Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119:1438–1449. https://doi.org/10.1172/JCI38019

Article  CAS  PubMed  PubMed Central  Google Scholar 

Best SA, Vandenberg CJ, Abad E, Whitehead L, Guiu L, Ding S, Brennan MS, Strasser A, Herold MJ, Sutherland KD, Janic A (2020) Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis. Cell Death Dis 11:877. https://doi.org/10.1038/s41419-020-03066-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biddle A, Gammon L, Liang X, Costea DE, Mackenzie IC (2016) Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma. EBioMedicine 4:138–145. https://doi.org/10.1016/j.ebiom.2016.01.007

Article  PubMed  PubMed Central  Google Scholar 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492

Article  PubMed  Google Scholar 

Bulsara VM, Worthington HV, Glenny AM, Clarkson JE, Conway DI, Macluskey M (2018) Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. Cochrane Database Syst Rev 12:CD006205. https://doi.org/10.1002/14651858.CD006205.pub4

Article  PubMed  Google Scholar 

Chen F, Cao Y, Huang J, Yan L, Lin L, Liu F, Liu F, Wu J, Qiu Y, Cai L, He B (2017) A novel prognostic index for oral squamous cell carcinoma patients with surgically treated. Oncotarget 8:55525–55533

Article  PubMed  PubMed Central  Google Scholar 

Chipuk JE, Maurer U, Green DR, Schuler M (2003) Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4:371–381. https://doi.org/10.1016/s1535-6108(03)00272-1

Article  CAS  PubMed  Google Scholar 

Feng J, Xu J, Xu Y, Xiong J, Xiao T, Jiang C, Li X, Wang Q, Li J, Li Y (2019) CLIC1 promotes the progression of oral squamous cell carcinoma via integrins/ERK pathways. Am J Transl Res 11:557–571

CAS  PubMed  PubMed Central  Google Scholar 

Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269:30761–30764

Article  CAS  PubMed  Google Scholar 

Hainaut P, Milner J (1993) A structural role for metal ions in the “wild-type” conformation of the tumor suppressor protein p53. Cancer Res 53:1739–1742

CAS  PubMed  Google Scholar 

Hou H, Sun D, Zhang X (2019) The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors. Cancer Cell Int 19:216. https://doi.org/10.1186/s12935-019-0937-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z, Zhou G, Li H, Rui X, Jin T, Li S, Zhang Y, Huang Z (2020) Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Am J Cancer Res 10:4287–4307

CAS  PubMed  PubMed Central  Google Scholar 

Kastenhuber ER, Lowe SW (2017) Putting p53 in context. Cell 170:1062–1078. https://doi.org/10.1016/j.cell.2017.08.028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274:948–953. https://doi.org/10.1126/science.274.5289.948

Article  CAS  PubMed  Google Scholar 

Liu X, Cao Y, Zhang Y, Zhou H, Li H (2019) Regulatory effect of MiR103 on proliferation, EMT and invasion of oral squamous carcinoma cell through SALL4. Eur Rev Med Pharmacol Sci 23:9931–9938

CAS  PubMed  Google Scholar 

Major AG, Pitty LP, Farah CS (2013) Cancer stem cell markers in head and neck squamous cell carcinoma. Stem Cells Int 2013:319489. https://doi.org/10.1155/2013/319489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37–43. https://doi.org/10.1038/376037a0

Article  CAS  PubMed  Google Scholar 

Ouyang Y, Jiang F, Zeng B, Wei C, Yu D (2017) miR-222 knockdown suppresses epithelial-to-mesenchymal transitionin human oral squamous cell carcinoma. Int J Clin Exp Pathol 10:11251–11259

PubMed  PubMed Central  Google Scholar 

Thomson PJ (2018) Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. J Oral Pathol Med 47:803–807. https://doi.org/10.1111/jop.12733

Article  CAS  PubMed  Google Scholar 

Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS (2015) Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Oncol Rep 34:1692–1700. https://doi.org/10.3892/or.2015.4177

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R, Lu X, Yu R (2020) lncRNA MALAT1 promotes EMT process and cisplatin resistance of oral squamous cell carcinoma via PI3K/AKT/m-TOR signal pathway. Onco Targets Ther 13:4049–4061. https://doi.org/10.2147/OTT.S251518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan L, Chen F, Liu F, Qiu Y, Wang J, Wu J, Bao X, Hu Z, Peng X, Lin X, Cai L, Lin L, He B (2017) Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure. Oncotarget 8:75094–75101

Article  PubMed  PubMed Central  Google Scholar 

Yao Y, Zhou WY, He RX (2019) Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-κB pathway. Biomed Pharmacother 109:1994–2004. https://doi.org/10.1016/j.biopha.2018.07.144

Article  CAS  PubMed  Google Scholar 

Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119:1429–1437. https://doi.org/10.1172/JCI36183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Yu H, Hu W (2014) The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (shanghai) 46:180–189. https://doi.org/10.1093/abbs/gmt147

Article  CAS  Google Scholar 

Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L (2014) Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma. Mol Cancer 13:133. https://doi.org/10.1186/1476-4598-13-133

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Regunath K, Jacq X, Prives C (2013) Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev 27:1739–1751. https://doi.org/10.1101/gad.212258.112

Article  CAS  PubMed  PubMed Central  Google Scholar