*Pharmacology Laboratory, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China; and

†Department of Basic Nursing, School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China.

Correspondence: Lin-quan Zang, PhD, Department of Pharmacy, Pharmacology Laboratory, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China (e-mail: [email protected]).

Supported by the Young Innovative Talents Project of Guangdong Provincial Education Department (Fund No. 2020KQNCX036).

The authors have declared no conflicts of interest. Chen Jia-yao was mainly responsible for content selection and article writing. Wang Zhan-le and Li Ting ranked second and third respectively, working together with Chen Jia-yao. Wang Jiao-ling was mainly responsible for format correction and text proofreading. Zhang Yun supported the experiment by fund. Zang Linquan was in charge of experimental monitoring and guidance.

J.-y. Chen, T. Li, J.-l. Wang, and Z.-l. Wang contributed equally to this work and should be considered as co-first authors.

This study was approved by Ethics Review Meeting of Guangdong Pharmaceutical University Laboratory Animal Center [Animal License Number: SCXK (Guangdong) 2018-0002]. All animal handling in this experiment was performed in strict accordance with the Guide for the Care and Use of Laboratory Animals issued by the National Institutes of Health.