1 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2 Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3 Department of Infectious Diseases, Shanghai Ruijin Hospital, Shanghai 200025, China.

4 State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

5 Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases (20dz2261100), Shanghai 200025, China.

Keywords: metabolites, lactic acid bacteria, gut microbiota, immune system.

Abbreviations:

ADI – arginine deiminase pathway;

CNS – central nervous system;

CRC – colorectal cancer;

DC – dendritic cell;

ENS – enteric nervous system;

EPS – exopolysaccharide;

GABA – γ-aminobutyric acid;

GAD – glutamate decarboxylase system;

HePS – heteropolysaccharide;

HoPs – homopolysaccharide;

IEC – intestinal epithelial cell;

IL – interleukin;

LA – lactic acid;

LAB – lactic acid bacteria;

SCFA – short-chain fatty acid;

TJp – tight junction protein;

TLR – toll-like receptor.
Received originally: 18/10/2022 Received in revised form: 11/01/2023
Accepted: 17/02/2023 Published: 08/02/2023

Correspondence:
Yu-Feng Yao, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; yfyao@sjtu.edu.cn

Conflict of interest statement: The authors have declared no conflict of interest.
Please cite this article as: Huang Tang, Wanqiu Huang and Yu-Feng Yao (2023). The metabolites of lactic acid bacteria:classification, biosynthesis and modulation of gut microbiota. Microbial Cell 10(3): 49-62. doi: 10.15698/mic2023.03.792