Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424

Gruber-Rouh T, Naguib NN, Eichler K et al (2014) Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int J Cancer 134:1225–1231

CAS  Article  Google Scholar 

Van Cutsem E, Nordlinger B, Cervantes A (2010) Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. Ann Oncol 21(Suppl 5):v93–v97

Article  Google Scholar 

Adam R (2003) Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases. Ann Oncol 14(Suppl 2):ii13–ii16

Article  Google Scholar 

Maeda Y, Shinohara T, Nagatsu A, Futakawa N, Hamada T (2016) Long-term outcomes of conversion hepatectomy for initially unresectable colorectal liver metastases. Ann Surg Oncol 23(Suppl 2):S242–S248

Article  Google Scholar 

Folprecht G, Gruenberger T, Bechstein W et al (2014) Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann Oncol 25:1018–1025

CAS  Article  Google Scholar 

de Jong MC, Pulitano C, Ribero D et al (2009) Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 250:440–448

Mitry E, Fields AL, Bleiberg H et al (2008) Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials. J Clin Oncol 26:4906–4911

Nordlinger B, Sorbye H, Glimelius B et al (2013) Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol 14:1208–1215

Lorenz M, Müller HH, Schramm H et al (1998) Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. German Cooperative on Liver Metastases (Arbeitsgruppe Lebermetastasen). Ann Surg 228:756–762

Kemeny MM, Adak S, Gray B et al (2002) Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy--an intergroup study. J Clin Oncol 20:1499–1505

Fielding LP, Hittinger R, Grace RH, Fry JS (1992) Randomised controlled trial of adjuvant chemotherapy by portal-vein perfusion after curative resection for colorectal adenocarcinoma. Lancet 340:502–506

Liu Y, Chang W, Zhou B et al (2021) Conventional transarterial chemoembolization combined with systemic therapy versus systemic therapy alone as second-line treatment for unresectable colorectal liver metastases: randomized clinical trial. Br J Surg 108:373–379

Melchiorre F, Patella F, Pescatori L et al (2018) DEB-TACE: a standard review. Future Oncol 14:2969–2984

Huppert P, Wenzel T, Wietholtz H (2014) Transcatheter arterial chemoembolization (TACE) of colorectal cancer liver metastases by irinotecan-eluting microspheres in a salvage patient population. Cardiovasc Intervent Radiol 37:154–164

Article  Google Scholar 

Ngo A, von Stempel C, Corbo B et al (2019) Transarterial chemoembolisation of colorectal liver metastases with irinotecan-loaded beads: a bi-institutional analysis of 125 treatments in 53 patients. Cardiovasc Intervent Radiol 42:979–990

Lv Y, Feng QY, Wei Y et al (2020) Benefits of multi-disciplinary treatment strategy on survival of patients with colorectal cancer liver metastasis. Clin Transl Med 10:e121

Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216

Tang W, Ren L, Liu T et al (2020) Bevacizumab plus mFOLFOX6 versus mFOLFOX6 alone as first-line treatment for RAS mutant unresectable colorectal liver-limited metastases: the BECOME Randomized Controlled Trial. J Clin Oncol 38:3175–3184

Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309–318 discussion 318-21

CAS  Article  Google Scholar 

Weiser MR (2018) AJCC 8th Edition: Colorectal Cancer. Ann Surg Oncol 25:1454–1455

Article  Google Scholar 

Hamashige S, Arquilla ER (2008) Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Principles and Practice of Clinical Trial Medicine vol 42, pp 461–533

Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213

Article  Google Scholar 

Martin RC, Joshi J, Robbins K et al (2011) Hepatic intra-arterial injection of drug-eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi-institutional study. Ann Surg Oncol 18:192–198

Pernot S, Pellerin O, Artru P et al (2020) Intra-arterial hepatic beads loaded with irinotecan (DEBIRI) with mFOLFOX6 in unresectable liver metastases from colorectal cancer: a phase 2 study. Br J Cancer 123:518–524

Martin RC 2nd, Scoggins CR, Schreeder M et al (2015) Randomized controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver-limited metastasis. Cancer 121:3649–3658

Akinwande O, Dendy M, Ludwig JM, Kim HS (2017) Hepatic intra-arterial injection of irinotecan drug eluting beads (DEBIRI) for patients with unresectable colorectal liver metastases: a systematic review. Surg Oncol 26:268–275

Article  Google Scholar 

Zhao G, Liu S, Zhang Y et al (2021) Irinotecan eluting beads-transarterial chemoembolization using Callispheres® microspheres is an effective and safe approach in treating unresectable colorectal cancer liver metastases. Ir J Med Sci 191:1139–1145

Fiorentini G, Sarti D, Nani R, Aliberti C, Fiorentini C, Guadagni S (2020) Updates of colorectal cancer liver metastases therapy: review on DEBIRI. Hepat Oncol 7:Hep16

Ye L-C, Liu T-S, Ren L et al (2013) Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol 31:1931–1938

Liu M, Wang K, Wang Y et al (2021) Short- and long-term outcomes of hepatectomy combined with intraoperative radiofrequency ablation for patients with multiple primarily unresectable colorectal liver metastases: a propensity matching analysis. HPB (Oxford) 23:1586–1594

van Amerongen MJ, van der Stok EP, Fütterer JJ et al (2016) Short term and long term results of patients with colorectal liver metastases undergoing surgery with or without radiofrequency ablation. Eur J Surg Oncol 42:523–530

Conci S, Ruzzenente A, Pedrazzani C et al (2021) Simultaneous approach for patients with synchronous colon and rectal liver metastases: impact of site of primary on postoperative and oncological outcomes. Eur J Surg Oncol 47:842–849

Bogach J, Wang J, Griffiths C et al (2020) Simultaneous versus staged resection for synchronous colorectal liver metastases: a population-based cohort study. Int J Surg 74:68–75