Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial

Psychotherapy and Psychosomatics

Tsuchiyagaito A.a,b,c· Misaki M.Kirlic N.Yu X.Sánchez S.M.a· Cochran G.a· Stewart J.L.a,b· Smith R.a,b· Fitzgerald K.D.d· Rohan M.L.a· Paulus M.P.Guinjoan S.M.a,e

Author affiliations

aLaureate Institute for Brain Research, Tulsa, OK, USA
bOxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA
cResearch Center for Child Mental Development, Chiba University, Chiba, Japan
dDepartment of Psychiatry, Columbia University, New York, NY, USA
eDepartment of Psychiatry, Oklahoma University Health Sciences Center at Tulsa, Tulsa, OK, USA

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Article / Publication Details

First-Page Preview

Abstract of Innovations

Received: August 22, 2022
Accepted: November 10, 2022
Published online: January 11, 2023

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

Abstract

Introduction: Repetitive negative thinking (RNT) is a cognitive process focusing on self-relevant and negative experiences, leading to a poor prognosis of major depressive disorder (MDD). We previously identified that connectivity between the precuneus/posterior cingulate cortex (PCC) and right temporoparietal junction (rTPJ) was positively correlated with levels of RNT. Objective: In this double-blind, randomized, sham-controlled, proof-of-concept trial, we employed real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) to delineate the neural processes that may be causally linked to RNT and could potentially become treatment targets for MDD. Methods: MDD-affected individuals were assigned to either active (n = 20) or sham feedback group (n = 19). RNT was measured by the Ruminative Response Scale-brooding subscale (RRS-B) before and 1 week after the intervention. Results: Individuals in the active but not in the sham group showed a significant reduction in the RRS-B; however, a greater reduction in the PCC-rTPJ connectivity was unrelated to a greater reduction in the RRS-B. Exploratory analyses revealed that a greater reduction in the retrosplenial cortex (RSC)-rTPJ connectivity yielded a more pronounced reduction in the RRS-B in the active but not in the sham group. Conclusions: RtfMRI-nf was effective in reducing RNT. Considering the underlying mechanism of rtfMIR-nf, the RSC and rTPJ could be part of a network (i.e., default mode network) that might collectively affect the intensity of RNT. Understanding the relationship between the functional organization of targeted neural changes and clinical metrics, such as RNT, has the potential to guide the development of mechanism-based treatment of MDD.

