Decitabine Versus Hydroxyurea for Advanced Proliferative Chronic Myelomonocytic Leukemia: Results of a Randomized Phase III Trial Within the EMSCO Network

Conception and design: Raphael Itzykson, Valeria Santini, Sylvain Thepot, Lionel Ades, Aristoteles Giagounidis, Ulrich Germing, Katharina Götze, Eric Solary, Sylvie Chevret, Uwe Platzbecker, Pierre Fenaux

Financial support: Sylvain Thepot

Administrative support: Sylvain Thepot, Rosa Sapena, Martin Puttrich, Silke Gloaguen, Sylvie Chevret, Uwe Platzbecker

Provision of study materials or patients: Raphael Itzykson, Sylvain Thepot, Lionel Ades, Aristoteles Giagounidis, Michael Lübbert, Stanislas Nimubona, Jose Miguel Torregrosa Diaz, Ulrich Germing, Sophie Park, Francesco Onida, Andrea Patriarca, Aspasia Stamatoullas, Katharina Götze, Uwe Platzbecker

Collection and assembly of data: Raphael Itzykson, Valeria Santini, Sylvain Thepot, Lionel Ades, Aristoteles Giagounidis, Margot Morabito, Michael Lübbert, Rosa Sapena, Stanislas Nimubona, Eric Wattel, Gina Zini, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, Robert Navarro, Katharina Götze, Martin Puttrich, Sandra Mossuto, Eric Solary, Silke Gloaguen, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux

Data analysis and interpretation: Raphael Itzykson, Valeria Santini, Sylvain Thepot, Lionel Ades, Cendrine Chaffaut, Aristoteles Giagounidis, Nathalie Droin, Jean Goasguen, Jose Miguel Torregrosa Diaz, Ulrich Germing, Andrea Patriarca, Aspasia Stamatoullas, Eric Solary, Sylvie Chevret, Uwe Platzbecker

Manuscript writing: All authors

Final approval of manuscript: All authors

Accountable for all aspects of the work: All authors

AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Decitabine Versus Hydroxyurea for Advanced Proliferative Chronic Myelomonocytic Leukemia: Results of a Randomized Phase III Trial Within the EMSCO Network

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Raphael Itzykson

Honoraria: AbbVie, Astellas Pharma, Celgene/Bristol Myers Squibb, Novartis, Servier

Consulting or Advisory Role: Amgen, Celgene/Bristol Myers Squibb, Daiichi Sankyo Europe GmbH, Novartis, Servier

Research Funding: Janssen (Inst), Novartis (Inst)

Valeria Santini

Honoraria: Celgene/Bristol Myers Squibb, Novartis

Consulting or Advisory Role: Celgene/Bristol Myers Squibb, Novartis, Menarini, Takeda, Gilead Sciences, AbbVie, Syros Pharmaceuticals, Servier

Research Funding: Celgene (Inst)

Travel, Accommodations, Expenses: Janssen-Cilag, Celgene

Sylvain Thepot

Honoraria: Astellas Pharma, Novartis, AbbVie, BMSi

Travel, Accommodations, Expenses: Amgen, AbbVie

Lionel Ades

Honoraria: Celgene, AbbVie, Jazz Pharmaceuticals, BerGenBio, Silence Therapeutics, Novartis

Research Funding: Celgene (Inst)

Aristoteles Giagounidis

Stock and Other Ownership Interests: Novartis, Roche

Honoraria: Amgen, Novartis, Bristol Myers Squibb/Celgene

Consulting or Advisory Role: Bristol Myers Squibb/Celgene

Michael Lübbert

Consulting or Advisory Role: Syros Pharmaceuticals, AbbVie

Research Funding: Johnson & Johnson (Inst)

Ulrich Germing

Honoraria: Celgene, Novartis, Jazz Pharmaceuticals

Consulting or Advisory Role: Celgene

Research Funding: Celgene (Inst), Novartis (Inst)

Anna Maria Pelizzari

Travel, Accommodations, Expenses: Janssen-Ortho

Sophie Park

Honoraria: Novartis/Ipsen, Bristol Myers Squibb/Celgene

Consulting or Advisory Role: Novartis, Pfizer, Bristol Myers Squibb/Celgene

Research Funding: Pfizer, Takeda

Travel, Accommodations, Expenses: Pfizer, Novartis

Nadja Jaekel

Honoraria: Novartis

Georgia Metzgeroth

Honoraria: Roche Pharma AG, Novartis, GlaxoSmithKline

Consulting or Advisory Role: GlaxoSmithKline

Francesco Onida

Travel, Accommodations, Expenses: Takeda, Kyowa Kirin International, Medac

Andrea Patriarca

Consulting or Advisory Role: Sanofi, SOBI

Speakers' Bureau: Novartis Italy, Incyte

Aspasia Stamatoullas

Consulting or Advisory Role: Pfizer, Janssen

Travel, Accommodations, Expenses: Pfizer

Katharina Götze

Honoraria: BMS

Consulting or Advisory Role: BMS, AbbVie, Servier/Pfizer

Research Funding: BMS

Eric Solary

Research Funding: Servier (Inst)

Travel, Accommodations, Expenses: Novartis

Uwe Platzbecker

Honoraria: Celgene/Jazz, AbbVie, Curis, Geron, Janssen

Consulting or Advisory Role: Celgene/Jazz, Novartis, BMS GmbH & Co. KG

Research Funding: Amgen (Inst), Janssen (Inst), Novartis (Inst), BerGenBio (Inst), Celgene (Inst), Chris (Inst)

Patents, Royalties, Other Intellectual Property: part of a patent for a TFR-2 antibody (Rauner et al Nature Metabolics 2019)

Travel, Accommodations, Expenses: Celgene

Pierre Fenaux

Honoraria: Celgene

Research Funding: Celgene (Inst)

No other potential conflicts of interest were reported.

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