Klein DC, Smoot R, Weller JL, Higa S, Markey SP, Creed GJ, et al. Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system. Brain Res Bull. 1983;10:647–52. https://doi.org/10.1016/0361-9230(83)90033-3

CAS  Article  PubMed  Google Scholar 

Perreau-Lenz S, Kalsbeek A, Garidou ML, Wortel J, Van Der Vliet J, Van Heijningen C, et al. Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms: Melatonin synthesis controlled by clock outputs. Eur J Neurosci. 2003;17:221–8. https://doi.org/10.1046/j.1460-9568.2003.02442.x

Article  PubMed  Google Scholar 

Lehman MN, Bittman EL, Newman SW. Role of the hypothalamic paraventricular nucleus in neuroendocrine responses to daylength in the golden hamster. Brain Res. 1984;308:25–32. https://doi.org/10.1016/0006-8993(84)90913-2

CAS  Article  PubMed  Google Scholar 

Kalsbeek A, Garidou ML, Palm IF, Van Der Vliet J, Simonneaux V, Pévet P, et al. Melatonin sees the light: blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin: GABA release in control of the daily melatonin rhythm. Eur J Neurosci. 2000;12:3146–54. https://doi.org/10.1046/j.1460-9568.2000.00202.x

CAS  Article  PubMed  Google Scholar 

Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577–84. https://doi.org/10.2147/VHRM.S24603

CAS  Article  PubMed  PubMed Central  Google Scholar 

Sun H, Gusdon AM, Qu S. Effects of melatonin on cardiovascular diseases: progress in the past year. Curr Opin Lipidol. 2016;27:408.

CAS  Article  Google Scholar 

Pandiperumal S, Trakht I, Srinivasan V, Spence D, Maestroni G, Zisapel N, et al. Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways. Prog Neurobiol. 2008;85:335–53. https://doi.org/10.1016/j.pneurobio.2008.04.001

CAS  Article  Google Scholar 

Laudon M, Grossman, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. VHRM. Published online September 2011: 577. https://doi.org/10.2147/VHRM.S24603

Akbari M, Ostadmohammadi V, Mirhosseini N, Lankarani KB, Tabrizi R, Keshtkaran Z, et al. The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens. 2019;33:202–9. https://doi.org/10.1038/s41371-019-0166-2

CAS  Article  PubMed  Google Scholar 

Bakris G, Ali W, Parati G. ACC/AHA Versus ESC/ESH on Hypertension Guidelines. J Am Coll Cardiol. 2019;73:3018–26. https://doi.org/10.1016/j.jacc.2019.03.507

Article  PubMed  Google Scholar 

Challet E. Minireview: Entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals. Endocrinology. 2007;148:5648–55. https://doi.org/10.1210/en.2007-0804

CAS  Article  PubMed  Google Scholar 

Holmes SW, Sugden D. Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat. Br J Pharm. 1976;56:360P–361P.

CAS  Google Scholar 

Zanoboni A, Forni A, Zanoboni-Muciaccia W, Zanussi C. Effect of pinealectomy on arterial blood pressure and food and water intake in the rat. J Endocrinol Invest. 1978;1:125–30. https://doi.org/10.1007/BF03350359

CAS  Article  PubMed  Google Scholar 

Kilic E, ÖUzdemir YG, Bolay H, Keleştimur H, Dalkara T. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cereb Blood Flow Metab. 1999;19:511–6. https://doi.org/10.1097/00004647-199905000-00005

CAS  Article  PubMed  Google Scholar 

Klimentova J, Cebova M, Barta A, Matuskova Z, Vrankova S, Rehakova R, et al. Effect of melatonin on blood pressure and nitric oxide generation in rats with metabolic syndrome. Physiol Res Published online Oct. 2016;29:S373–S380. https://doi.org/10.33549/physiolres.933436

Article  Google Scholar 

Nava M, Quiroz Y, Vaziri N, Rodríguez-Iturbe B. Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. Am J Physiol-Ren Physiol. 2003;284:F447–F454. https://doi.org/10.1152/ajprenal.00264.2002

CAS  Article  Google Scholar 

Pechánová O, Zicha J, Paulis L, Zenebe W, Dobesová Z, Kojsová S, et al. The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension. Eur J Pharmacol. 2007;561:129–36. https://doi.org/10.1016/j.ejphar.2007.01.035

CAS  Article  PubMed  Google Scholar 

Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P, et al. Lactacystin-induced model of hypertension in rats: effects of melatonin and captopril. IJMS. 2017;18:1612. https://doi.org/10.3390/ijms18081612

CAS  Article  PubMed Central  Google Scholar 

Mailliet F, Galloux P, Poisson D. Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats. Psychopharmacology. 2001;156:417–26. https://doi.org/10.1007/s002130100769

CAS  Article  PubMed  Google Scholar 

Paulis L, Pechanova O, Zicha J, Barta A, Gardlik R, Celec P, et al. Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension. J Pineal Res. 2010;48:102–8. https://doi.org/10.1111/j.1600-079X.2009.00732.x