© 2023 S. Karger AG, Basel

References Lopez AD, Murray CC. The global burden of disease, 1990–2020. Nat Med. 1998;4(11):1241–3. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34(1):13–25. Pincus HA, Pettit AR. The societal costs of chronic major depression. J Clin Psychiatry. 2001;62(Suppl 6):5–9. Cain RA. Navigating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study: practical outcomes and implications for depression treatment in primary care. Prim Care. 2007;34(3):505–19, vi, Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–17. Goldberg D The heterogeneity of “major depression”. World Psychiatry. 2011;10(3):226–8. Ehring T, Watkins ER. Repetitive negative thinking as a transdiagnostic process. Int J Cogn Ther. 2008;1(3):192–205. Bessette KL, Jacobs RH, Heleniak C, Peters AT, Welsh RC, Watkins ER, et al. Malleability of rumination: an exploratory model of CBT-based plasticity and long-term reduced risk for depressive relapse among youth from a pilot randomized clinical trial. PLoS One. 2020;15(6):e0233539. Watkins ER. Depressive rumination and co-morbidity: evidence for brooding as a transdiagnostic process. J Ration Emot Cogn Behav Ther. 2009;27(3):160–75. Watkins ER. Depressive rumination: investigating mechanisms to improve cognitive behavioural treatments. Cogn Behav Ther. 2009;38 Suppl 1(S1):8–14. Jones NP, Siegle GJ, Thase ME. Effects of rumination and initial severity on remission to cognitive therapy for depression. Cognit Ther Res. 2008;32(4):591–604. Schmaling KB, Dimidjian S, Katon W, Sullivan M. Response styles among patients with minor depression and dysthymia in primary care. J Abnorm Psychol. 2002;111(2):350–6. Cox RW, Jesmanowicz A, Hyde JS. Real-time functional magnetic resonance imaging. Magn Reson Med. 1995;33(2):230–6. deCharms RC. Applications of real-time fMRI. Nat Rev Neurosci. 2008;9(9):720–9. Tsuchiyagaito A, Misaki M, Zoubi OA;, Tulsa 1000 Investigators, Paulus M, Bodurka J. Prevent breaking bad: a proof of concept study of rebalancing the brain's rumination circuit with real-time fMRI functional connectivity neurofeedback. Hum Brain Mapp. 2021;42(4):922–40. Fede SJ, Dean SF, Manuweera T, Momenan R. A guide to literature informed decisions in the design of real time fMRI neurofeedback studies: a systematic review. Front Hum Neurosci. 2020;14:60. Misaki M, Tsuchiyagaito A, Al Zoubi O, Paulus M, Bodurka J; Tulsa 1000 Investigators 1000 Connectome-wide search for functional connectivity locus associated with pathological rumination as a target for real-time fMRI neurofeedback intervention. Neuroimage Clin. 2020;26:102244. Guidi J, Brakemeier EL, Bockting CLH, Cosci F, Cuijpers P, Jarrett RB, et al. Methodological recommendations for trials of psychological interventions. Psychother Psychosom. 2018;87(5):276–84. Nolen-Hoeksema S, Morrow J. A prospective study of depression and posttraumatic stress symptoms after a natural disaster: the 1989 Loma Prieta Earthquake. J Pers Soc Psychol. 1991;61(1):115–21. Treynor W, Gonzalez R, Nolen-Hoeksema S. Rumination reconsidered: a psychometric analysis. Cognit Ther Res. 2003;27:247–59. Kalish LA, Begg CB. Treatment allocation methods in clinical trials: a review. Stat Med. 1985;4(2):129–44. Suresh K. An overview of randomization techniques: an unbiased assessment of outcome in clinical research. J Hum Reprod Sci. 2011;4(1):8–11. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–9. Ros T, Enriquez-Geppert S, Zotev V, Young KD, Wood G, Whitfield-Gabrieli S, et al. Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain. 2020;143(6):1674–85. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33; quiz 34–57. Misaki M, Barzigar N, Zotev V, Phillips R, Cheng S, Bodurka J. Real-time fMRI processing with physiological noise correction: comparison with off-line analysis. J Neurosci Methods. 2015;256:117–21. Misaki M, Bodurka J. The impact of real-time fMRI denoising on online evaluation of brain activity and functional connectivity. J Neural Eng. 2021;18(4):046092. McLaren DG, Ries ML, Xu G, Johnson SC. A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches. Neuroimage. 2012;61(4):1277–86. Watson D, Clark LA. The PANAS-X: manual for the positive and negative affect schedule: expanded form. Iowa City, IA: The University of Iowa; 1994. Evans C, Margison F, Barkham M. The contribution of reliable and clinically significant change methods to evidence-based mental health. Evid Based Ment Health. 1998;1(3):70–2. Guhn M, Forer B, Zumbo BD. Reliable change index. In: Michalos AC, editor. Encyclopedia of quality of life and well-being research. Dordrecht: Springer; 2014. Jacobson NS, Truax P. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol. 1991;59(1):12–9. Fava GA, Guidi J, Rafanelli C, Rickels K. The clinical inadequacy of the placebo model and the development of an alternative conceptual framework. Psychother Psychosom. 2017;86(6):332–40. Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67(1):1–48. