Resveratrol inhibits TRAF6/PTCH/SMO signal and regulates prostate cancer progression

Aripaka K et al (2019) TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer. EBioMedicine 45:192–207

Article  Google Scholar 

Ashrafizadeh M et al (2021) Antitumor activity of resveratrol against gastric cancer: a review of recent advances with an emphasis on molecular pathways. Cancer Cell Int 21:66

CAS  Article  Google Scholar 

Cai K et al (2019) Targeting the crosstalk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma 60(3):772–781

CAS  Article  Google Scholar 

Chen Q et al (2020) Resveratrol attenuates neuroinflammation after deep hypothermia with circulatory arrest in rats. Brain Res Bull 155:145–154

CAS  Article  Google Scholar 

Cortes JE et al (2019) Hedgehog signaling inhibitors in solid and hematological cancers. Cancer Treat Rev 76:41–50

CAS  Article  Google Scholar 

Dias S et al (2013) Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. Prostate 73:1135–1146

CAS  Article  Google Scholar 

Ge Y et al (2019) Resveratrol protects BV2 mouse microglial cells against LPS-induced inflammatory injury by altering the miR-146a-5p/TRAF6/NF-κB axis. Immunopharmacol Immunotoxicol 41:549–557

CAS  Article  Google Scholar 

Gonnissen A et al (2017) Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer. BMC Cancer 17:634

Article  Google Scholar 

Guo Q et al (2020) By targeting TRAF6, miR-140-3p inhibits TGF-β1-induced human osteosarcoma epithelial-to-mesenchymal transition, migration, and invasion. Biotechnol Lett 42:2123–2133

CAS  Article  Google Scholar 

Hyuga T et al (2019) Hedgehog signaling for urogenital organogenesis and prostate cancer: an implication for the epithelial–mesenchyme interaction (EMI). Int J Mol Sci 21:58

Article  Google Scholar 

Kar S et al (2017) SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer. Biochim Biophys Acta 1863:253–265

CAS  Article  Google Scholar 

Khusbu F et al (2020) Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration. Int J Biochem Cell Biol 118:105644

CAS  Article  Google Scholar 

Krishna Moorthy H, Laxman Prabhu GG, Venugopal P (2019) The resurgence of estrogens in the treatment of castration-resistant prostate cancer. Indian J Urol 35:189–196

Article  Google Scholar 

Li G et al (2013) Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Cancer Prev Res (Phila) 6:27–39

CAS  Article  Google Scholar 

Li J et al (2014) A novel anticancer effect of resveratrol: reversal of epithelial–mesenchymal transition in prostate cancer cells. Mol Med Rep 10:1717–1724

CAS  Article  Google Scholar 

Li J et al (2014) A novel anti-cancer effect of resveratrol: reversal of epithelial–mesenchymal transition in prostate cancer cells. Mol Med Rep 10:1717–1724

CAS  Article  Google Scholar 

Massah S et al (2021) GLI activation by the estrogen receptor in breast cancer cells: regulation of cancer cell growth by Gli3. Mol Cell Endocrinol 522:111136

CAS  Article  Google Scholar 

Montano M et al (2018) Dual regulation of decorin by androgen and Hedgehog signaling during prostate morphogenesis. Dev Dyn 247:679–685

CAS  Article  Google Scholar 

Pak S et al (2019) The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway. J Exp Clin Cancer Res 38:342

Article  Google Scholar 

Pietrobono S, Gagliardi S, Stecca B (2019) Non-canonical Hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened. Front Genet 10:556

CAS  Article  Google Scholar 

Qu C et al (2018) Smoothened stabilizes and protects TRAF6 from degradation: a novel non-canonical role of smoothened with implications in lymphoma biology. Cancer Lett 436:149–158

CAS  Article  Google Scholar 

Sun W et al (2019) Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway. Oncol Rep 41:2689–2702

CAS  PubMed  PubMed Central  Google Scholar 

Tovar C et al (2011) MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer. Mol Cancer 10:49

CAS  Article  Google Scholar 

Uvez A et al (2020) Synergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivo. Pol J Vet Sci 23:571–580

CAS  PubMed  Google Scholar 

Yang R et al (2019) Polymeric micellar delivery of novel microtubule destabilizer and Hedgehog signaling inhibitor for treating chemoresistant prostate cancer. J Pharmacol Exp Ther 370:864–875

CAS  Article  Google Scholar 

Yang M et al (2020) TRAF6 promotes gastric cancer cell self-renewal, proliferation, and migration. Stem Cells Int 2020:3296192

PubMed  PubMed Central  Google Scholar 

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