Adamus A, Müller P, Nissen B et al (2018) GCSH antisense regulation determines breast cancer cells’ viability. Sci Rep 8(1):15399. https://doi.org/10.1038/s41598-018-33677-4 (PMID:30337557;PMCID:PMC6193953)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn SH, Yang HY, Tran GB et al (2015) Interaction of peroxiredoxin V with dihydrolipoamide branched chain transacylase E2 (DBT) in mouse kidney under hypoxia. Proteome Sci 13:4. https://doi.org/10.1186/s12953-014-0061-2 (PMID:25670924;PMCID:PMC4323032)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ajani JA, D’Amico TA, Almhanna K et al (2016) Gastric cancer, version 3.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 14(10):1286–1312. https://doi.org/10.6004/jnccn.2016.0137 (PMID: 27697982)

Article  PubMed  Google Scholar 

Ajani JA, D’Amico TA, Bentrem DJ et al (2022) Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 20(2):167–192. https://doi.org/10.6004/jnccn.2022.0008 (PMID: 35130500)

Article  CAS  PubMed  Google Scholar 

Ambrus A, Adam-Vizi V (2018) Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism. Neurochem Int 117:5–14. https://doi.org/10.1016/j.neuint.2017.05.018 (Epub 2017 Jun 2 PMID: 28579060)

Article  CAS  PubMed  Google Scholar 

Atakul T, Altinkaya SO, Abas BI et al (2020) Serum copper and zinc levels in patients with endometrial cancer. Biol Trace Elem Res 195(1):46–54. https://doi.org/10.1007/s12011-019-01844-x (Epub 2019 Aug 10 PMID: 31399869)

Article  CAS  PubMed  Google Scholar 

Barbie DA, Tamayo P, Boehm JS et al (2009) Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462(7269):108–112. https://doi.org/10.1038/nature08460 (Epub 2009 Oct 21. PMID: 19847166; PMCID: PMC2783335)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Z, Zhao JS, Li JJ et al (2010) A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics 9(12):2617–2628. https://doi.org/10.1074/mcp.M110.000661 (Epub 2010 Aug 10. PMID: 20699381; PMCID: PMC3101851)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charoentong P, Finotello F, Angelova M et al (2017) Pan-cancer Immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep 18(1):248–262. https://doi.org/10.1016/j.celrep.2016.12.019 (PMID: 28052254)

Article  CAS  PubMed  Google Scholar 

Chen DS, Mellman I (2013) Oncology meets immunology: the cancer-immunity cycle. Immunity 39(1):1–10. https://doi.org/10.1016/j.immuni.2013.07.012 (PMID: 23890059)

Article  CAS  PubMed  Google Scholar 

Chen DS, Mellman I (2017) Elements of cancer immunity and the cancer-immune set point. Nature 541(7637):321–330. https://doi.org/10.1038/nature21349 (PMID: 28102259)

Article  CAS  PubMed  Google Scholar 

Cheng C, Ding Q, Zhang Z et al (2020) PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1. J Cell Mol Med 24(9):5274–5289. https://doi.org/10.1111/jcmm.15183 (Epub 2020 Mar 24. PMID: 32207235; PMCID: PMC7205786)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conesa A, Madrigal P, Tarazona S et al (2016) A survey of best practices for RNA-seq data analysis. Genome Biol 17:13. https://doi.org/10.1186/s13059-016-0881-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denoyer D, Masaldan S, La Fontaine S et al (2015) Targeting copper in cancer therapy: ‘Copper That Cancer.’ Metallomics 7(11):1459–1476. https://doi.org/10.1039/c5mt00149h (Epub 2015 Aug 27 PMID: 26313539)

Article  CAS  PubMed  Google Scholar 

Denoyer D, Pearson HB, Clatworthy SA et al (2016) Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution. Oncotarget 7:37064–37080. https://doi.org/10.18632/oncotarget.9245 (PMID: 27175597; PMCID: PMC5095059)

Article  PubMed  PubMed Central  Google Scholar 

Fujita K, Motoyama S, Sato Y et al (2021) Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy. Med Oncol 38(1):6. https://doi.org/10.1007/s12032-020-01450-1 (PMID: 33411033)

Article  CAS  PubMed  Google Scholar 

Gajewski TF (2015) The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol 42(4):663–671. https://doi.org/10.1053/j.seminoncol.2015.05.011 (Epub 2015 Jun 3. PMID: 26320069; PMCID: PMC4555998)

