Bramwell VH, Morris D, Scott Ernst D, Hings I, Blackstein M, Venner PM, Ette EI, Harding MW, Waxman A, Demetri GD (2002) Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma. Clin Cancer Res 8:383–393
Cardoso F, van’t Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, et al 2016 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer. N Engl J Med 375 717–729.
Çolak Y, Nordestgaard BG, Afzal S (2020) Morbidity and mortality in carriers of the cystic fibrosis mutation CFTR Phe508del in the general population. Eur Respir J 56:2000558
de Oliveira J, Felipe AV, Neto RA, Oshima CT, de Souza SM, Forones NM (2014) Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer patients. Asian Pac J Cancer Prev 15:6935–6938
Del Vecchio CA, Feng Y, Sokol ES, Tillman EJ, Sanduja S, Reinhardt F, Gupta PB (2014) De-differentiation confers multidrug resistance via noncanonical perk-nrf2 signaling. PloS Biol 12:e1001945
PubMed PubMed Central Google Scholar
Dudez T, Borot F, Huang S, Kwak BR, Bacchetta M, Ollero M, Stanton BA, Chanson M (2008) CFTR in a lipid raft-TNFR1 complex modulates gap junctional intercellular communication and IL-8 secretion. Biochim Biophys Acta 1783(5):779–788
CAS PubMed PubMed Central Google Scholar
Eckford PD, Li C, Ramjeesingh M, Bear CE (2012) Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. J Biol Chem 287:36639–36649
CAS PubMed PubMed Central Google Scholar
Efferth T, Gillet JP, Sauerbrey A, Zintl F, Bertholet V, de Longueville F et al (2006) Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther 5:1986–1994
Fan L, Zhang Y, Zhou Y, Wang Z, Zhang Y, Chen H (2016) Clinical significance of ABC transporter expression in patients with hepatocellular carcinoma. J Hard Tissue Biol 25:81–88
Filipits M, Pohl G, Rudas M, Dietze O, Lax S, Grill R et al (2005) Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group. J Clin Oncol 23:1161–1168
Fletcher JI, Haber M, Henderson MJ, Norris MD (2010) ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 10:147–156
Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL et al (2012) Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150:1121–1134
CAS PubMed PubMed Central Google Scholar
Gu L, Wang Z, Zuo J, Li H, Zha L (2018) Prognostic significance of NF-κB expression in non-small cell lung cancer: a meta-analysis. PLoS ONE 13(5):e0198223
PubMed PubMed Central Google Scholar
Győrffy B (2021) Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J 19:4101–4109
PubMed PubMed Central Google Scholar
Győrffy B, Lánczky A, Szállási Z (2012) Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr-Relat Cancer 19:197–208
Győrffy B, Surowiak P, Budczies J, Lánczky A (2013) Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS ONE 8:e82241
PubMed PubMed Central Google Scholar
Hamai H, Keyserman F, Quittell LM, Worgall TS (2009) Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling. J Lipid Res 50:1101–1108
CAS PubMed PubMed Central Google Scholar
Jih K, Hwang T (2013) Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc Natl Acad Sci USA 110:4404–4409
CAS PubMed PubMed Central Google Scholar
Johnatty SE, Beesley J, Gao B, Chen X, Lu Y, Law MH et al (2013) ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the ovarian cancer association consortium and the cancer genome atlas. Gynecol Oncol 131:8–14
CAS PubMed PubMed Central Google Scholar
Kim J, Farahmand M, Dunn C, Milla CE, Horii RI, Thomas EA et al (2018) Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults. Sci Rep 1:16233
Li J, Zhang JT, Jiang X, Shi X, Shen J, Feng F et al (2015) The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer. Int J Oncol 46:2107–2115
Li H, Ma N, Wang J, Wang Y, Yuan C, Wu J et al (2018) Nicotine induces progressive properties of lung adenocarcinoma A549 cells by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) expression and plasma membrane localization. Technol Cancer Res Treat 17:1533033818809984
CAS PubMed PubMed Central Google Scholar
