Macrophages in intestinal fibrosis and regression

Keywords

Macrophages

Gastrointestinal tract

Inflammation

Fibrosis

Inflammatory bowel disease

AbbreviationsATX–LPA

autotaxin–lysophosphatidic acid

BMP2

bone morphogenetic protein 2

C1QA/C1QC

complement C1q A chain and C chain

CCL

C-C motif chemokine ligand

CCR

C-C motif chemokine receptor

COL1A1

collagen type 1 alpha 1 chain

CTSC/CTSD

cathepsin C and D

CX3CR

CX3C chemokine receptor

CXCL

C-X-C motif chemokine ligand

CXCR

C-X-C motif chemokine receptor

DSS

dextran sodium sulfate

ERK1/2

extracellular regulated protein kinase 1 and 2

Gr-1

granulocyte-differentiation antigen-1

Hes1

hairy and enhancer of split 1

HLA

human leukocyte antigen

Ly6C

lymphocyte antigen 6 complex

Mdm4

mouse double minute 4

MHCII

major histocompatibility complex II

Mrc1

mannose receptor C-type 1

Retnla

resistin-like molecule alpha

Runx3

runt-related transcription factor 3

SHIP

Src homology 2-containing inositol-5-phosphatase

SPP1

secreted phosphoprotein 1

STAT3

signal transducer and activator of transcription 3

Tim

the T cell, immunoglobulin, and mucin domain

TIMP-1

metallopeptidase inhibitor 1

TNBS

trinitrobenzene sulfonic acid

TREM

triggering receptor expressed on myeloid cells

α-SMA

α-smooth muscle actin

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