Research on kidney diseases is being transformed by the rapid expansion and innovations in omics technologies. Analysis, integration, and interpretation of big data, however, has been an impediment to the growing interest in applying these technologies to understand kidney function and failure. Targeting this urgent need, the University of Michigan O'Brien Kidney Translational Core Center (MKTC) and its Administrative Core established the Applied System Biology Core. The Core provides need-based support for the global kidney community centered on enabling incorporation of systems biology approaches by creating web-based, user-friendly analytical and visualization tools, like Nephroseq and Nephrocell, guiding with experimental design, and processing, analysis and integration of large data sets. The enrichment core supports systems biology education and dissemination through workshops, seminars, and individualized training sessions. Meanwhile, the Pilot and Feasibility Program of the MKTC provides pilot funding to both early-career and established investigators new to the field, to integrate a system biology approach into their research projects. The relevance and value of the portfolio of training and services offered by MKTC are reflected in the expanding community of young investigators, collaborators and users accessing resources and engaging in systems biology-based kidney research. Thereby motivating MKTC to persevere in its mission to serve the kidney research community through enabling access to state-of-the-art datasets, tools, technologies, expertise and learning opportunities for transformative basic, translational, and clinical studies that will usher in solutions to improve the lives of people impacted by kidney disease.