Liu J, Lichtenberg T, Poisson LM, Lazar AJ, Cherniack AD, Benz CC et al (2018) An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell 173:400–416
CAS PubMed PubMed Central Google Scholar
Ma M, Shi F, Zhai R, Wang H, Li K, Xu C, Yao W, Zhou F (2021) TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells. Mol Biol Rep 48(3):2365–2375
Marzac C, Garrido E, Tang R, Fava F, Hirsch P, Benedictis CD et al (2011) ATP binding cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients. Haematologica 96:1293–1301
CAS PubMed PubMed Central Google Scholar
Nagy A, Munkácsy G, Győrffy B (2021) Pancancer survival analysis of cancer hallmark genes. Sci Rep 11:6047
CAS PubMed PubMed Central Google Scholar
Noguchi K, Katayama K, Sugimoto Y (2014) Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics. Pharmacogenomics Pers Med 7:53–64
Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M et al (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817–2826
Pasello M, Giudice AM, Scotlandi K (2019) The ABC subfamily a transporters: multifaceted players with incipient potentialities in cancer. Semin Cancer Biol 60:57–71
Qian Y, Daza J, Itzel T, Betge J, Zhan T, Marmé F, Teufel A (2021) Prognostic cancer gene expression signatures: current status and challenges. Cells 10:648
PubMed PubMed Central Google Scholar
Reustle A, Fisel P, Renner O, Büttner F, Winter S, Rausch S et al (2018) Characterization of the breast cancer resistance protein (BCRP/ ABCG2) in clear cell renal cell carcinoma. Int J Cancer 143:3181–3193
Son JW, Kim YJ, Cho HM, Lee SY, Lee SM, Kang J et al (2011) Promoter hypermethylation of the CFTR gene and clinical/pathological features associated with non-small cell lung cancer. Respirology 16:1203–1209
Sone K, Oguri T, Uemura T, Takeuchi A, Fukuda S, Takakuwa O et al (2019) Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort. BMC Cancer 19:246
PubMed PubMed Central Google Scholar
Steinbach D, Gillet JP, Sauerbrey A, Gruhn B, Dawczynski K, Bertholet V et al (2006) ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia. Clin Cancer Res 12:4357–4363
Sun S, Cai J, Yang Q, Zhu Y, Zhao S, Wang Z (2016) Prognostic value and implication for chemotherapy treatment of ABCB1 in epithelial ovarian cancer: a meta-analysis. PLoS ONE 11:e0166058
PubMed PubMed Central Google Scholar
Theile D, Wizgall P (2021) Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection? Naunyn-Schmiedeberg’s Arch Pharmacol 394:1621–1632
van ’t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. 2002 van ’t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. 2002 Gene expression profiling predicts clinical outcome of breast cancer. Nature 415 530–536
Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T et al (2009) Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci USA 106:18825–18830
PubMed PubMed Central Google Scholar
Vander Borght S, Komuta M, Libbrecht L, Katoonizadeh A, Aerts R, Dymarkowski S et al (2008) Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin. Liver Int 28:1370–1380
Venet D, Dumont JE, Detours V (2011) Most random gene expression signatures are significantly associated with breast cancer outcome. PloS Comput Biol 7:e1002240
CAS PubMed PubMed Central Google Scholar
Vij N, Mazur S, Zeitlin PL (2009) CFTR is a negative regulator of NFkappaB mediated innate immune response. PLoS ONE 4(2):e4664
PubMed PubMed Central Google Scholar
Warta R, Theile D, Mogler C, Herpel E, Grabe N, Lahrmann B et al (2014) Association of drug transporter expression with mortality and progression-free survival in stage iv head and neck squamous cell carcinoma. PLoS ONE 9:e108908
PubMed PubMed Central Google Scholar
Weber AJ, Soong G, Bryan R, Saba S, Prince A (2001) Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl- channel function. Am J Physiol Lung Cell Mol Physiol 281(1):L71–L78
Xiao Q, Zhou Y, Lauschke VM (2020) Impact of variants in ATP-binding cassette transporters on breast cancer treatment. Pharmacogenomics 21:1299–1310
留言 (0)