects risk for Parkinson disease.

Arch Neurol. 61: 886-888Ragonese P. D’Amelio M. Callari G. et al.

Age at menopause predicts age at onset of Parkinson’s disease.

Mov Disord. 21: 2211-2214Canonico M. Pesce G. Bonaventure A. et al.

Increased risk of parkinson’s disease in women after bilateral oophorectomy.

Mov Disord. 36: 1696-1700Benedetti M.D. Maraganore D.M. Bower J.H. et al.

Hysterectomy, menopause, and estrogen use preceding Parkinson’s disease: an exploratory case-control study.

Mov Disord. 16: 830-837Avram C.M. Brumbach B.H. Hiller A.L.

A report of tamoxifen and parkinson’s disease in a US population and a review of the literature.

Mov Disord. 36: 1238-1242Maraganore D.M. Farrer M.J. McDonnell S.K. et al.

Case-control study of estrogen receptor gene polymorphisms in Parkinson’s disease.

Movement Disord. 17: 509-512Yoo J.E. Shin D.W. Jang W. et al.

Female reproductive factors and the risk of Parkinson’s disease: a nationwide cohort study.

Eur J Epidemiol. 35: 871-878Lv M. Zhang Y. Chen G.C. et al.

Reproductive factors and risk of Parkinson’s disease in women: a meta-analysis of observational studies.

Behav Brain Res. 335: 103-110Lundin J.I. Ton T.G.N. LaCroix A.Z. et al.

Formulations of hormone therapy and risk of Parkinson disease.

Mov Disord. 29: 1631-1636Song Y.J. ran Li S. wan Li X. et al.

The Effect of estrogen replacement therapy on alzheimer’s disease and parkinson’s disease in postmenopausal women: a meta-analysis.

Front Neurosci. 14: 157Park H.K. Ilango S. Charriez C.M. et al.

Lifetime exposure to estrogen and progressive supranuclear palsy: ENGENE-PSP study.

Mov Disord. 33: 468-472Lee Y.H. Cha J. Chung S.J. et al.

Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease.

Sci Rep. 9: 10531Fernandez H.H. Lapane K.L.

Estrogen use among nursing home residents with a diagnosis of Parkinson’s disease.

Mov Disord. 15: 1119-1124Parkinson Study Group POETRY Investigators

A randomized pilot trial of estrogen replacement therapy in post-menopausal women with Parkinson’s disease.

Parkinsonism Relat Disord. 17: 757-760Georgiev D. Hamberg K. Hariz M. et al.

Gender differences in Parkinson’s disease: a clinical perspective.

Acta Neurol Scand. 136: 570-584Pringsheim T. Jette N. Frolkis A. et al.

The prevalence of Parkinson’s disease: a systematic review and meta-analysis.

Mov Disord. 29: 1583-1590Brakedal B. Toker L. Haugarvoll K. et al.

A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population.

Npj Parkinsons Dis. 8: 1-8Moisan F. Kab S. Mohamed F. et al.

Parkinson disease male-to-female ratios increase with age: french nationwide study and meta-analysis.

J Neurol Neurosurg Psychiatr. 87: 952-957Gan-Or Z. Leblond C.S. Mallett V. et al.

LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis.

Parkinsonism Relat Disord. 21: 778-782Rui Q. Ni H. Li D. et al.

The role of LRRK2 in neurodegeneration of parkinson disease.

Curr Neuropharmacol. 16: 1348-1357Savica R. Grossardt B.R. Bower J.H. et al.

Risk factors for Parkinson’s disease may differ in men and women: An exploratory study.

Horm Behav. 63: 308-314Haaxma C.A. Bloem B.R. Borm G.F. et al.

Gender differences in Parkinson’s disease.

J Neurol Neurosurg Psychiatr. 78: 819-824Augustine E.F. Pérez A. Dhall R. et al.

Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease.

PLoS One. 10: e0133002Abraham D.S. Gruber-Baldini A.L. Magder L.S. et al.

Sex differences in Parkinson’s disease presentation and progression.

Parkinsonism Relat Disord. 69: 48-54Colombo D. Abbruzzese G. Antonini A. et al.

The “gender factor” in wearing-off among patients with Parkinson’s disease: a post hoc analysis of DEEP study.

ScientificWorldJournal. 2015: 787451Kim R. Lee J. Kim Y. et al.

Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson’s disease: an analysis of the PPMI cohort.

Parkinsonism Relat Disord. 51: 49-54Tosserams A. Mazaheri M. Vart P. et al.

Sex and freezing of gait in Parkinson’s disease: a systematic review and meta-analysis.

J Neurol. 268: 125-132Parashos S.A. Bloem B.R. Browner N.M. et al.

What predicts falls in Parkinson disease?.

Neurol Clin Pract. 8: 214-222Kuusimäki T. Kurki S. Sipilä J.O.T. et al.

Sex-dependent improvement in survival of parkinson’s disease patients.

Mov Disord Clin Pract. 7: 516-520Fullard M.E. Thibault D.P. Todaro V. et al.

Sex disparities in health and health care utilization after Parkinson diagnosis: rethinking PD associated disability.

