*Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China; and

†Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, China.

Correspondence: Xiaomin Chen, #59 Liuting St, Haishu District, Ningbo, 315010, Zhejiang, China (e-mail: [email protected]) or Weiping Du, #59 Liuting St, Haishu District, Ningbo, 315010, Zhejiang, China (e-mail: [email protected]).

Supported by Funding of the Plan of Science and Technology on Medical and Health in Zhejiang Province (No. 2021KY1002), Natural Science Foundation of Ningbo (No.2021J266), Ningbo province public welfare project (No. 20211JCGY020364), and the Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province (No. 2022E10026).

The authors report no conflicts of interest.

Z.X.Z. and C.J.S. designed experiments; Z.X.Z. and N.W. collected data; C.J.S., N.W., and J.W. analyzed experimental results. Z.X.Z. wrote the manuscript; W.P.D. and X.M.C. approved the manuscript. All authors read and approved the final manuscript.

Z. Zhang and C. Shen contributed equally to this work.

The analyzed datasets generated in the present study are available from the corresponding author upon reasonable request.

The institutional ethics committee of Ningbo First Hospital has approved this study.