Akdis, M. et al. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J. Allergy Clin. Immunol. 127, 701–721.e1–e70 (2011).
CAS PubMed Article Google Scholar
Rider, P., Carmi, Y. & Cohen, I. Biologics for targeting inflammatory cytokines, clinical uses, and limitations. Int. J. Cell Biol. 2016, 9259646 (2016).
PubMed PubMed Central Article CAS Google Scholar
Donnelly, R. P., Young, H. A. & Rosenberg, A. S. An overview of cytokines and cytokine antagonists as therapeutic agents. Ann. N. Y. Acad. Sci. 1182, 1–13 (2009).
CAS PubMed PubMed Central Article Google Scholar
Pires, I. S., Hammond, P. T. & Irvine, D. J. Engineering strategies for immunomodulatory cytokine therapies — challenges and clinical progress. Adv. Ther. https://doi.org/10.1002/adtp.202100035 (2021).
Holder, P. G. et al. Engineering interferons and interleukins for cancer immunotherapy. Adv. Drug Deliv. Rev. 182, 114112 (2022).
CAS PubMed Article Google Scholar
Cunningham, B. C. et al. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254, 821–825 (1991).
CAS PubMed Article Google Scholar
Watowich, S. S., Hilton, D. J. & Lodish, H. F. Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol. Cell Biol. 14, 3535–3549 (1994).
CAS PubMed PubMed Central Google Scholar
Kossiakoff, A. A. & De Vos, A. M. Structural basis for cytokine hormone-receptor recognition and receptor activation. Adv. Protein Chem. 52, 67–108 (1998).
CAS PubMed Article Google Scholar
Brooks, A. J. et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science 344, 1249783 (2014).
PubMed Article CAS Google Scholar
Wilmes, S. et al. Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science 367, 643–652 (2020).
CAS PubMed PubMed Central Article Google Scholar
Glassman, C. R. et al. Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science 376, 163–169 (2022).
CAS PubMed Article Google Scholar
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K. & Silvennoinen, O. Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13, 369–398 (1995).
CAS PubMed Article Google Scholar
O’Shea, J. J. & Plenge, R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36, 542–550 (2012).
PubMed PubMed Central Article CAS Google Scholar
Levy, D. E. & Darnell, J. E. Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3, 651–662 (2002).
CAS PubMed Article Google Scholar
Morris, R., Kershaw, N. J. & Babon, J. J. The molecular details of cytokine signaling via the JAK/STAT pathway. Protein Sci. 27, 1984–2009 (2018).
CAS PubMed PubMed Central Article Google Scholar
Wells, J. A. & de Vos, A. M. Hematopoietic receptor complexes. Annu. Rev. Biochem. 65, 609–634 (1996).
CAS PubMed Article Google Scholar
Wang, X., Lupardus, P., Laporte, S. L. & Garcia, K. C. Structural biology of shared cytokine receptors. Annu. Rev. Immunol. 27, 29–60 (2009).
PubMed PubMed Central Article CAS Google Scholar
Rickert, M., Wang, X., Boulanger, M. J., Goriatcheva, N. & Garcia, K. C. The structure of interleukin-2 complexed with its α receptor. Science 308, 1477–1480 (2005).
CAS PubMed Article Google Scholar
Boulanger, M. J. & Garcia, K. C. Shared cytokine signaling receptors: structural insights from the gp130 system. Adv. Protein Chem. 68, 107–146 (2004).
CAS PubMed Article Google Scholar
van Boxel-Dezaire, A. H., Rani, M. R. & Stark, G. R. Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25, 361–372 (2006).
PubMed Article CAS Google Scholar
Donnelly, R. P. & Kotenko, S. V. Interferon-λ: a new addition to an old family. J. Interferon Cytokine Res. 30, 555–564 (2010).
CAS PubMed PubMed Central Article Google Scholar
Malek, T. R. The biology of interleukin-2. Annu. Rev. Immunol. 26, 453–479 (2008).
CAS PubMed Article Google Scholar
Lai, Y. & Dong, C. Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases. Int. Immunol. 28, 181–188 (2016).
CAS PubMed Article Google Scholar
Metcalf, D. Hematopoietic cytokines. Blood 111, 485–491 (2008).
CAS PubMed PubMed Central Article Google Scholar
Borden, E. C. et al. Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6, 975–990 (2007).
CAS PubMed PubMed Central Article Google Scholar
Gillis, S. & Smith, K. A. Long term culture of tumour-specific cytotoxic T cells. Nature 268, 154–156 (1977).
CAS PubMed Article Google Scholar
Morgan, D. A., Ruscetti, F. W. & Gallo, R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193, 1007–1008 (1976).
CAS PubMed Article Google Scholar
Rosenberg, S. A., Yang, J. C., White, D. E. & Steinberg, S. M. Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann. Surg. 228, 307–319 (1998).
CAS PubMed PubMed Central Article Google Scholar
McDermott, D. F. & Atkins, M. B. Application of IL-2 and other cytokines in renal cancer. Expert Opin. Biol. Ther. 4, 455–468 (2004).
CAS PubMed Article Google Scholar
Legha, S. S., Gianan, M. A., Plager, C., Eton, O. E. & Papadopoulous, N. E. Evaluation of interleukin-2 administered by continuous infusion in patients with metastatic melanoma. Cancer 77, 89–96 (1996).
CAS PubMed Article Google Scholar
Waldhauer, I. et al. Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy. MAbs 13, 1913791 (2021).
PubMed PubMed Central Article CAS Google Scholar
Ptacin, J. L. et al. An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat. Commun. 12, 4785 (2021).
CAS PubMed PubMed Central Article Google Scholar
Arellano, M. & Lonial, S. Clinical uses of GM-CSF, a critical appraisal and update. Biologics 2, 13–27 (2008).
CAS PubMed PubMed Central Google Scholar
Ng, T., Marx, G., Littlewood, T. & Macdougall, I. Recombinant erythropoietin in clinical practice. Postgrad. Med. J. 79, 367–376 (2003).
CAS PubMed PubMed Central Article Google Scholar
Tahtinen, S. et al. Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors. PLoS ONE 10, e0131242 (2015).
PubMed PubMed Central Article CAS Google Scholar
Liu, B. L. et al. ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther. 10, 292–303 (2003).
CAS PubMed Article Google Scholar
Andtbacka, R. H. I. et al. Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte–macrophage colony-stimulating factor in unresectable stage III–IV melanoma. J. Immunother. Cancer 7, 145 (2019).
PubMed PubMed Central Article Google Scholar
Pegram, H. J. et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 119, 4133–4141 (2012).
留言 (0)