Parkinsonism Relat Disord. 48: 45-50

Should exercise be prescribed differently between women and men? An emphasis on women diagnosed with parkinson’s disease.

Front Physiol. 9 () ()Zappia M. Annesi G. Nicoletti G. et al.

Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study.

Arch Neurol. 62: 601-605Conti V. Izzo V. Russillo M.C. et al.

Gender differences in levodopa pharmacokinetics in levodopa-naïve patients with parkinson’s disease.

Front Med. 9 () ()Bachmann C.G. Zapf A. Brunner E. et al.

Dopaminergic treatment is associated with decreased body weight in patients with Parkinson’s disease and dyskinesias.

Eur J Neurol. 16: 895-901Weintraub D. Claassen D.O.

Impulse control and related disorders in parkinson’s disease.

Int Rev Neurobiol. 133: 679-717Martinez-Martin P. Falup Pecurariu C. Odin P. et al.

Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease.

J Neurol. 259: 1639-1647Solla P. Masala C. Liscia A. et al.

Sex-related differences in olfactory function and evaluation of possible confounding factors among patients with Parkinson’s disease.

J Neurol. 267: 57-63Ou R. Lin J. Liu K. et al.

Evolution of apathy in early parkinson’s disease: a 4-years prospective cohort study.

Front Aging Neurosci. 12 () ()Lubomski M. Louise Rushworth R. Lee W. et al.

Sex differences in Parkinson’s disease.

J Clin Neurosci. 21: 1503-1506

Sex and gender in older adults’ experience of Parkinson’s disease.

J Gerontol B Psychol Sci Soc Sci. 63: S42-S48Gonzalez-Latapi P. Bayram E. Litvan I. et al.

Cognitive impairment in parkinson’s disease: epidemiology, clinical profile, protective and risk factors.

Behav Sci (Basel). 11: 74Oltra J. Segura B. Uribe C. et al.

Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder.

J Neurol. 269: 1591-1599Gao L. Nie K. Tang H. et al.

Sex differences in cognition among Chinese people with Parkinson’s disease.

J Clin Neurosci. 22: 488-492Liu R. Umbach D.M. Peddada S.D. et al.

Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease.

Neurology. 84: 2107-2115Curtis A.F. Masellis M. Camicioli R. et al.

Cognitive profile of non-demented Parkinson’s disease: Meta-analysis of domain and sex-specific deficits.

Parkinsonism Relat Disord. 60: 32-42Tremblay C. Abbasi N. Zeighami Y. et al.

Sex effects on brain structure in de novo Parkinson’s disease: a multimodal neuroimaging study.

Brain. 143: 3052-3066Saunders-Pullman R. Wang C. Stanley K. et al.

Diagnosis and Referral Delay in Women With Parkinson’s Disease.

Gend Med. 8: 209-217Urell C. Zetterberg L. Hellström K. et al.

Factors explaining physical activity level in Parkinson's disease: A gender focus.

Physiother Theor Pract. 37: 507-516Jost S.T. Strobel L. Rizos A. et al.

Gender gap in deep brain stimulation for Parkinson’s disease.

NPJ Parkinsons Dis. 8: 47Shpiner D.S. Di Luca D.G. Cajigas I. et al.

Gender Disparities in Deep Brain Stimulation for Parkinson’s Disease.

Neuromodulation. 22: 484-488

The decision-making process leading to deep brain stimulation in men and women with parkinson’s disease – an interview study.

BMC Neurol. 14: 89Nwabuobi L. Barbosa W. Sweeney M. et al.

Sex-related differences in homebound advanced Parkinson’s disease patients.

Clin Interv Aging. 14: 1371-1377Dahodwala N. Shah K. He Y. et al.

Sex disparities in access to caregiving in Parkinson disease.

Neurology. 90: e48-e54Tosserams A. Araújo R. Pringsheim T. et al.

Underrepresentation of women in Parkinson’s disease trials.

Movement Disord. 33: 1825-1826Subramanian I. Mathur S. Oosterbaan A. et al.

Unmet needs of women living with parkinson’s disease: gaps and controversies.

Movement Disord. 37: 444-455Dobkin R.D. Amondikar N. Kopil C. et al.

Innovative recruitment strategies to increase diversity of participation in parkinson’s disease research: the fox insight cohort experience.

J Parkinsons Dis. 10: 665-675Myers T.L. Augustine E.F. Baloga E. et al.

Recruitment for remote decentralized studies in parkinson’s disease.

J Parkinsons Dis. 12: 371-380Lin C.Y.R. Rosendale N. Deeb W.

Expanding sexual and gender minority research in movement disorders: More than awareness and acceptance.

Parkinsonism Relat Disord. 87: 162-165Rosendale N. Wong J.O. Flatt J.D. et al.

Sexual and gender minority health in neurology: a scoping review.

JAMA Neurol. 78: 747-754Baker K.E. Streed C.G. Durso L.E.

Ensuring That LGBTQI+ People Count - Collecting Data on Sexual Orientation, Gender Identity, and Intersex Status.

N Engl J Med. 384: 1184-1186Patel R.A. Stebbins G. Witek N.

Sexual orientation and gender identity documentation at an academic movement disorders neurology clinic.

Clin Park Relat Disord. 7: 100164

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