This work was supported by the Biotechnology and Biological Sciences Research Council, UK, project reference number 2241934, and the European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 862829, AVANT project. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.