The Role of Autophagy in Childhood Central Nervous System Tumors

Galluzzi L, et al. Autophagy-independent functions of the autophagy machinery. Cell. 2019;177(7):1682–99.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dikic I, et al. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018;19(6):349–64.

CAS  PubMed  Article  Google Scholar 

•• Mizushima N, et al. Autophagy in human diseases. N Engl J Med. 2020;383(16): 1564-76. This reference reviewed and discussed large preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as other common diseases.

Qiao CM, et al. Sodium butyrate causes alpha-synuclein degradation by an Atg5-dependent and PI3K/Akt/mTOR-related autophagy pathway. Exp Cell Res. 2020;387(1):111772.

CAS  PubMed  Article  Google Scholar 

Feng X, et al. Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. Autophagy. 2021;17(3):723–42.

CAS  PubMed  Article  Google Scholar 

Parzych KR, et al. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–73.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kim KH, et al. Autophagy--a key player in cellular and body metabolism. Nat Rev Endocrinol. 2014;10(6):322–37.

CAS  PubMed  Article  Google Scholar 

•• Onorati AV, et al. Targeting autophagy in cancer. Cancer 2018;124(16): 3307-18. This reference summarized fundamental advances in the biology of autophagy, approaches to targeting autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role of autophagy in tumor immunity, and recent developments in next-generation autophagy inhibitors that have clinical potential.

Menzies FM, et al. Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities. Neuron. 2017;93(5):1015–34.

CAS  PubMed  Article  Google Scholar 

Dong Y, et al. Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease. J Mol Cell Cardiol. 2019;136:27–41.

CAS  PubMed  Article  Google Scholar 

Jiang GM, et al. The relationship between autophagy and the immune system and its applications for tumor immunotherapy. Mol Cancer. 2019;18(1):17.

PubMed  PubMed Central  Article  Google Scholar 

Butera G, et al. Regulation of autophagy by nuclear GAPDH and its aggregates in cancer and neurodegenerative disorders. Int J Mol Sci. 2019;20(9):2062.

CAS  PubMed Central  Article  Google Scholar 

Rosenfeldt MT, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013;504(7479):296–300.

CAS  PubMed  Article  Google Scholar 

Yang A, et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov. 2014;4(8):905–13.

CAS  PubMed  PubMed Central  Article  Google Scholar 

White E. The role for autophagy in cancer. J Clin Invest. 2015;125(1):42–6.

PubMed  PubMed Central  Article  Google Scholar 

Joffre C, et al. [The yin and the yang of autophagy in cancer cells], Med Sci (Paris). 2017;33(3):328–34.

White E, et al. Autophagy, metabolism, and cancer. Clin Cancer Res. 2015;21(22):5037–46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Poillet-Perez L, et al. Role of tumor and host autophagy in cancer metabolism. Genes Dev. 2019;33(11-12):610–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Gao L, et al. Targeting ROS-mediated crosstalk between autophagy and apoptosis in cancer. Adv Exp Med Biol. 2020;1260:1–12.

CAS  PubMed  Article  Google Scholar 

Yun CW, et al. The roles of autophagy in cancer. Int J Mol Sci. 2018;19(11):3466.

PubMed Central  Article  Google Scholar 

Levy JMM, et al. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17(9):528–42.

CAS  PubMed  Article  Google Scholar 

• Udristioiu A, et al. Autophagy dysfunctions associated with cancer cells and their therapeutic implications. Biomed Pharmacother. 2019;115:108892 This reference reviewed recent insights of the molecular mechanism of autophagy and the potential roles of autophagy in cell death, cancer development, overview of the most recent therapeutic strategies involving autophagy modulators in cancer prevention and therapeutic opportunities.

CAS  PubMed  Article  Google Scholar 

Kimmelman AC, et al. Autophagy and tumor metabolism. Cell Metab. 2017;25(5):1037–43.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mowers EE, et al. Functions of autophagy in the tumor microenvironment and cancer metastasis. FEBS J. 2018;285(10):1751–66.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Camuzard O, et al. Autophagy in the crosstalk between tumor and microenvironment. Cancer Lett. 2020;490:143–53.

CAS  PubMed  Article  Google Scholar 

Wang Y, et al. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 2019;15(5):886–99.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bryant KL, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med. 2019;25(4):628–40.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen P, et al. Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death. J Exp Clin Cancer Res. 2019;38(1):254.

PubMed  PubMed Central  Article  Google Scholar 

Zhang P, et al. ATG7-dependent and independent autophagy determine the type of treatment in lung cancer. Pharmacol Res. 2021;163:105324.

CAS  PubMed  Article  Google Scholar 

Santanam U, et al. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016;30(4):399–407.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wang ZC, et al. MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5. Int J Biochem Cell Biol. 2019;111:63–71.

PubMed  Article  Google Scholar 

Wijshake T, et al. Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proc Natl Acad Sci U S A. 2021;118(5):e2020478118.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Gammoh N, et al. Suppression of autophagy impedes glioblastoma development and induces senescence. Autophagy. 2016;12(9):1431–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kuma A, et al. Autophagy-monitoring and autophagy-deficient mice. Autophagy. 2017;13(10):1619–28.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Amaravadi RK, et al. Targeting autophagy in cancer: recent advances and future directions. Cancer Discov. 2019;9(9):1167–81.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mittal V. Epithelial mesenchymal transition in tumor metastasis. Annu Rev Pathol. 2018;13:395–412.

CAS  PubMed  Article  Google Scholar 

Yeung KT, et al. Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol. 2017;11(1):28–39.

PubMed  Article  Google Scholar 

Gao T, et al. Long non-coding RNA 91H regulates IGF2 expression by interacting with IGF2BP2 and promotes tumorigenesis in colorectal cancer. Artif Cells Nanomed Biotechnol. 2020;48(1):664–71.

CAS  PubMed  Article  Google Scholar 

Pastushenko I, et al. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212–26.

CAS  PubMed  Article  Google Scholar 

Louis DN, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803–20.

PubMed  Article  Google Scholar 

Fruhwald MC, et al. Tumors of the central nervous system in children and adolescents. Dtsch Arztebl Int. 2011;108(22):390–7.

PubMed  PubMed Central 

留言 (0)

沒有登入
gif