Persisting prediabetic conditions and glomerular filtration rate – A longitudinal study

Baseline eGFR (ml/min/1.73 m2) for persisting states was: NGT = 85.6, IFG = 85.3, IGT = 80.2, and T2DM = 87.2. During the follow-up a decrease in eGFR was observed in the total study population (mean = 6.1 ml/min/1.73 m2, SD = 11.9, 0.6 ml/min/1.73 m2/year). At baseline 2.1% (n = 28) of all participants (n = 1327) had CKD, and this increased to 8.3% at follow-up (n = 109). The decrease in eGFR was greater in individuals with persisting IGT when compared to those with persisting IFG; Δ eGFR (IGT-IFG) = 8.5 ml/min/1.73 m2, p = 0.004, CI 95%: 2.8–14.2, adjusted for confounders including baseline eGFR. There was no significant difference in the change in eGFR between individuals with persisting T2DM and individuals with persisting IGT, regardless of adjustments for age, sex, BMI or eGFR at baseline, Δ eGFR = 0.8 ml/min/1.73 m2, p = 0.731, CI 95%: −5.3 to 3.7. Additional adjustments for CRP didn't make any statistical difference. For baseline characteristics, se previous papers [Andersson S. Ekman I. Friberg F. Daka B. Lindblad U. Larsson C.A. The association between self-rated health and impaired glucose tolerance in Swedish adults: a cross-sectional study.].

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