Article  PubMed  PubMed Central  Google Scholar 

Gao W, Huang Z, Duan J et al (2021) Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A. Mol Oncol 15(12):3527–3544. https://doi.org/10.1002/1878-0261.13079 (Epub 2021 Sep 15. PMID: 34390123; PMCID: PMC8637554)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge EJ, Bush AI, Casini A et al (2022) Connecting copper and cancer: from transition metal signalling to metalloplasia. Nat Rev Cancer 22(2):102–113. https://doi.org/10.1038/s41568-021-00417-2 (Epub 2021 Nov 11. PMID: 34764459; PMCID: PMC8810673)

Article  CAS  PubMed  Google Scholar 

Goh WQ, Ow GS, Kuznetsov VA et al (2015) DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy. Am J Transl Res. 7(6):1140–1151 (PMID: 26279757; PMCID: PMC4532746)

PubMed  PubMed Central  Google Scholar 

Han J, Hu Y, Liu S et al (2022) A newly established cuproptosis-associated long non-coding RNA signature for predicting prognosis and indicating immune microenvironment features in soft tissue sarcoma. J Oncol 2022:8489387. https://doi.org/10.1155/2022/8489387 (PMID:35847354;PMCID:PMC9279026)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hänzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7. https://doi.org/10.1186/1471-2105-14-7 (PMID:23323831;PMCID:PMC3618321)

Article  PubMed  PubMed Central  Google Scholar 

Ji ZH, Ren WZ, Wang HQ et al (2022) Molecular subtyping based on cuproptosis-related genes and characterization of tumor microenvironment infiltration in kidney renal clear cell carcinoma. Front Oncol 12:919083. https://doi.org/10.3389/fonc.2022.919083 (PMID:35875087;PMCID:PMC9299088)

Article  PubMed  PubMed Central  Google Scholar 

Jochems C, Schlom J (2011) Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity. Exp Biol Med (maywood) 236(5):567–579. https://doi.org/10.1258/ebm.2011.011007 (PMID: 21486861; PMCID: PMC3229261)

Article  CAS  PubMed  Google Scholar 

Joyce JA, Fearon DT (2015) T cell exclusion, immune privilege, and the tumor microenvironment. Science 348(6230):74–80. https://doi.org/10.1126/science.aaa6204 (PMID: 25838376)

Article  CAS  PubMed  Google Scholar 

Kahlson MA, Dixon SJ (2022) Copper-induced cell death. Science 375(6586):1231–1232. https://doi.org/10.1126/science.abo3959 (Epub 2022 Mar 17 PMID: 35298241)

Article  CAS  PubMed  Google Scholar 

Kim BE, Nevitt T, Thiele DJ (2008) Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol 4(3):176–185. https://doi.org/10.1038/nchembio.72 (PMID: 18277979)

Article  CAS  PubMed  Google Scholar 

Kim ST, Cristescu R, Bass AJ et al (2018) Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat Med 24(9):1449–1458. https://doi.org/10.1038/s41591-018-0101-z (Epub 2018 Jul 16 PMID: 30013197)

Article  CAS  PubMed  Google Scholar 

Larkin J, Chiarion-Sileni V, Gonzalez R et al (2019) Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med 381(16):1535–1546. https://doi.org/10.1056/NEJMoa1910836 (Epub 2019 Sep 28 PMID: 31562797)

Article  CAS  PubMed  Google Scholar 

Lenartowicz M, Krzeptowski W (2010) Budowa i funkcja białek ATP7A i ATP7B–ATPaz transportujacych jony miedzi [Structure and function of ATP7A and ATP7B proteins–Cu-transporting ATPases]. Postepy Biochem 56(3):317–327 (PMID: 21117320)

PubMed  Google Scholar 

Liu Z, Yu M, Fei B et al (2018) miR-21-5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer. Oncol Rep 40(5):2955–2963. https://doi.org/10.3892/or.2018.6695 (Epub 2018 Sep 10 PMID: 30226598)

Article  CAS  PubMed  Google Scholar 

Lutsenko S (2010) Human copper homeostasis: a network of interconnected pathways. Curr Opin Chem Biol 14(2):211–217. https://doi.org/10.1016/j.cbpa.2010.01.003 (Epub 2010 Feb 1. PMID: 20117961; PMCID: PMC6365103)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv H, Liu X, Zeng X et al (2022) Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma. Front Pharmacol 13:930041. https://doi.org/10.3389/fphar.2022.930041 (PMID:35837286;PMCID:PMC9273972)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mariathasan S, Turley SJ, Nickles D et al (2018) TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554(7693):544–548. https://doi.org/10.1038/nature25501 (Epub 2018 Feb 14. PMID: 29443960; PMCID: PMC6028240)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menju T, Date H (2021) Lung cancer and epithelial-mesenchymal transition. Gen Thorac Cardiovasc Surg 69(5):781–789. https://doi.org/10.1