CAS  Article  PubMed  Google Scholar 

Pliss MG, Kuzmenko NV, Rubanova NS, Tsyrlin VA. Dose-dependent mechanisms of melatonin on the functioning of the cardiovascular system and on the behavior of normotensive rats of different ages. Adv Gerontol. 2019;9:327–35. https://doi.org/10.1134/S2079057019030111

Article  Google Scholar 

Kennaway DJ, Voultsios A, Varcoe TJ, Moyer RW. Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism. Am J Physiol-Regul Integr Comp Physiol. 2002;282:R358–R365. https://doi.org/10.1152/ajpregu.00360.2001

CAS  Article  PubMed  Google Scholar 

Forman K, Vara E, García C, Kireev R, Cuesta S, Acuña-Castroviejo D, et al. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging: Melatonin effects on heart. J Pineal Res. 2010;49:312–20. https://doi.org/10.1111/j.1600-079X.2010.00800.x

CAS  Article  PubMed  Google Scholar 

Agabiti-Rosei C, De Ciuceis C, Rossini C, Porteri E, Rodella LF, Withers SB, et al. Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin. J Hypertension. 2014;32:1264–74. https://doi.org/10.1097/HJH.0000000000000178

CAS  Article  Google Scholar 

Favero G, Franco C, Stacchiotti A, Rodella LF, Rezzani R. Sirtuin1 role in the melatonin protective effects against obesity-related heart injury. Front Physiol. 2020;11:103. https://doi.org/10.3389/fphys.2020.00103

Article  PubMed  PubMed Central  Google Scholar 

Mutoh T, Shibata S, Korf HW, Okamura H. Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice. J Physiol. 2003;547:317–32. https://doi.org/10.1113/jphysiol.2002.028001

CAS  Article  PubMed  PubMed Central  Google Scholar 

Sun Y, Wang C, Zhang N, Liu F. Melatonin ameliorates hypertension in hypertensive pregnant mice and suppresses the hypertension-induced decrease in Ca2+-activated K+ channels in uterine arteries. Hypertens Res. 2021;44:1079–86. https://doi.org/10.1038/s41440-021-00675-5

CAS  Article  PubMed  Google Scholar 

Bertuglia S, Reiter RJ. Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J Pineal Res. 2009;46:307–13. https://doi.org/10.1111/j.1600-079X.2008.00662.x

CAS  Article  PubMed  Google Scholar 

Munley KM, Deyoe JE, Ren CC, Demas GE. Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters. Hormones Behav. 2020;117:104608. https://doi.org/10.1016/j.yhbeh.2019.104608

CAS  Article  Google Scholar 

Candia AA, Arias PV, González-Candia C, Navarrete A, Ebensperger G, Reyes RV, et al. Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function. Vasc Pharmacol. Published online February 2022: 106971. https://doi.org/10.1016/j.vph.2022.106971

Thakor AS, Allison BJ, Niu Y, Botting KJ, Serón‐Ferré M, Herrera EA, et al. Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. J Pineal Res. 2015;59:80–90. https://doi.org/10.1111/jpi.12242

CAS  Article  PubMed  PubMed Central  Google Scholar 

Molcan L. Telemetric data collection should be standard in modern experimental cardiovascular research. Physiol Behav. 2021;242:113620. https://doi.org/10.1016/j.physbeh.2021.113620

CAS  Article  PubMed  Google Scholar 

Van Vliet BN, Chafe LL, Antic V, Schnyder-Candrian S, Montani JP. Direct and indirect methods used to study arterial blood pressure. J Pharmacol Toxicol Methods. 2000;44:361–73. https://doi.org/10.1016/S1056-8719(00)00126-X

Article  PubMed  Google Scholar 

Quinn CM, Audet GN, Charkoudian N, Leon LR. Cardiovascular and thermoregulatory dysregulation over 24 h following acute heat stress in rats. Am J Physiol-Heart Circ Physiol. 2015;309:H557–H564. https://doi.org/10.1152/ajpheart.00918.2014

CAS  Article  PubMed  Google Scholar 

Molcan L, Sutovska H, Okuliarova M, Senko T, Krskova L, Zeman M. Dim light at night attenuates circadian rhythms in the cardiovascular system and suppresses melatonin in rats. Life Sci. 2019;231:116568. https://doi.org/10.1016/j.lfs.2019.116568

CAS  Article  PubMed  Google Scholar 

Witte K, Schnecko A, Buijs RM, van der Vliet J, Scalbert E, Delagrange P, et al. Effects of SCN lesions on circadian blood pressure rhythm in normotensive and transgenic hypertensive rats. Chronobiol Int. 1998;15:135–45. https://doi.org/10.3109/07420529808998678

CAS  Article  PubMed  Google Scholar 

Bazil MK, Krulan C, Webb RL. Telemetric monitoring of cardiovascular parameters in conscious spontaneously hypertensive rats. J Cardiovasc Pharm. 1993;22:897–905. https://doi.org/10.1097/00005344-199312000-00019

CAS  Article  Google Scholar 

Wilde E, Aubdool AA, Thakore P, Baldissera L Jr, Alawi KM, Keeble J, et al. Tail-cuff technique and its influence on central blood pressure in the mouse. J Am Heart Assoc. 2017;6:e005204.