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B. 1995;57(1):289–300. Huber PJ. Robust regression: asymptotics, conjectures and Monte Carlo. Ann Statist. 1973;1(5):799–821. Venables WN, Ripley BD. Modern applied statistics with S. 4th ed. New York: Springer; 2002. Chen G, Saad ZS, Britton JC, Pine DS, Cox RW. Linear mixed-effects modeling approach to FMRI group analysis. Neuroimage. 2013;73:176–90. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006;129(Pt 3):564–83. Cauda F, Geminiani G, D’Agata F, Sacco K, Duca S, Bagshaw AP, et al. Functional connectivity of the posteromedial cortex. PLoS One. 2010;5(9):e13107. Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M. Direct reactivation of a coherent neocortical memory of context. Neuron. 2014;84(2):432–41. Wang G, Xie H, Wang L, Luo W, Wang Y, Jiang J, et al. Switching from fear to No fear by different neural ensembles in mouse retrosplenial cortex. Cereb Cortex. 2019;29(12):5085–97. Vann SD, Aggleton JP, Maguire EA. What does the retrosplenial cortex do? Nat Rev Neurosci. 2009;10(11):792–802. Fletcher PC, Frith CD, Grasby PM, Shallice T, Frackowiak RS, Dolan RJ. Brain systems for encoding and retrieval of auditory-verbal memory. An in vivo study in humans. Brain. 1995;118 ( Pt 2)(Pt 2):401–16. Bio BJ, Guterstam A, Pinsk M, Wilterson AI, Graziano MSA. Right temporoparietal junction encodes inferred visual knowledge of others. Neuropsychologia. 2022;171:108243. McEvoy PM, Mahoney AEJ, Moulds ML. Are worry, rumination, and post-event processing one and the same? Development of the repetitive thinking questionnaire. J Anxiety Disord. 2010;24(5):509–19. Nolen-Hoeksema S, Wisco BE, Lyubomirsky S. Rethinking rumination. Perspect Psychol Sci. 2008;3(5):400–24. Watkins E, Moulds M. Distinct modes of ruminative self-focus: impact of abstract versus concrete rumination on problem solving in depression. Emotion. 2005;5(3):319–28. Watkins ER, Nolen-Hoeksema S. A habit-goal framework of depressive rumination. J Abnorm Psychol. 2014;123(1):24–34. Lubianiker N, Paret C, Dayan P, Hendler T. Neurofeedback through the lens of reinforcement learning. Trends Neurosci. 2022;45(8):579–93. Thorslund J, McEvoy PM, Anderson RA. Group metacognitive therapy for adolescents with anxiety and depressive disorders: a pilot study. J Clin Psychol. 2020;76(4):625–45. Mehler DMA, Sokunbi MO, Habes I, Barawi K, Subramanian L, Range M, et al. Targeting the affective brain-a randomized controlled trial of real-time fMRI neurofeedback in patients with depression. Neuropsychopharmacology. 2018;43(13):2578–85. Rance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, et al. Time course of clinical change following neurofeedback. Neuroimage. 2018;181:807–13. Bruhl AB, Scherpiet S, Sulzer J, Stampfli P, Seifritz E, Herwig U. Real-time neurofeedback using functional MRI could improve down-regulation of amygdala activity during emotional stimulation: a proof-of-concept study. Brain Topogr. 2014;27(1):138–48. Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, et al. Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. J Vis Exp. 2012;59:3535. Sampaio-Baptista C, Neyedli HF, Sanders ZB, Diosi K, Havard D, Huang Y, et al. fMRI neurofeedback in the motor system elicits bidirectional changes in activity and in white matter structure in the adult human brain. Cell Rep. 2021;37(4):109890. Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, et al. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Transl Psychiatry. 2013;3(4):e250. Subramanian L, Hindle JV, Johnston S, Roberts MV, Husain M, Goebel R, et al. Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson’s disease. J Neurosci. 2011;31(45):16309–17. Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, et al. Randomized, sham-controlled trial of real-time functional magnetic resonance imaging neurofeedback for tics in adolescents with Tourette syndrome. Biol Psychiatry. 2020;87(12):1063–70. Takamura M, Okamoto Y, Shibasaki C, Yoshino A, Okada G, Ichikawa N, et al. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: a preliminary report. J Affect Disord. 2020;271:224–7. Zilverstand A, Sorger B, Sarkheil P, Goebel R. fMRI neurofeedback facilitates anxiety regulation in females with spider phobia. Front Behav Neurosci. 2015;9:148. Zweerings J, Sarkheil P, Keller M, Dyck M, Klasen M, Becker B, et al. Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder. Neuroimage Clin. 2020;28:102483. Kvamme TL, Ros T, Overgaard M. Can neurofeedback provide evidence of direct brain-behavior causality? Neuroimage. 2022;258:119400. Thibault RT, Lifshitz M, Birbaumer N, Raz A. Neurofeedback, self-regulation, and brain imaging: clinical science and fad in the service of mental disorders. Psychother Psychosom. 2015;84(4):193–207. Article / Publication Details

First-Page Preview

Abstract of Innovations

Received: August 22, 2022
Accepted: November 10, 2022
Published online: January 11, 2023

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

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